Effect of clofibrate on malic enzyme and leptin mRNAs level in rat brown and white adipose tissue

Hormone and Metabolic Research

Volumn 31, Issue 10, 1999, Pages 538-542

  Kochan, Z ^a   Karbowska, J ^a   Swierczynski, J ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

BAT; Clofibrate; Leptin; Malic Enzyme; Ob Gene; Rat; WAT

Indexed keywords

CLOFIBRATE; LEPTIN; MALATE DEHYDROGENASE (DECARBOXYLATING); MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; GENE EXPRESSION; HYPERLIPIDEMIA; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; WHITE ADIPOSE TISSUE;

EID: 0032720636     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978791     Document Type: Article

References (20)

1. Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996; 1302: 93-109
2. Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 1998; 273: 16710-16714
3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432
4. Pelieymounter MA, Culien MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543
5. Stehling O, Doring H, Ertl J, Preibisch G, Schmidt I. Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol 1996; 271: R1770-R1774
6. Levin N, Nelson C, Gurney A, Vandlen R, de Sauvage F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 1996; 93: 1726-1730
7. De Vos P, Lefebvre AM, Miller SG, Guerre-Millo M, Wong K, Saladin R, Hamann LG, Staels B, Briggs MR, Auwerx J. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 1996; 98: 1004-1009
8. Zelewski M, Swierczynski J. The effect of clofibrate feeding on the NADP-linked dehydrogenases activity in rat tissue. Biochim Biophys Acta 1983; 758: 152-157
9. Castelein H, Gulick T, Declercq PE, Mannaerts GP, Moore DD, Baes MI. The peroxisome proliferator activated receptor regulates malic enzyme gene expression. J Biol Chem 1994; 269: 26754-26758
10. Hertz R, Nikodem V, Ben-Ishai A, Berman I, Bar-Tana J. Thyromimetic mode of action of peroxisome proliferators: activation of "malic" enzyme gene transcription. Biochem J 1996; 319: 241-248
11. Ijpenberg A, Jeannin E, Wahli W, Desvergne B. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 1997; 272: 20108-20117
12. Karbowska J, Kochan Z, Zelewski L, Swierczynski J. Tissue-specific effect of clofibrate on rat lipogenic enzyme gene expression. Eur J Pharmacol 1999; 370: 329-336
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159
14. Moinat M, Deng C, Muzzin P, Assimacopoulos-Jeannet F, Seydoux J, Dulloo AC, Giacobino JP, Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Lett 1995; 373: 131-134
15. Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Nat Acad Sci USA 1996; 93: 5793-5796
16. Wing RR, Sinha MK, Considine RV, Lang W, Caro F. Relationship between weight loss maintenance and changes in serum leptin levels. Horm Metab Res 1996; 28: 698-703
17. Igel M, Becker W, Herberg L, Joost H-G. Evidence that reduced leptin levels, but not an aberrant sequence of leptin or its receptor, contribute to the obesity syndrome in MON mice. Horm Metab Res 1996; 28: 669-673
18. Blennemann B, Moon YK, Freake HC. Tissue-specific regulation of fatty acid synthesis by thyroid hormone. Endocrinology 1992; 130: 637-643
19. Blennemann B, Leahy P, Kim TS, Freake HC. Tissue-specific regulation of lipogenic mRNAs by thyroid hormone. Mol Cell Endocrinol 1995; 110: 1-8
20. Swierczynski J, Scislowski PWD, Aleksandrowicz A, Zydowo M. Malic enzyme in brown adipose tissue-purification, some properties and possible physiological role. Int J Biochem 1981; 13: 365-372