Spatial distribution of venous gas emboli in the lungs

Journal of Applied Physiology

Volumn 87, Issue 5, 1999, Pages 1937-1947

  Souders, Jennifer E ^a   Doshier, Jeffrey B ^a   Polissar, Nayak L ^b   Hlastala, Michael P ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Mountain Whisper Light Statistical Consulting   (United States)

Author keywords

Air embolism; Decompression illness; Fluorescent microspheres; Pulmonary circulation; Pulmonary gas exchange

Indexed keywords

MICROSPHERE; NITROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GAS EMBOLISM; HEMODYNAMICS; LUNG BLOOD FLOW; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG GAS EXCHANGE; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032723525     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.5.1937     Document Type: Article

References (51)

1. Albertine, K. H., J. P. Wiener-Kronish, K. Koike, and N. C. Staub. Quantification of damage by air emboli to lung microvessels in anesthetized sheep. J. Appl. Physiol. 57: 1360-1368, 1984.
2. Atkins, C. E., C. E. Lehner, K. A. Beck, R. R. Dubielzig, E. V. Nordheim, and E. H. Lanphier. Experimental respiratory decompression sickness in sheep. J. Appl. Physiol. 65: 1163-1171, 1988.
3. Bassingthwaighte, J. B., M. A. Malone, T. C. Moffett, R. B. King, S. E. Little, J. M. Link, and K. A. Krohn. Validity of microsphere deposition for regional myocardial flows. Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H184-H193, 1987.
4. Bernard, S. L., R. W. Glenny, H. H. Erickson, M. R. Fedde, N. L. Polissar, R. J. Basaraba, and M. P. Hlastala. Minimal redistribution of pulmonary blood flow with exercise in race-horses. J. Appl. Physiol. 81: 1062-1070, 1996.
5. Butler, B. D., J. Conkin, and S. Luehr. Pulmonary hemodynamics, extravascular lung water and residual gas bubbles following low dose venous gas embolism in dogs. Aviat. Space Environ. Med. 60: 1178-1182, 1989.
6. Butler, B. D., and B. A. Hills. The lung as a filter for microbubbles. J. Appl. Physiol. 47: 537-543, 1979.
7. Butler, B. D., and B. A. Hills. Transpulmonary passage of venous air emboli. J. Appl. Physiol. 59: 543-547, 1985.
8. Butler, B. D., B. C. Leiman, and J. Katz. Arterial air embolism of venous origin in dogs: effect of nitrous oxide in combination with halothane and pentobarbitone. Can. J. Anaesth. 34: 570-575, 1987.
9. Butler, B. D., R. Robinson, T. Little, J. E. Chelly, and M. F. Doursout. Cardiopulmonary changes with moderate decompression in rats. Undersea Hyperb. Med. 23: 83-89, 1996.
10. Chang, H. K., L. Delaunois, R. Boileau, and R. R. Martin. Redistribution of pulmonary blood flow during experimental air embolism. J. Appl. Physiol. 51: 211-217, 1981.
11. Chang, H. K., M. E. Weber, J. Thomson, and R. R. Martin. Hydrodynamic features of pulmonary air embolism: a model study. J. Appl. Physiol. 51: 1002-1008, 1981.
12. Cockett, A. T., S. M. Pauley, D. N. Zehl, A. A. Pilmanis, and W. S. Cockett. Pathophysiology of bends and decompression sickness. An overview with emphasis on treatment. Arch. Surg. 114: 296-301, 1979.
13. Deal, C. W., P. Barton, F. Fielden, and I. Monk. Hemodynamic effects of pulmonary air embolism. J. Surg. Res. 11: 533-538, 1971.
14. Flick, M. R., J. M. Hoeffel, and N. C. Staub. Superoxide dismutase with heparin prevents increased lung vascular permeability during air emboli in sheep. J. Appl. Physiol. 55: 1284-1291, 1983.
15. Gan, R. Z., and R. T. Yen. Vascular impedance analysis in dog lung with detailed morphometric and elasticity data. J. Appl. Physiol. 77: 706-717, 1994.
16. Glenny, R. W., S. Bernard, and M. Brinkley. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J. Appl. Physiol. 74: 2585-2597, 1993.
17. Glenny, R. W., W. J. E. Lamm, R. K. Albert, and H. T. Robertson. Gravity is a minor determinant of pulmonary blood flow distribution. J. Appl. Physiol. 71: 620-629, 1991.
18. Glenny, R. W., N. L. Polissar, S. McKinney, and H. T. Robertson. Temporal heterogeneity of regional pulmonary perfusion is spatially clustered. J. Appl. Physiol. 79: 986-1001, 1995.
19. Hakim, T. S., G. W. Dean, and R. Lisbona. Effect of body posture on spatial distribution of pulmonary blood flow. J. Appl. Physiol. 64: 1160-1170, 1988.
20. Hakim, T. S., G. W. Dean, and R. Lisbona. Quantification of spatial blood flow distribution in isolated canine lung. Invest. Radiol. 23: 498-504, 1988.
21. Hakim, T. S., R. Lisbona, and G. W. Dean. Gravity-independent inequality in pulmonary blood flow in humans. J. Appl. Physiol. 63: 1114-1121, 1987.
22. Hakim, T. S., R. Lisbona, and G. W. Dean. Effect of cardiac output on gravity-dependent and nondependent inequality in pulmonary blood flow. J. Appl. Physiol. 66: 1570-1578, 1989.
23. Hales, J. R. S., and W. J. Cliff. Direct observations of the behaviour of microspheres in microvasculature. Bibl. Anat. 15: 87-91, 1977.
24. Heyman, M. A., B. D. Payne, J. I. Hoffman, and A. M. Rudolf. Blood flow measurement with radionuclide-labeled particles. Prog. Cardiovasc. Dis. 20: 55-79, 1977.
25. Hlastala, M. P., S. L. Bernard, H. H. Erickson, M. R. Fedde, E. M. Gaughan, R. McMurphy, M. J. Emery, N. L. Polissar, and R. W. Glenny. Pulmonary blood flow distribution in standing horses is not dominated by gravity. J. Appl. Physiol. 81: 1051-1061, 1996.
26. Hlastala, M. P., M. A. Chornuk, D. A. Self, H. J. Kallas, J. W. Burns, S. Bernard, N. L. Polissar, and R. W. Glenny. Pulmonary blood flow redistribution by increased gravitational force. J. Appl. Physiol. 84: 1278-1288, 1998.
27. Hlastala, M. P., H. T. Robertson, and B. K. Ross. Gas exchange abnormalities produced by venous gas emboli. Respir. Physiol. 36: 1-17, 1979.
28. Huang, K. L., and Y. C. Lin. Activation of complement and neutrophils increases vascular permeability during air embolism. Aviat. Space Environ. Med. 68: 300-305, 1997.
29. James, P. B. Dysbarism: the medical problems from high and low atmospheric pressure. J. R. Coll. Physicians Lond. 27: 367-374, 1993.
30. Jarvis, K. A., E. P. Steffey, W. S. Tyler, N. Willits, and M. Woliner. Pulmonary blood flow distribution in anesthetized ponies. J. Appl. Physiol. 72: 1173-1178, 1992.
31. Krenz, G. S., J. H. Linehan, and C. A. Dawson. A fractal continuum model of the pulmonary arterial tree. J. Appl. Physiol. 72: 2225-2237, 1992.
32. Loewenherz, J. W. Pathophysiology and treatment of decompression sickness and gas embolism. J. Fla. Med. Assoc. 79: 620-624, 1992.
33. Mure, M., K. B. Domino, H. T. Robertson, M. P. Hlastala, and R. W. Glenny. Pulmonary blood flow does not redistribute in dogs with reposition from supine to left lateral position. Anesthesiology 89: 483-492, 1998.
34. Ohkuda, K., K. Nakahara, A. Binder, and N. C. Staub. Venous air emboli in sheep: reversible increase in lung microvascular permeability. J. Appl. Physiol. 51: 887-894, 1981.
35. Oyama, Y., and M. P. Spencer. Cardiopulmonary effects of intravenous gas embolism; with special reference to fate of intravascular gas bubbles. Jpn. Circ. J. 35: 1541-1549, 1971.
36. Pilmanis, A. A. (Editor). Proceedings of the 1990 Hypobaric Decompression Sickness Workshop. Brooks AFB, TX: US Air Force Armstrong Laboratory, 1992. (Publ. AL-SR-1992-0005)
37. Presson, R. G., Jr., K. R. Kirk, K. A. Haselby, J. H. Linehan, S. Zaleski and W. W. Wagner, Jr. Fate of air emboli in the pulmonary circulation. J. Appl. Physiol. 67: 1898-1902, 1989.
38. Presson, R. G., Jr., K. R. Kirk, K. A. Haselby, and W. W. Wagner, Jr. Effect of ventilation with soluble and diffusible gases on the size of air emboli. J. Appl. Physiol. 70: 1068-1074, 1991.
39. Sergysels, R., N. Jasper, L. Delaunois, H. K. Chang, and R. R. Martin. Effect of ventilation with different gas mixtures on experimental lung air embolism. Respir. Physiol. 34: 329-343, 1978.
40. Shirai, M., K. Sada, and I. Ninomiya. Diameter and flow velocity changes in small pulmonary vessels due to microembolization. J. Appl. Physiol. 65: 288-296, 1988.
41. Steffey, E. P., B. H. Johnson, and E. I. D. Eger. Nitrous oxide intensifies the pulmonary arterial pressure response to venous injection of carbon dioxide in the dog. Anesthesiology 52: 52-55, 1980.
42. Van-Liew, H. D., and M. E. Burkard. Bubbles in circulating blood: stabilization and simulations of cyclic changes of size and content. J. Appl. Physiol. 79: 1379-1385, 1995.
43. Vann, R. D., and E. D. Thalmann. Decompression physiology and practice. In: The Physiology and Medicine of Diving (4th ed.), edited by P. B. Bennett and D. H. Elliott. London: Saunders, 1993, p. 376-432.
44. Verstappen, F. T., J. A. Bernards, and A. F. Kreuzer. Effects of pulmonary gas embolism on circulation and respiration in the dog. II. Effects on respiration. Pflügers Arch. 368: 599-604, 1977.
45. Verstappen, F. T., J. A. Bernards, and F. Kreuzer. Effects of pulmonary gas embolism on circulation and respiration in the dog. III. Excretion of venous gas bubbles by the lung. Pflügers Arch. 370: 67-70, 1977.
46. Vik, A., A. O. Brubakk, T. R. Hennessy, B. M. Jenssen, M. Ekker, and S. A. Slordahl. Venous air embolism in swine: transport of gas bubbles through the pulmonary circulation. J. Appl. Physiol. 69: 237-244, 1990.
47. 2 prebreathing on altitude decompression sickness and venous gas bubbles. Aviat. Space Environ. Med. 58, Suppl.: A110-A112, 1987.
48. Walmrath, D., R. Konig, C. Ernst, H. Bruckner, F. Grimminger, and W. Seeger. Ventilation-perfusion relationships in isolated blood-free perfused rabbit lungs. J. Appl. Physiol. 72: 374-382, 1992.
49. Walther, S. M., K. B. Domino, R. W. Glenny, and M. P. Hlastala. Pulmonary blood flow distribution in sheep: effects of anesthesia, mechanical ventilation, and change in posture. Anesthesiology 87: 335-342, 1997.
50. Walther, S. M., K. B. Domino, R. W. Glenny, N. L. Polissar, and M. P. Hlastala. Pulmonary blood flow distribution has a hilar-to-peripheral gradient in awake, prone sheep. J. Appl. Physiol. 82: 678-685, 1997.
51. Yen, R. T., and Y. C. Fung. Effect of velocity distribution on red cell distribution in capillary blood vessels. Am. J. Physiol. 235 (Heart Circ. Physiol. 4): H251-H257, 1978.