1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels

European Journal of Pharmacology

Volumn 379, Issue 2-3, 1999, Pages 151-159

  Adeagbo, Ayotunde S O ^a  

^a Biophys Ctr Appl M   (United States)

Author keywords

1 Ethyl benzimidazolinone; K(Ca) channel opener; Mesenteric vessel

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); APAMIN; ATROPINE; CHARYBDOTOXIN; CHLORPHENIRAMINE; CIRAZOLINE; CROMAKALIM; DENDROTOXIN; DIAZOXIDE; GLIBENCLAMIDE; GUANYLATE CYCLASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; OUABAIN; PENITREM A; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; PROPRANOLOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ION CURRENT; MALE; MESENTERY BLOOD FLOW; MESENTERY BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BENZIMIDAZOLES; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; VASODILATION; VASODILATOR AGENTS;

EID: 0032722382     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00489-6     Document Type: Article

References (30)

1. Ca channels and NO formation. The Endothelium: Gateway to New Therapeutics, Abstr. no. P1, p. 23.
2. Bonnet P., Michel A., Laurent F., Sablayrolles C., Rechenq E., Mani J.C., Boucard M., Chapat J.P. Synthesis and antibronchospatic activity of 8-alkoxy- and 8-alkylaminoimidazo[1,2-a]pyrazines. J. Med. Chem. 35:1992;3353-3358.
3. Boulton C.L., Southam E., Garthwaite J. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience. 69:1995;699-703.
4. + channel. Am. J. Physiol. 271:1996;L775-L784. Lung Cell. Mol. Physiol. 15.
5. K. Am. J. Physiol. 271:1996;L785-L795. Lung Cell. Mol. Physiol. 15.
6. Edwards G., Weston A.H. Potassium channel openers and vascular smooth muscle relaxation. Pharmacol. Ther. 48:1990;237-258.
7. + currents in vascular smooth muscle and endothelial cells. Br. J. Pharmacol. 125:1998;106P.
8. Faraci F.M., Heistad D.D. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol. Rev. 78:1998;53-97.
9. + channels in aortic endothelial cells. J. Membr. Biol. 98:1987;125-133.
10. Garthwaite J., Southam E., Boulton C.L., Nielsen E.B., Schmidt K., Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4)oxadiazolo-[4,3-a]quinoxalin-1-one. Mol. Pharmacol. 48:1995;184-188.
11. + channels. Proc. R. Soc. Biol. Sci. 242:1990;23-28.
12. Knaus H.-G., McManus O.B., Lee S.H., Schmalhofer W.A., Garcia-Calvo M., Helms L.M.H., Sanchez M., Giangiacomo K., Reuben J.P., Smith A.B. III, Kaczorowski G.J., Garcia M.L. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 33:1994;5819-5828.
13. Kreye V.A., Gerstheimer F., Weston A.H. Effect of BRL 34915 on resting membrane potential and 86Rb efflux in rabbit tonic vascular smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 335:1987;R64.
14. Kuriyama H., Kitamura K., Nabata H. Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol. Rev. 47:1995;387-573.
15. Laskey R.E., Adams D.J., Cannell M., Van Breemen C. Calcium-entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers. Proc. Natl. Acad. Sci. 89:1992;1690-1694.
16. Laurent F., Michel A., Bonnet P.A., Chapat J.P., Boucard M. Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig trachealis. Br. J. Pharmacol. 108:1993;622-626.
17. Luckhoff A., Busse R. Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential. Pfluegers Arch. 416:1990;305-311.
18. Luckhoff A., Busse R. Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents. Naunyn-Schmiedeberg's Arch. Pharmacol. 342:1990;94-99.
19. Marchenko S.M., Sage S.O. Calcium-activated potassium channels in the endothelium of rat aorta. J. Physiol. 492:1996;53-60.
20. Moro M.A., Russell R.J., Cellek S., Lizasoain I., Su Y., darley-Usmar V.M., Radomski M.W., Moncada S. cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc. Natl. Acad. Sci. 93:1996;1480-1485.
21. 2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone. Trends Cardiovasc. Med. 3:1993;54-60.
22. Nelson M.T., Quayle J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol. 268:1995;C799-C822. Cell Physiol. 37.
23. Nilius B. Permeation properties of a non-selective cation channel in human vascular endothelial cells. Pfluegers Arch. 416:1990;609-611.
24. Nilius B. Regulation of transmembrane calcium fluxes in endothelium. News Physiol. Sci. 6:1991;110-114.
25. + channels by novel benzimidazolone. Eur. J. Pharmacol. 251:1994;53-59.
26. + channels. Trends Pharmacol. Sci. 10:1989;431-435.
27. + currents in rabbit endothelial cells. Jpn. J. Pharmacol. 53:1990;235-246.
28. Ca channels in acutely dissociated neurons from the rat ventromedial hypothalamus by NS 1619. Br. J. Pharmacol. 113:1994;659-661.
29. + channels in arterial smooth muscle. Science. 245:1989;177-180.
30. + channel in cultured vascular endothelial cells. Pfluegers Arch. 422:1992;66-74.