메뉴 건너뛰기




Volumn 27, Issue 11, 1999, Pages 1646-1654

Flt3 ligand induces the outgrowth of Mac-1+B220+ mouse bone marrow progenitor cells restricted to macrophage differentiation that coexpress early B cell-associated genes

Author keywords

Biphenotypic; Cytokines; Gene expression; Hematopoiesis; Lineage determination

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; CELL SURFACE MARKER; COLONY STIMULATING FACTOR RECEPTOR; FLT3 LIGAND; INTERLEUKIN 6; LEUKOSIALIN; STEM CELL FACTOR;

EID: 0032721768     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00106-X     Document Type: Article
Times cited : (17)

References (50)
  • 1
    • 0024502040 scopus 로고
    • The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
    • Metcalf D. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature. 339:1989;27.
    • (1989) Nature , vol.339 , pp. 27
    • Metcalf, D.1
  • 3
    • 0019428880 scopus 로고
    • A B-cell specific member of the T200 glycoprotein family
    • Coffman R.L., Weissman I.L. A B-cell specific member of the T200 glycoprotein family. Nature. 289:1981;681.
    • (1981) Nature , vol.289 , pp. 681
    • Coffman, R.L.1    Weissman, I.L.2
  • 4
    • 0018758819 scopus 로고
    • Mac-1: A macrophage differentiation antigen identified by monoclonal antibody
    • Springer T., Galfre G., Secher D.S., Milstein C. Mac-1. A macrophage differentiation antigen identified by monoclonal antibody Eur J Immunol. 9:1979;301.
    • (1979) Eur J Immunol , vol.9 , pp. 301
    • Springer, T.1    Galfre, G.2    Secher, D.S.3    Milstein, C.4
  • 5
    • 0026742379 scopus 로고
    • Characterization of several classes of mouse hematopoietic progenitor cells
    • Heimfeld S., Weissman I.L. Characterization of several classes of mouse hematopoietic progenitor cells. Curr Top Microbiol Immunol. 177:1992;95.
    • (1992) Curr Top Microbiol Immunol , vol.177 , pp. 95
    • Heimfeld, S.1    Weissman, I.L.2
  • 7
    • 0028792104 scopus 로고
    • Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics
    • Borrello M.A., Phipps R.P. Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics. J Immunol. 155:1995;4155.
    • (1995) J Immunol , vol.155 , pp. 4155
    • Borrello, M.A.1    Phipps, R.P.2
  • 8
    • 0030049985 scopus 로고    scopus 로고
    • A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
    • Rolink A., Ten Boekel E., Melchers F., Fearon D.T., Krop I., Andersson J. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors. J Exp Med. 183:1996;187.
    • (1996) J Exp Med , vol.183 , pp. 187
    • Rolink, A.1    Ten Boekel, E.2    Melchers, F.3    Fearon, D.T.4    Krop, I.5    Andersson, J.6
  • 11
    • 0032519768 scopus 로고    scopus 로고
    • C-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
    • Lyman S.D., Jacobsen S.E. c-kit ligand and Flt3 ligand. stem/progenitor cell factors with overlapping yet distinct activities Blood. 91:1998;1101.
    • (1998) Blood , vol.91 , pp. 1101
    • Lyman, S.D.1    Jacobsen, S.E.2
  • 12
    • 0029134556 scopus 로고
    • Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors
    • Gabbianelli M., Pelosi E., Montesoro E., Valtieri M., Luchetti L., Samoggia P., Vitelli L., Barberi T., Testa U., Lyman S., Peschle C. Multi-level effects of flt3 ligand on human hematopoiesis. expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors Blood. 86:1995;1661.
    • (1995) Blood , vol.86 , pp. 1661
    • Gabbianelli, M.1    Pelosi, E.2    Montesoro, E.3    Valtieri, M.4    Luchetti, L.5    Samoggia, P.6    Vitelli, L.7    Barberi, T.8    Testa, U.9    Lyman, S.10    Peschle, C.11
  • 13
    • 0028923125 scopus 로고
    • The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors
    • Jacobsen S.E., Okkenhaug C., Myklebust J., Veiby O.P., Lyman S.D. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro. synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors J Exp Med. 181:1995;1357.
    • (1995) J Exp Med , vol.181 , pp. 1357
    • Jacobsen, S.E.1    Okkenhaug, C.2    Myklebust, J.3    Veiby, O.P.4    Lyman, S.D.5
  • 14
    • 0031977152 scopus 로고    scopus 로고
    • Distinct actions of Flt3 ligand and stem cell factor on myeloid lineage selection and maturation of granulocytes versus macrophages
    • Dannaeus K., Nilsson K., Jönsson J.-I. Distinct actions of Flt3 ligand and stem cell factor on myeloid lineage selection and maturation of granulocytes versus macrophages. Exp Hematol. 26:1998;1522.
    • (1998) Exp Hematol , vol.26 , pp. 1522
    • Dannaeus, K.1    Nilsson, K.2    Jönsson, J.-I.3
  • 15
    • 0028952954 scopus 로고
    • The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors
    • Hirayama F., Lyman S.D., Clark S.C., Ogawa M. The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood. 85:1995;1762.
    • (1995) Blood , vol.85 , pp. 1762
    • Hirayama, F.1    Lyman, S.D.2    Clark, S.C.3    Ogawa, M.4
  • 16
    • 0029670722 scopus 로고    scopus 로고
    • Flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
    • Hunte B.E., Hudak S., Campbell D., Xu Y., Rennick D. Flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J Immunol. 156:1996;489.
    • (1996) J Immunol , vol.156 , pp. 489
    • Hunte, B.E.1    Hudak, S.2    Campbell, D.3    Xu, Y.4    Rennick, D.5
  • 17
    • 0029957070 scopus 로고    scopus 로고
    • Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7
    • Ray R.J., Paige C.J., Furlonger C., Lyman S.D., Rottapel R. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7. Eur J Immunol. 26:1996;1504.
    • (1996) Eur J Immunol , vol.26 , pp. 1504
    • Ray, R.J.1    Paige, C.J.2    Furlonger, C.3    Lyman, S.D.4    Rottapel, R.5
  • 18
    • 0030267526 scopus 로고    scopus 로고
    • The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
    • Veiby O.P., Jacobsen F.W., Cui L., Lyman S.D., Jacobsen S.E. The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta. J Immunol. 157:1996;2953.
    • (1996) J Immunol , vol.157 , pp. 2953
    • Veiby, O.P.1    Jacobsen, F.W.2    Cui, L.3    Lyman, S.D.4    Jacobsen, S.E.5
  • 19
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian K., Hardin J.D., Moore K.A., Boast S., Goff S.P., Lemischka I.R. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 3:1995;147.
    • (1995) Immunity , vol.3 , pp. 147
    • Mackarehtschian, K.1    Hardin, J.D.2    Moore, K.A.3    Boast, S.4    Goff, S.P.5    Lemischka, I.R.6
  • 21
    • 0026041826 scopus 로고
    • Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
    • Okada S., Nakauchi H., Nagayoshi K., Nishikawa S., Nishikawa S., Miura Y., Suda T. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood. 78:1991;1706.
    • (1991) Blood , vol.78 , pp. 1706
    • Okada, S.1    Nakauchi, H.2    Nagayoshi, K.3    Nishikawa, S.4    Nishikawa, S.5    Miura, Y.6    Suda, T.7
  • 22
    • 0023872192 scopus 로고
    • Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
    • Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol. 18:1988;97.
    • (1988) Eur J Immunol , vol.18 , pp. 97
    • Karasuyama, H.1    Melchers, F.2
  • 23
    • 0023852998 scopus 로고
    • Pre-B cell generation potentiated by soluble factors from a bone marrow stromal cell line
    • Landreth K.S., Dorshkind K. Pre-B cell generation potentiated by soluble factors from a bone marrow stromal cell line. J Immunol. 140:1988;845.
    • (1988) J Immunol , vol.140 , pp. 845
    • Landreth, K.S.1    Dorshkind, K.2
  • 24
    • 0030682470 scopus 로고    scopus 로고
    • Bidirectional effect of interleukin-10 on early murine B-cell development: Stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells
    • Veiby O.P., Borge O.J., Mårtensson A., Beck E.X., Schade A.E., Grzegorzewski K., Lyman S.D., Mårtensson I.L., Jacobsen S.E. Bidirectional effect of interleukin-10 on early murine B-cell development. stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells Blood. 90:1997;4321.
    • (1997) Blood , vol.90 , pp. 4321
    • Veiby, O.P.1    Borge, O.J.2    Mårtensson, A.3    Beck, E.X.4    Schade, A.E.5    Grzegorzewski, K.6    Lyman, S.D.7    Mårtensson, I.L.8    Jacobsen, S.E.9
  • 25
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li Y.S., Hayakawa K., Hardy R.R. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 178:1993;951.
    • (1993) J Exp Med , vol.178 , pp. 951
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 26
    • 0031201060 scopus 로고    scopus 로고
    • A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors
    • Melamed D., Kench J.A., Grabstein K., Rolink A., Nemazee D. A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors. J Immunol. 159:1997;1233.
    • (1997) J Immunol , vol.159 , pp. 1233
    • Melamed, D.1    Kench, J.A.2    Grabstein, K.3    Rolink, A.4    Nemazee, D.5
  • 27
    • 0029055859 scopus 로고
    • Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7
    • Orlic D., Anderson S., Biesecker L.G., Sorrentino B.P., Bodine D.M. Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7. Proc Natl Acad Sci U S A. 92:1995;4601.
    • (1995) Proc Natl Acad Sci U S a , vol.92 , pp. 4601
    • Orlic, D.1    Anderson, S.2    Biesecker, L.G.3    Sorrentino, B.P.4    Bodine, D.M.5
  • 28
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy R.R., Carmack C.E., Shinton S.A., Kemp J.D., Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med. 173:1991;1213.
    • (1991) J Exp Med , vol.173 , pp. 1213
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 30
    • 0025732935 scopus 로고
    • The role of recombinant stem cell factor in early B cell development: Synergistic interaction with IL-7
    • McNiece I.K., Langley K.E., Zsebo K.M. The role of recombinant stem cell factor in early B cell development. synergistic interaction with IL-7 J Immunol. 146:1991;3785.
    • (1991) J Immunol , vol.146 , pp. 3785
    • McNiece, I.K.1    Langley, K.E.2    Zsebo, K.M.3
  • 31
    • 0026542446 scopus 로고
    • Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis
    • Billips L.G., Petitte D., Dorshkind K., Narayanan R., Chiu C.-P., Landreth K.S. Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis. Blood. 79:1992;1185.
    • (1992) Blood , vol.79 , pp. 1185
    • Billips, L.G.1    Petitte, D.2    Dorshkind, K.3    Narayanan, R.4    Chiu, C.-P.5    Landreth, K.S.6
  • 32
    • 0028226467 scopus 로고
    • Stromal cell independent growth of bipotent B cell-macrophage precursors from murine fetal liver
    • Kee B.L., Cumano A., Iscove N.N., Paige C.J. Stromal cell independent growth of bipotent B cell-macrophage precursors from murine fetal liver. Int Immunol. 6:1994;401.
    • (1994) Int Immunol , vol.6 , pp. 401
    • Kee, B.L.1    Cumano, A.2    Iscove, N.N.3    Paige, C.J.4
  • 33
    • 0029793903 scopus 로고    scopus 로고
    • Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells
    • Veiby O.P., Lyman S.D., Jacobsen S.E. Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. Blood. 88:1996;1256.
    • (1996) Blood , vol.88 , pp. 1256
    • Veiby, O.P.1    Lyman, S.D.2    Jacobsen, S.E.3
  • 34
    • 0025110360 scopus 로고
    • The influence of S17 stromal cells and interleukin 7 on B cell development
    • Cumano A., Dorshkind K., Gillis S., Paige C.J. The influence of S17 stromal cells and interleukin 7 on B cell development. Eur J Immunol. 20:1990;2183.
    • (1990) Eur J Immunol , vol.20 , pp. 2183
    • Cumano, A.1    Dorshkind, K.2    Gillis, S.3    Paige, C.J.4
  • 35
    • 0026000034 scopus 로고
    • The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells
    • Rolink A., Streb M., Nishikawa S., Melchers F. The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells. Eur J Immunol. 21:1991;2609.
    • (1991) Eur J Immunol , vol.21 , pp. 2609
    • Rolink, A.1    Streb, M.2    Nishikawa, S.3    Melchers, F.4
  • 36
    • 0028466384 scopus 로고
    • Analysis of the B-cell progenitor compartment at the level of single cells
    • Ehlich A., Martin V., Müller W., Rajewsky K. Analysis of the B-cell progenitor compartment at the level of single cells. Curr Biol. 4:1994;573.
    • (1994) Curr Biol , vol.4 , pp. 573
    • Ehlich, A.1    Martin, V.2    Müller, W.3    Rajewsky, K.4
  • 37
    • 0040457178 scopus 로고    scopus 로고
    • A transgenic marker for mouse B lymphoid precursors
    • Mårtensson I.-L., Melchers F., Winkler T.H. A transgenic marker for mouse B lymphoid precursors. J Exp Med. 185:1997;653.
    • (1997) J Exp Med , vol.185 , pp. 653
    • Mårtensson, I.-L.1    Melchers, F.2    Winkler, T.H.3
  • 38
    • 0032567938 scopus 로고    scopus 로고
    • Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    • Corcoran A.E., Riddell A., Krooshoop D., Venkitaraman A.R. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 391:1998;904.
    • (1998) Nature , vol.391 , pp. 904
    • Corcoran, A.E.1    Riddell, A.2    Krooshoop, D.3    Venkitaraman, A.R.4
  • 40
    • 0026011211 scopus 로고
    • Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo
    • Rolink A., Kudo A., Karasuyama H., Kikuchi Y., Melchers F. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10:1991;327.
    • (1991) EMBO J , vol.10 , pp. 327
    • Rolink, A.1    Kudo, A.2    Karasuyama, H.3    Kikuchi, Y.4    Melchers, F.5
  • 41
    • 0026561448 scopus 로고
    • Bipotential precursors of B cells and macrophages in murine fetal liver
    • Cumano A., Paige C.J., Iscove N.N., Brady G. Bipotential precursors of B cells and macrophages in murine fetal liver. Nature. 356:1992;612.
    • (1992) Nature , vol.356 , pp. 612
    • Cumano, A.1    Paige, C.J.2    Iscove, N.N.3    Brady, G.4
  • 42
    • 0022478792 scopus 로고
    • Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes
    • Holmes K.L., Pierce J.H., Davidson W.F., Morse H.C. Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes. J Exp Med. 164:1986;443.
    • (1986) J Exp Med , vol.164 , pp. 443
    • Holmes, K.L.1    Pierce, J.H.2    Davidson, W.F.3    Morse, H.C.4
  • 43
    • 0025339731 scopus 로고
    • Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages
    • Principato M., Cleveland J.L., Rapp U.R., Holmes K.L., Pierce J.H., Morse H.C., Klinken S.P. Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages. Mol Cell Biol. 10:1990;3562.
    • (1990) Mol Cell Biol , vol.10 , pp. 3562
    • Principato, M.1    Cleveland, J.L.2    Rapp, U.R.3    Holmes, K.L.4    Pierce, J.H.5    Morse, H.C.6    Klinken, S.P.7
  • 44
    • 0028924203 scopus 로고
    • Lymphoproliferative disorders in IL-7 transgenic mice: Expansion of immature B cells which retain macrophage potential
    • Fisher A.G., Burdet C., Bunce C., Merkenschlager M., Ceredig R. Lymphoproliferative disorders in IL-7 transgenic mice. expansion of immature B cells which retain macrophage potential Int Immunol. 7:1995;415.
    • (1995) Int Immunol , vol.7 , pp. 415
    • Fisher, A.G.1    Burdet, C.2    Bunce, C.3    Merkenschlager, M.4    Ceredig, R.5
  • 46
    • 0028178485 scopus 로고
    • Demonstration that Thy(lo) subsets of mouse bone marrow that express high levels of lineage markers are not significant hematopoietic progenitors
    • Morrison S.J., Lagasse E., Weissman I.L. Demonstration that Thy(lo) subsets of mouse bone marrow that express high levels of lineage markers are not significant hematopoietic progenitors. Blood. 83:1994;3480.
    • (1994) Blood , vol.83 , pp. 3480
    • Morrison, S.J.1    Lagasse, E.2    Weissman, I.L.3
  • 47
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • Li Y.S., Wasserman R., Hayakawa K., Hardy R.R. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 5:1996;527.
    • (1996) Immunity , vol.5 , pp. 527
    • Li, Y.S.1    Wasserman, R.2    Hayakawa, K.3    Hardy, R.R.4
  • 48
    • 0027930491 scopus 로고
    • Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms
    • Rossner M.T., McArthur G.A., Allen J.D., Metcalf D. Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms. Cell Growth Differ. 5:1994;549.
    • (1994) Cell Growth Differ , vol.5 , pp. 549
    • Rossner, M.T.1    McArthur, G.A.2    Allen, J.D.3    Metcalf, D.4
  • 49
    • 0032530734 scopus 로고    scopus 로고
    • Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand
    • Hawley T.S., Fong A.Z.C., Griesser H., Lyman S.D., Hawley R.G. Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand. Blood. 92:1998;2003.
    • (1998) Blood , vol.92 , pp. 2003
    • Hawley, T.S.1    Fong, A.Z.C.2    Griesser, H.3    Lyman, S.D.4    Hawley, R.G.5
  • 50
    • 0032541471 scopus 로고    scopus 로고
    • Induction of Early B cell factor (EBF) and multiple lineage genes by the basic helix-loop-helix transcription factor E12
    • Kee B.L., Murre C. Induction of Early B cell factor (EBF) and multiple lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med. 188:1998;69.
    • (1998) J Exp Med , vol.188 , pp. 69
    • Kee, B.L.1    Murre, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.