Antihistamines in the treatment of asthma

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 52, Issue SUPPL. 34, 1997, Pages 55-66

  Malick, Alnoor ^a   Grant, J Andrew ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Adverse; Antihistamines; Asthma; Histamine

Indexed keywords

ANTIHISTAMINIC AGENT; ASTEMIZOLE; AZELASTINE; BROMPHENIRAMINE; CETIRIZINE; CHLORPHENIRAMINE; CLEMASTINE; CYPROHEPTADINE; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOTIFEN; LORATADINE; TERFENADINE;

ASTHMA; CLINICAL TRIAL; HUMAN; PRIORITY JOURNAL; REVIEW;

ASTHMA; CETIRIZINE; CLINICAL TRIALS; HISTAMINE; HISTAMINE H1 ANTAGONISTS; HUMANS;

EID: 0030914488     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1997.tb04812.x     Document Type: Article

References (120)

1. Herxheimer H. Antihistamines in bronchial asthma. Med J 1949;2:901-5.
2. Levy LI, Seabury JH. Spirometrie evaluation of Benadryl in asthma. J Allergy 1947;18:244-50.
3. Schuller DE. The spectrum of antihistamines adversely affecting pulmonary function in asthmatic children [Abstract]. J Allergy Clin Immunol 1983;71:147.
4. Schuller DE. Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children. J Allergy Clin Immunol 1983;72:175-9.
5. Bousquet J, Godard P, Michel FB. Antihistamines in the treatment of asthma. Eur Respir J 1992;5:1137-42.
6. Sly RM, Kemp JP, The American Academy of Allergy and Immunology Committee on Drugs. The use of antihistamines in patients with asthma. J Allergy Clin Immunol 1988;82:481-2.
7. Lantner R, Tobin MC. Pharmacist advice to asthmatics regarding antihistamine use. Ann Allergy 1991;66:411-3.
8. Spector SL, Nicklas RA Eds. Practice parameters for the diagnosis and treatment of asthma. J Allergy Clin Immunol 1995;96:789-91.
9. Holgate ST, Finnerty JP. Antihistamines in asthma. J Allergy Clin Immunol 1989;83:537-47.
10. Howarth PH. Histamine and asthma: an appraisal based on specific Hrreceptor antagonism. Clin Exp Allergy 1990;20(suppl 2):31-41.
11. Meltzer EO. The use of anti-H1 drugs in mild asthma. Allersy 1995;50:41-7.
12. Grant JA, Nicodemus, CF, Findlay SR, et al. Cetirizine in patients with seasonal allergic rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. J Allergy Clin Immunol 1995;95:923-32.
13. Simons FER, Simons KJ. The pharmacology and use of H1-receptor-antagonist drugs. New Engl J Med 1994;330: 1663-70.
14. White MV, Slater JE, Kaliner MA. Histamine and asthma. Am Rev Respir Dis 1987;135:1165-76.
15. Rafferty P, Beasley CR, Holgate ST. The contribution of histamine to bronchoconstriction produced by inhaled allergen and adenosine 5′-monophosphate in asthma. Am Rev Respir Dis 1987;136:369-73.
16. Cockcroft DW, Ruffin RM, Dolovich J, Hargreave FE. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy 1977;7:503-13.
17. Kay AB. Mediators and inflammatory cells in allergic disease. Ann Allergy 1987;59:35-42.
18. Metzger WJ, Richerson HB, Warden K, Monick M, Hunninghake GW. Bronchoalveolar lavage of allergic asthmatic patients following allergen provocation. Chest 1986; 89:477-83.
19. Alam R, Grant, JA. Basophils: biology and function in airway disease in Asthma and Rhinitis. Eds, Busse W, Holgate ST. Cambridge, MA., Blackwell, 1994; pp. 242-251.
20. Durham SR, Lee TH, Cromwell O, et al. Immunologic studies in allergen-induced late phase asthmatic reactions. J Allergy Clin Immunol 1984;74:49-59.
21. Laitinen LA, Heino M, Laitinen A, Kava T, Haathela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985;131:599-606.
22. Humbert M, Grant JA, Taborda-Barata L, Durham SR, et al. High affinity immunoglobulin E receptor (FceRI)-bearing cells in bronchial biopsies from atopic and non-atopic ("intrinsic") asthma. Am Rev Respir Crit Care Med, in press.
23. Guo CB, Liu MC, Galli SJ, et al. Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol 1994;10: 384-90.
24. Jarjour NN, Calhoun WJ, Schwartz LB, Busse WW. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction. Am Rev Respir Dis 1991;144:83-7.
25. Falus A, Meretky K. Histamine: an early messenger in inflammatory and immune reactions. Immunol Today 1992; 13:154-6.
26. Larsen JS. Antihistamines: structural classification, pharmacokinetics, and pharmacodynamics. In Antihistamine Update Consensus Conference Proceedings Monograph. September, 1994.
27. Popa VT. Bronchodilating activity of an Hj-blocker chlorpheniramine. J Allergy Clin Immunol 1977;59:54.
28. Groggins RC, Milner AD, Stokes GM. The bronchodilator effects of chlorpheniramine in childhood asthma. Br J Dis Chest 1979;73:297.
29. Nogrady SG, Bevan C. Inhaled antwistamines-broncho-dilation and effects on histamine and methacholine-induced bronchoconstriction. Thorax 1978;33:700.
30. Partridge MR, Saunders KB. Effect of an inhaled antihistamine (clemastine) as a bronchodilator and as maintenance treatment in asthma. Thorax 1979;34:771.
31. Holgate ST. Antihistamines in the treatment of asthma. Clin Rev Allergy 1994;12:65-78.
32. Wood-Baker R, Holgate ST. The comparative actions and adverse effect profile of single doses of Hj-receptor antihistamines in the airways and skin of subjects with asthma. J Allergy Clin Immunol 1993;91:1005-14.
33. Cordoba H, Fernandez M, Santos F, Ochling A. Variations of intracellular histamine basophil levels after treatment with ketotifen. J Invest Aller Clin Immunol 1992;2:87-90.
34. McClean SP, Arreaza EE, Lett-Brown MA, Grant JA. Refractory cholinergic urticaria successfully treated with ketotifen. J Allergy Clin Immunol 1989;83:738-741.
35. Hoshino M. [The effect of ketotifen on the inflammation of bronchial mucosa in atopic asthmatics]. [Japanese]. Arerugi-Japanese J Allergology 1994;43:689-95.
36. Častilo JG, Ochling A, Gamboa PM. Mechanism of ketotifen action in hypersensitivity reactions. Its effect on cellular enzymatic activities. J Investig Allergol Clin Immunol 1991;1:315-23.
37. Craps LP, Ney UM. Ketotifen: current views on its mechanism of action and their therapeutic implications. Respir 1984;45:411-21.
38. Tasaka K, Tomioka H. The Japanese perspective: effects of terfenadine in bronchial asthma: in vitro and in vivo research. Ann Allergy 1993;71:312-6.
39. Efimov W, Blazhko VI, Liashenko MM, Voeikova LS, Bondar TN. [Effect of ketotifen on the eicosanoid system, immunoreactivity and bronchial patency in patients with obstructive pulmonary diseases]. [Russian]. Terapevticheskii Arkhiv 1991;63:70-3.
40. Sole D, Mallozi MC, Toledo EC, Passos Soares FJ, Naspitz CK. Reduction in the oral doses of theophylline in asthmatic children during concomitant treatment with ketotifen. Allergologia et Immunopathologia 1992;20: 57-60.
41. Kasuya S, Izumi S. Steroid-sparing effect of ketotifen in steroid-dependent asthmatics: a long period evaluation in 12 patients. Pharmatherapeutica 1988;5:177-82.
42. Madalinska M, Droszcz W, Felczak-Chazan R. A steroid-sparing effect of ketotifen in steroid dependent asthmatics. Allergol Immunopathol 1985;13:9-11.
43. Rackham A, Brown CA, Chandra RK, Ho P, Hoogerwerf PE, Kennedy RJ, et al. A Canadian multicenter study with Zaditen (ketotifen) in the treatment of bronchial asthma in children aged 5 to 17 years. J Allergy Clin Immunol 1989; 84:286-96.
44. El Hefny A, El Beshlawy A, Nour S, Said M. Ketotifen in the treatment of infants and young children with wheezy bronchitis and bronchial asthma. J Int Med Res 1986; 14:267-73.
45. Volovitz B, Varsano I, Cumella JC, Jaber L. Efficacy and safety of ketotifen in young children with asthma. J Allergy Clin Immunol 1988;81:526-30.
46. Lofrus BG, Price JF. Long-term, placebo-controlled trial of ketotifen in the management of preschool children with asthma. J Allergy Clin Immunol 1987;79:350-5.
47. Burns RB. A multicenter study with ketotifen (Zaditen). New Engl Regional Allergy Proc 1985;6:78-83.
48. Gozalo Reques F, Colas Sanz C, Senent Sanchez C, Rubio Sotes M, Herrero Lopez T, De Barrio Fernandez M. Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo. Allergy 1985;40:242-9.
49. Lisboa C, Moreno R, Cruz E, Barja S, Sanchez I, Moran J, Ferretti R. Acute effect of ketotifen on the dose-response curve of histamine and methacholine in asthma. Br J Dis Chest 1985;79:235-43.
50. Graff-Lonnevig V, Hedlin G. The effect of ketotifen on bronchial hyperreactivity in childhood asthma. J Allergy Clin Immunol 1985;76:59-63.
51. Iikura Y, Naspitz CK, Mikawa H, Talaricoficho S, Baba M, Sole D, et al. Prevention of asthma by ketotifen in infants with atopic dermatitis. Ann Allergy 1992;68:233-6.
52. Iikura Y, Baba M, Mikawa H, Nishima S, Maeda K, Akasaka T, et al. [A double blind study of the effectiveness of ketotifen in preventing the development of asthma in atopic dermatitis patients]. [Japanese]. Arerugi - Jpn J Allergology 1991;40:132-40.
53. Bustos GJ, Bustos D, Bustos GJ, Romero O. Prevention of asthma with ketotifen in preasthmatic children: a three-year follow-up study. Clin Exp Allergy 1995;25:568-73.
54. Woodward J, Munro N. Terfenadine, the first non-sedating antihistamine. Drug Res 1982;32:1154-6.
55. Bousquet J, Emonot A, Germouty J, et al. Double-blind multicenter study of cetirizine in grass-pollen-induced asthma. Ann Allergy 1990;65:504-8.
56. Kurzeja A, Riedelsheimer B, Hulhoven R, Bernheim J. Cetirizine in pollen-associated asthma [Letter]. Lancet 1989;1:556.
57. Dijkman JH, Hekking PRM, Molkenboer JF, et al. Prophylactic treatment of grass pollen-induced asthma with cetirizine. Clin Exp Allergy 1990;20:483-90.
58. Spector S, Lee N, McNutt B, Katz RM, Huster W, Siegel S, et al. Effect of terfenadine in asthmatic patients. Arm Allergy 1992;69:212-6.
59. Patel KR. Effect of terfenadine on methacholine-induced bronchoconstriction in asthma. J Allergy Clin Immunol 1987;79:355-8.
60. Rafferty P, Holgate ST. Terfenadine (Seldane) is a potent and selective histamine Ht receptor antagonist in asthmatic airways. Am Rev Resp Dis 1987;135:181-4.
61. Wood-Baker R, Smith R, Holgate ST. A double-blind, placebo-controlled study of the effect of the specific histamine Hj-receptor antagonist, terfenadine, in chronic severe asthma. Br J Clin Pharmacol 1995;39:671-5.
62. Ruffin RE, Latimer KM. Lack of effect of 4 weeks of oral Hj antagonist on bronchial responsiveness. Eur Respir J 1991;4:575-9.
63. Teale C, Morrison JF, Pearson SB. Effects of Hi-receptor blockade with terfenadine in nocturnal asthma. Br J Clin Phar 1991;32:317-23.
64. Eiser N. The effect of a beta 2-adrenergic agonist and a histamine Hrreceptor antagonist on the late asthmatic response to inhaled antigen. Resp Medicine 1991;85:393-9.
65. 1 receptor antagonist, terfenadine, on antigen-induced asthma. Br J Dis Chest 1986;80:375-84.
66. MacFarlane PI, Heaf DP. Selective histamine blockade in childhood asthma: the effect of terfenadine on resting bronchial tone and exercise induced bronchoconstriction. Respir Med 1989;83:19-24.
67. Finnerty JP, Holgate ST. Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination. Eur Respir J 1990;3:540-7.
68. Taytard A, Beaumont D, Pujet JC, Sapene M, Lewis PJ. Treatment of bronchial asthma with terfenadine: a randomized controlled trial. Br J Clin Pharmacol 1987;24:743-6.
69. 1-receptor antagonist in the treatment of grass pollen sensitive asthma. Br J Clin Pharmacol 1990;30:229-35.
70. Barbey J. Antihistamines: cardiovascular effects. In Antihistamine Update Consensus Conference Proceedings Monograph. September 1994.
71. Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993; 269:1532-6.
72. Simons FER. HrReceptor antagonists comparitive toler-ability and safety. Drug Safety 1994;10(5):350-80.
73. Clee MD, Ingram CG, Reid C, Robertson AS. The effect of astemizole on exercise-induced asthma. Br J Dis Chest 1984;78:180-3.
74. Richards DM, Brogden RN, Heel RC, et al. Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs 1984;28:38-61.
75. Vanderschueren R, Nierop RV, Bussche GV. Astemizole in asthmatic patients. Effect on histamine and allergen challenge. J Drug Therapy Res 1986;11:432-5.
76. Marcelle R, Lecomte J. Propriétés antihistaminiques de l'astémizole chez l'asthmatique asymptomatique. Fr Allergol 1983;23:15.
77. Backer V, Bach-Mortensen N, Becker U, et al. The effect of astemizole on bronchial hyperresponsiveness and exercise-induced asthma in children. Allergy 1989;44:209-13.
78. Benoit C, Malo JL, Ghezzo H, Cartier A. Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects. Chest 1992;101:1318-25.
79. Cisteró A, Abadías M, Lleonart R, Lafuente V, Pintó E, TorrenT J, et al. Effect of astemizole on allergic asthma. Ann Allergy 1992;69:123-7.
80. Dirksen A, Engel T, Frolund L, Heinig JH, Svendsen UG, Weeke B. Effect of a non-sedative antihistaminic (lorata-dine) in moderate asthma. A double-blind controlled clinical crossover trial. Allergy 1989;44:566-71.
81. Town GI, Holgate ST. Comparison of the effect of lorata-dine on the airway and skin responses to histamine, methacholine and allergen in subjects with asthma. J Allergy Clin Immunol 1990;86:886-93.
82. Ekström T, Osterman K, Zetterström O. Lack of effect of loratadine on moderate to severe asthma. Ann Allergy Asthma Immunol 1995;75:287-9.
83. Siergiejko Z, Michalska I, Buko Z, Swiderska M, Chyrek-Borowska S. [The effect of loratadine on skin and bronchial reactivity and histamine liberation from basophils in patients with atopic asthma and allergic rhinitis]. [Polish] Pneumonologia I Alegologia Polska 1994;62:583-8.
84. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J, Wojciechowska B. [Effect of loratadine-selective antagonist of histamine (Hj) receptor-on allergen-induced bronchoconstriction in atopic asthmatics]. [Polish] Pneumonologia I Alergologia Polska 1992;60:11-15.
85. Kroll VM, Nothofer B, Werdermann K. [Allergic bronchial asthma treated with Loratadine]. [German] Fortschritte der Medizin 1993;111:76-8.
86. Chand N, Diamantis W, Sofia RD. Antagonism of histamine and leukotrienes by azelastine in guinea pig ileum. Agents Actions 1986;19:164-8.
87. Spector SL, Perhach JL, Rohr AS, Rachelefsky GS, Katz RM, Siegel SC. Pharmacodynamic evaluation of azelastine in subjects with asthma. J Allergy Clin Immunol 1987;80:75-80.
88. Magnussen H, Reuss G, Jorres R, Aurich R. Duration of the effect of a single dose of azelastine on histamine-induced bronchoconstriction. J Allergy Clin Immunol 1989;83:467-71.
89. 4. Int Arch Allergy Appi Immunol 1987;83:284-9.
90. Chand N, Diamantis W, Sofia RD. Modulation of in vitro anaphylaxis of guinea-pig isolated tracheal segments by azelastine, inhibitors of arachidonic acid metabolism and selected antiallergic drugs. Br J Pharmacol 1986;87:443-8.
91. Chand N, Nolan K, Diamantis W, Perhach JL, Sofia RD. Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. Allergy 1986;41:473-8.
92. Chand N, Pillar J, Diamantis W, Perhach JL, Sofia RD. Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine: implications for its mode of action. Eur J Pharmacol 1983;96:227-33.
93. Fields DAS, Pillar J, Diamantis W, Perhach JL, Sofia RD, Chand N. Inhibition by azelastine of nonallergic histamine release from rat peritoneal mast cells. J Allergy Clin Immunol 1984;73:400-3.
94. Chand N, Pillar J, Diamantis W, Sofia RD. Inhibition of IgE-mediated allergic histamine release from rat peritoneal mast cells by azelastine and selected antiallergic drugs. Agents Actions 1985;16:318-22.
95. Chand N, Pillar J, Diamantis W, Sofia RD. Inhibition of allergic histamine release by azelastine and selected antiallergic drugs from rabbit leukocytes. Int Arch Allergy Appi Immunol 1985;77:451-5.
96. Chand N, Harrison JE, Rooney SM, Sofia RD, Diamantis W. Inhibition of passive cutaneous anaphylaxis (PCA) by azelastine: dissociation of its antiallergic activities from antihistaminic and antiserotonin properties. Int J Immuno-pharmacol 1985;7:833-8.
97. 4 in patients with extrinsic asthma. Thorax 1988;43:306-11.
98. Rafferty P, Holgate ST. The inhibitory effect of azelastine hydrochloride on histamine- and allergen-induced bronchoconstriction in atopic asthma. Clin Exp Allergy 1989; 19:315-20.
99. Magnussen H. The inhibitory effect of azelastine and ketotifen on histamine-induced bronchoconstriction in asthmatic patients. Chest 1987;91:855-8.
100. Oilier S, Gould CAL, Davis RJ. The effect of single and multiple dose therapy with azelastine on the immediate asthmatic response to allergen provocation testing. J Allergy Clin Immunol 1986;78:358-64.
101. Rafferty P, Ng WH, Phillips G, Clough J, Church MK, Aurich R, et al. The inhibitory actions of azelastine hydrochloride on the early and late bronchoconstrictor responses to inhaled allergen in atopic asthma. J Allergy Clin Immunol 1989;84:649-57.
102. Twentyman OP, Oilier S, Holgate ST. The effect of Hr receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. J Allergy Clin Immunol 1993;91:1169-78.
103. Magnussen H, Reuss G, Jorres R, Aurich R. The effect of azelastine on exercise-induced asthma. Chest 1988;93:937-40.
104. Kemp JP, Meltzer EO, Orgel HA, Welch MJ, Bucholtz GA, Middleton E, et al. A dose-response study of the bronchodilator action of azelastine in asthma. J Allergy Clin Immunol 1987;79:893-9.
105. Gould CAL, Oilier S, Aurich R, Davies RJ. A study of the clinical efficacy of azelastine in patients with extrinsic asthma, and its effect on airway responsiveness. Br J Clin Pharmacol 1988;26:515-25.
106. Storms W, Middleton E, Dvorin D, Kemp J, Spector S, Newton J, et al. Azelastine (AZEL) in the treatment of asthma [Abstract]. J Allergy Clin Immunol 1985;75:167.
107. Abramowicz M, Edr. Cetirizine. Med Letter 1996;38: 21-3.
108. Simons FER, McMillan JL, Simons KJ. A double blind, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunol 1990;86:540.
109. Ciprandi G, Buscaglia S, Pesce G, Passalacqua G, Rihoux JP, Bagnasco M, et al. Cetirizine reduces inflammatory cell recruitment and ICAM-1 (or CD54) expression on conjunctival epithelium in both early- and late-phase reactions after allergen-specific challenge. J Allergy Clin Immunol 1995;95(2):612-21.
110. Tan JQ, Reimert CM, Deleuran B, Zachariae C, Simonsen C, Thestruppedersen K. Cetirizine inhibits the in vitro and ex vivo chemotactic response of T lymphocytes and monocytes. J Allergy Clin Immunol 1995;95:979-86.
111. Caproni M, Palleschi GM, Falcos D, Papi C. Lotti T. Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions. Intl J Dermtol 1995;34:510-13.
112. Rédier H, Chanez P, De Vos C, Rifai N, Clauzel AM, Michel FB, et al. Inhibitory effect of cetirizine on the bronchial eosinophilic recruitment induced by allergen inhalation challenge in allergic patients with asthma. J Allergy Clin Immunol 1992;90:215-24.
113. Charlesworth EN, Massey WA, Kagey-Sobotka A, Norman PS, Lichtenstein LM. Effect of Hj.receptor blockade on the early and late response to cutaneous allergen challenge. J Pharmacol Exp Ther 1992;262:964-70.
114. Spector SL, Nicodemus CF, Corren J, Schankei HM, Rachelefsky GS, Katz RM, et al. Comparison of the bronchodilatory effects of cetirizine, albuterol, and both together versus placebo in patients with mild-to-moderate asthma. J Allergy Clin Immunol 1995;96(2):174-81.
115. Kjellmann NM. Is there a place for antihistamine in the treatment of perennial asthma? Pediatr Allergy Immunol 1993;4:38-43.
116. Bruttman G, Pedrali P, Arendt C, Rihoux JP. Protective effect of cetirizine in patients suffering from pollen asthma. Ann Allergy 1990;64(pt II):224-8.
117. Barnes CL, McKenzie CA, Webster KD, Poinsett-Holmes K. Cetirizine: a new nonsedating antihistamine. Ann Pharmacother 1993;27:464-70.
118. Finnerty JP, Holgate ST, Rihoux JP. The effect of 2 weeks treatment with cetirizine on bronchial reactivity to metha-choline in asthma. Br J Clin Pharmacol 1990;29:79-84.
119. Sale ME, Barbey JT, Woosley RL, et al. The electrocardiographic effects of cetirizine in normal subjects. Clin Pharmacol Ther 1994;56:295-301.
120. Mylona-Karayanni C, Hadziargurou D, Liapi-Adamidou G, Anagnostakis I, Sinaniotis C, Saxoni-Papageorgiou F. Effect of ketotifen on childhood asthma: a double-blind study. J Asthma 1990;27:87-93.