Mechanisms of nose-lung interaction

Allergy: European Journal of Allergy and Clinical Immunology, Supplement

Volumn 54, Issue 57, 1999, Pages 94-105

  Togias, A ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; ANTIHISTAMINIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CROMOGLYCATE DISODIUM; DECONGESTIVE AGENT; GLUCOCORTICOID; METHACHOLINE; NEDOCROMIL; STEROID; THEOPHYLLINE;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ASTHMA; DISEASE PREDISPOSITION; DISEASE SEVERITY; HUMAN; LOWER RESPIRATORY TRACT; LUNG; NOSE; NOSE DISEASE; NOSE PROVOCATION TEST; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; REVIEW;

ANIMALS; ASTHMA; BRONCHI; HUMANS; LUNG; NASAL MUCOSA; NASAL PROVOCATION TESTS; REFLEX; RHINITIS, ALLERGIC, SEASONAL;

EID: 0032721860     PISSN: 01081675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (90)

1. 1. Weille FL. Studies in asthma XIX. the nose and throat in five hundred cases of asthma. N Engl J Med 1936;215:235-239.
2. 2. Edfors-Lubs ML. Allergy in 7000 twin pairs. Acta Allergol 1971;26:249-285.
3. 3. Peckham C, Butler NA. A national study of asthma in childhood. J Epidemiol Commun Hlth 1978;32:79-85.
4. 4. Mullarkey M, Hill J, Webb D. Allergic and nonallergic rhinitis: their characterization with attention to the meaning of nasal eosinophilia. J Allergy Clin Immunol 1980;65:122-126.
5. 5. Montgomery Smith J. Epidemiology and natural history of asthma, allergic rhinitis and atopic dermatitis (eczema). In: Middleton E, Reed CE, Ellis EF, editors. Allergy, principles and practice. St Louis: CV Mosby Co., 1983:772-803.
6. 6. Pedersen P, Weeke E. Asthma and allergic rhinitis in the same patients. European Journal of Allergy and Clinical Immunology 1983;38:25-29.
7. 7. Greisner W, Settipane R, Settipane G. Co-existence of asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Asthma Proc 1998;19:175-179.
8. 8. Kapsali T, Horowitz E, Togias A. Rhinitis is ubiquitous in allergic asthmatics. J Allergy Clin Immunol 1997;99:S1-38.
9. 9. Malo J-L, Lemiere C, Desjardins A, Cartier A. Prevalence and intensity of rhinoconjunctivitis in subjects with occupational asthma. Eur Respir J 1997;10:1513-1515.
10. 10. Gaga M, Lambrou D, Orphanidou H, et al. Cellular infiltration in the nasal mucosa in asthma. Am J Respir Crit Care Med 1998;157:A616.
11. 11. Settipane R, Hagy G, Settipane G. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc 1994;15:21-25.
12. 12. Anderson HR, Pottier AC, Strachan DP. Asthma from birth to age 23: incidence, and relationship to prior and concurrent atopic disease. Thorax 1992;47:537-542.
13. 13. Jenkins MA, Hopper JL, Flander LB, Carlin JB, Giles GC. The associations between childhood asthma and atopy, and parental asthma, hay fever and smoking. Paediatr Perinat Epidemiol 1993;7:67-76.
14. 14. Scichflone N, Sanico AM, Diemer FB, Horowitz E, Togias A. Symptom triggers in rhinitis and asthma (abstract). J Allergy Clin Immunol 1999;103;S8.
15. 15. Stephens L, Proud D, Togias A. Nasal cold, dry air (CDA) challenge results in stronger nasal and pulmonary responses in asthmatics compared to patients with rhinitis (abstract). J Allergy Clin Immunol 1996;97:A315.
16. 16. Sibbald B, Rink E. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history. Thorax 1991;46:895-901.
17. 17. Sampaio F, Proud D, Leopold D, Kim J, Moylan B, Togias A. Asthmatics with rhinosinusitis have worse upper airway disease compared to pateints with rhinosinusitis alone (abstract). ACI International 1997;Suppl. 4:136.
18. 18. Sampaio F, Togias A, Proud D, Kim J, Moylan B, Leopold D. The presence of asthma (AS) is associated with worse olfaction in patients with chronic rhinosinusitis (CR). Proc Int Rhinol Centennial XVI ISIAN 1997.
19. 19. Huse DM, Hartz SE, Russell MW, Piercey G, Weiss S. Allergic rhinitis may worsen asthma symptoms in children: the international asthma outcomes registry (abstract). Am J Respir Crit Care Med 1996;153:A860.
20. 20. Huse DM, Hartz SE, Klaus DH, Piercy GE, Riehner R, Wess ST. Does allergic rhinitis exacerbate asthma symptoms in adults? The asthma outcomes registry (abstract). Eur Respir J 1996;9:351S.
21. 21. Halpern M, Richner R, Togias A, Guo C, de Lissovoy G. Allergic rhinitis may increase asthma costs (abstract). Am J Respir Crit Care Med 1996;153:A860).
22. 22. Naclerio R, Meier H, Kagey-Sobotka A, Adkinson N, Meyers D, Norman P, Lichtenstein L. Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis 1983;128:597-602.
23. 23. Naclerio R, Proud D, Togias A, et al. Inflammatory mediators In late antigen-induced rhinitis. N Engl J Med 1985;313:65-70.
24. 24. Bascom R, Pipkom U, Lichtenstein L, Naclerio R. The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of steroid pretreatment. Am Rev Resp Dis 1988;138:406-412.
25. 25. Togias A, Naclerio R, Proud D, et al. Mediator release during nasal provocation: a model to investigate the pathophysiology of rhinitis. Am J Med 1986;79(Suppl. 6A):26-33.
26. 26. Hoehne JH, C.E R. Where is the allergic reaction in ragweed asthma? J Allergy Clin Immunol 1971;48:36-39.
27. 27. Schumacher M, Cota K, Taussig L. Pulmonary response to nasal-challenge testing of atopic subjects with stable asthma. J Allergy Clin Immunol 1986;78:30-35.
28. 28. Plotkowski L, Dessanges J, Lavaud F, Hanhhart F, Lockhart A. Nasal pollen challenge causes bronchial hyperresponsiveness to methacholine in patients with allergic rhinitis (abstract). Am Rev Respir Dis 1990;141:A652.
29. 29. Corren J, Adinoff A, Irvin C. Changes in bronchial responsiveness following nasal provocation with allergen. J Allergy Clin Immunol 1992;89:611-618.
30. 30. Windom H, Lim-Monbay M, Thompson M, Naclerio R, Togias A. The effect of nasal versus bronchial antigens (Ag) challenge on the asthmatic airways (abstract). J Allergy Clin Immunol 1992;89:334.
31. 31. Noureddine G, Thompson M, Brennan F, Proud D, Kagey-Sobotka A, Lichtenstein L, Naclerio R, Togias A. Nasal antigen challenge in asthmatics: effects of ceterizine (CET) on nasal and pulmonary responses (abstract). J Allergy Clin Immunol 1994;93:177.
32. 32. Corren J, Harris A, Aaronson D, et al. Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma. J Allergy Clin Immunol 1997;100:781-788.
33. 33. Finnerty J, Holgate S. Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. Eur Respir J 1990;3:540-547.
34. 34. Finney M, Anderson S, Black J. Terfenadine modifies airway narrowing induced by the inhalation of nonisotonic aerosols in subjects with asthma. Am Rev Respir Dis 1990;141:1151-1157.
35. 35. Patel K. Terfenadine in exercise-induced asthma. Br Med J 1984;285:1496-1497.
36. 36. Wiebicke W, Poynter A, Montgomery M, Chemick V, Pasterkamp H. Effect of terfenadine on the response to exercise and cold air in asthma. Pediatr Pulmonol 1988;4:225-229.
37. 37. de Bruin-Weller M, Rijssenbeck-Nouwens L, de Monchy J. Lack of effect of cetirizine on early and late asthmatic response after allergen challenge. J Allergy Clin Immunol 1994;94:231-239.
38. 38. Ghosh S, De Vos C, Patel K. Effect of cetirizine on exercise induced bronchoconstriction in patients with asthma (abstract). Am Rev Respir Dis 1990;141:A836.
39. 39. Gong H, Tashkin D, Daupinee B, Djahed B, Wu T. Effects of oral cetirizine, a selective H1 antagonist, on allergen-and exercise-induced bronchoconstriction in subjects with asthma. J Allergy Clin Immunol 1990;85:632-641.
40. 40. Grant J, Nicodemus C, Findlay S, et al. Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. J Allergy Clin Immunol 1995;95:923-932.
41. 41. Malick A, Grant J. Antihistamines in the treatment of asthma. Allergy (Suppl.) 1997;52:55-66.
42. 42. Van Ganse E, Kaufman L, Derde M, Yemault J, Delaunois L, Vineken W. Effects of antihistamines in adult asthma: a meta-analysis of clinical trials. Eur Respir J 1997;10:2216-2224.
43. 43. Spector S, Nicodemus C, Corren J, Schanker H, Rachelesky G, Katz R. Comparison of the bronchodilatory effects of cetirizine, albuterol, and both together versus placebo in patients with mild-to-moderate asthma. J Allergy Clin Immunol 1995;96:174-181.
44. 44. Corren J, Adinoff A, Buchmeier A, Irvin C. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 1992;90:250-256.
45. 45. Foresi A, Pelucchi A, Gherson G, Mastropaqua B, Chiapparino A, Testi R. Once daily intranasal fluticasone propionate (200 μg) reduces nasal symtoms and inflammation increase in bronchial responsiveness during the pollen season in allergic rhintis. J Allergy Clin Immunol 1996;98:274-282.
46. 46. Henriksen J, Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am Rev Respit Dis 1984;130:1014-1018.
47. 47. Welsh P, Stricker W, Chu C, Nacssens J, Reese M, Reed C, Marcoux J. Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. Mayo Clin Proc 1987;62:125-134.
48. 48. Watson WTA, Becker AB, Simons FER. Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness. J Allergy Clin Immunol 1993;91:97-101.
49. 49. Wood R, Eggleston P. The effects of intranasal steroids on nasal and pulmonary responses to cat exposure. Am J Respir Crit Care Med 1995;151:315-320.
50. 50. Galen. On the usefulness of the parts of the body. Ithaca: Cornell University Press, 1968.
51. 51. Proctor D. Physiology of the upper airway. In: Fenn WO, Rahn H, editors. Handbook of physiology. Section 3. Respiration. Washington: American Physiological Society, 1964:309-346.
52. 52. Raphael G, Jeney E, Baraniuk J, Kim I, Meredith S, Kaliner M. Pathophysiology of rhinitis: lactoferrin and lysozyme in nasal secretions. J Clin Invest 1989;84:1528-1535.
53. 53. Brandtzaeg P. The role of humoral mucosal immunity in the induction and maintenance of chronic airway infections. Am J Respir Crit Care Med 1995;151:2081-2087.
54. 54. Brandtzaeg P. Immunocompetent cells of the upper airway: functions in normal and diseased mucosa. Eur Arch Oto-Rhino-Laryngol 1995;252:S8-S21.
55. 55. Peden D, Swiersz M, Ohkubo K, Hahn B, Emery B, Kaliner M. Nasal secretion of the ozone scavenger uric acid. Am Rev Respir Dis 1993;148:455-461.
56. 56. Lundberg J, Rinder J, Weitzberg E, Lundberg J, Alving K. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 1994;152:431-432.
57. 57. Lundberg J, Lundberg J, Settergren G, Alving K, Weitzberg E. Nitric oxide, produced in the upper airways, may act in an "aerocrine" fashion to enhance pulmonary oxygen uptake in humans. Acta Physiol Scand 1995;155:467-469.
58. 58. Shturman-Ellstein R, Zeballos R, Buckley J, Souhrada J. The beneficial effect of nasal breathing on exercise-induced bronchoconstriction. Am Rev Respir Dis 1978;118:65-73.
59. 59. Griffin M, McFadden E, Ingram R. Airway cooling in asthmatic and nonasthmatic subjects during nasal and oral breathing. J Allergy Clin Immunol 1982;69:354-359.
60. 60. Rouadi P, Baroody F, Naureckas T, Abbott D, Solway J, Naelerio R. Allergic subjects have a reduced ability to warm air. J Allergy Clin Immunol 1998;101;S150.
61. 61. Lindberg S, Cervin A, Runer T. Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis. Acta Otolaryngol (Stockh) 1997;117:113-117.
62. 62. Arnal J-F, Flores P, Rami J, Murris-Espin M, Bremont F, Aguilla M, Serrano E, Didier A. Nasal nitric oxide concentration in paranasal sinus inflammatory diseases. Eur Respir J 1999;13:307-312.
63. 63. Henriksen AH, Sue-Chu M, Holmen T, Langhammer A, Bjermer L. Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsivness. Eur Respir J 1999;13:301-306.
64. 64. Rall JE, Gilbert NC, Trump R. Certain aspects of the bronchial reflexes obtained by stimulation of the nasopharynx. J Lab Clin Med 1945;30:953-956.
65. 65. Whicker JH, Kem EB. The nasopulmonary reflex in the awake animal. Ann Otol 1973;82:355-358.
66. 66. Kaufman J, Wright G. The effect of nasal and nasopharyngeal irritation on airway resistance in man. Am Rev Respir Dis 1969;100:626-630.
67. 67. Kaufman J, Chen J, Wright G. The effect of trigeminal resection on reflex bronchoconstriction after nasal and nasopharyngeal irritation in man. Am Rev Respir Dis 1970;101:768-769.
68. 68. Yan K, Salome C. The response of the airways to nasal stimulation in asthmatics with rhinitis. Eur J Respir Dis 1982;64(Suppl. 128):105-109.
69. 69. Nolte D, Berger D. On vagal bronchoconstriction in asthmatic patients by nasal irritation. Eur J Respir Dis 1983;64:110-114.
70. 70. Levi C, Tyler G, Olson L, Saunders N. Lack of airway response to nasal irritation in normal and asthmatic subjects. Aust NZ J Med 1990;20:578-582.
71. 71. Littell N, Carlisle C, Millman R, Braman S. Changes in airway resistance, following nasal provocation. Am Rev Respir Dis 1990;141:580-583.
72. 72. Fontanari P, Burneet H, Zattara-Hartman M, Jammes Y. Changes in airway resistance induced by nasal inhalation of cold dry, or moist air in normal individuals. J Appl Physiol 1996;81:1739-1743.
73. 73. Fontanari P, Zattara-Hartmann M-C, Burnet H, Jammes Y. Nasal eupnoeic inhalation of cold, dry air increases airway resistance in asthmatic patients. Eur Respir J 1997;10:2250-2254.
74. 74. Bucca C, Rolla G, Bugiani M, Olivia A, Scappaticci E, Brussino L. Accuracy of the MIF50 histamine dose-response curve to assess extrathoracic airway hyperresponsiveness (EA-HR) (abstr). Am Rev Respir Dis 1990;141:A730.
75. 75. Bucca C, Rolla G, Scappaticci E, et al. Extrathoracic and intrathoracic airway responsiveness in sinusitis. J Allergy Clin Immunol 1995;95:52-59.
76. 76. Bucca C, Rolla G, DeRose V, Bugiani M. Are asthma-like symptoms due to bronchial or extrathoracic airway dysfunction? Lancet 1995,:791-795.
77. 77. Rolla G, Colagrande P, Scappaticci E, et al. Damage of the pharyngeal mucosa and hyperresponsiveness of airway in sinusitis, J Allergy Clin Immunol 1997;100:52-57.
78. 78. Rolla G, Colagrande PMM, Debernardi V, et al. Extrathoracic airway dysfuntion in cough associated with gastroesophageal reflux. J Allergy Clin Immunol 1998;102:209-209.
79. 79. Sanico A, Togias A. Neuronal dysfunction and its role in rhinitis. In: Oehling AK, Lopez JGH, editors. Proc 1CACI XVI/EAAC1 97 1997:185-190.
80. 80. Sanico A, Lai G, Krishnan S, Togias A. Nasal hyperresponsiveness to capsaicin in active allergic rhinitis (abstract). J Allergy Clin Immunol 1998;101:S150.
81. 81. Sanico A, Philip G, Proud D, Naclerio R, Togias A. Comparison of nasal mucosal responsiveness to neuronal stimulation in nonallergic and allergic rhinitis: effects of capsaicin nasal challenge. Clin Exp Allergy 1998;28:92-100.
82. 82. Sanico AM, Philip G, Lai G, Togias A. Hyperosmolar saline induces reflex nasal secretions, evincing neural hyperresponsiveness in allergic rhinitis. J Appl Physiol 1999;86:1202-1210.
83. 83. Sanico AM, Koliatsos VE, Stanisz AM, Bienenstock J, Togias A. Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. Int Arch Allergy Immunol 1999 (in press).
84. 84. Carney I, Gibson P, Murree-Allen K, Saltos N, Olsson L, Hensley M. A systematic evaluation of mechanisms in chronic cough. Am J Respir Crit Care Med 1997;156:211-216.
85. 85. Huxley EJ, Viroslav J, Gray WR, Pierce AK. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med 1978;64:564-568.
86. 86. Bardin P, VanHeerden B, Joubert J. Absence of pulmonary aspiration of sinus contents in patients with asthma and sinusitis. J Allergy Clin Immunol 1990;86:82-88.
87. 87. Brugman S, Larsen G, Henson P, Honor J, Irvin C. Increased lower airways responsiveness associated with sinusitis in a rabbit model. Am Rev Respir Dis 1993;147:314-320.
88. 88. Durham S, Carroll M, Walsh G, Kay A. Leukocyte activation in allergen-induced late-phase asthmatic reaction. N Engl J Med 1984;311:1398-1402.
89. 89. Cookson W, Craddock C, Benson M, Durham S. Falls in peripheral cosinophil counts parallel the late asthmatic response. Am Rev Respir Dis 1989;139:458-462.
90. 90. Durham S, Locgering D, Dunnette S, Gleich C, Kay A. Blood eosinophils and eosinophil-derived proteins in allergic asthma. J Allergy Clin Immunol 1989;84:931-936.