-
1
-
-
0026314114
-
Evolution of senescence: Late survival sacrificed for reproduction
-
Kirkwood TBL, Rose MR. Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B Biol Sci 1991;332:15-24.
-
(1991)
Philos Trans R Soc Lond B Biol Sci
, vol.332
, pp. 15-24
-
-
Kirkwood, T.B.L.1
Rose, M.R.2
-
3
-
-
0029890534
-
A network theory of ageing: The interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
-
Kowald A, Kirkwood TBL. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res 1996;316:209-236.
-
(1996)
Mutat Res
, vol.316
, pp. 209-236
-
-
Kowald, A.1
Kirkwood, T.B.L.2
-
4
-
-
0025117953
-
An attempt at a rational classification of theories of ageing
-
Medvedev ZA. An attempt at a rational classification of theories of ageing. Biol Rev 1990;65:375-398.
-
(1990)
Biol Rev
, vol.65
, pp. 375-398
-
-
Medvedev, Z.A.1
-
5
-
-
0029920370
-
Genetic analysis of aging: Role of oxidative damage and environmental stresses
-
Martin GM, Austad SN, Johnson TE. Genetic analysis of aging: role of oxidative damage and environmental stresses. Nat Genet 1996;13:25-34.
-
(1996)
Nat Genet
, vol.13
, pp. 25-34
-
-
Martin, G.M.1
Austad, S.N.2
Johnson, T.E.3
-
6
-
-
0024266283
-
Do mitochondrial DNA fragments promote cancer and aging?
-
Richter C. Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett 1988;241:1-5.
-
(1988)
FEBS Lett
, vol.241
, pp. 1-5
-
-
Richter, C.1
-
7
-
-
0024437033
-
Genetic toxicology of oxygen
-
Joenje H. Genetic toxicology of oxygen. Mutat Res 1989;219:193-208.
-
(1989)
Mutat Res
, vol.219
, pp. 193-208
-
-
Joenje, H.1
-
8
-
-
0025646076
-
Mitochondrial gene mutation: The ageing process and degenerative diseases
-
Linnane AW, Baumer A, Maxwell RJ, et al. Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem Int 1990;22:1067-1076.
-
(1990)
Biochem Int
, vol.22
, pp. 1067-1076
-
-
Linnane, A.W.1
Baumer, A.2
Maxwell, R.J.3
-
9
-
-
0025741445
-
Ageing-associated 5-kb deletion in human liver mitochondrial DNA
-
Yen T-C, Su J-H, King K-L, et al. Ageing-associated 5-kb deletion in human liver mitochondrial DNA. Biochem Biophys Res Commun 1991;178:124-131.
-
(1991)
Biochem Biophys Res Commun
, vol.178
, pp. 124-131
-
-
Yen, T.-C.1
Su, J.-H.2
King, K.-L.3
-
10
-
-
0025758425
-
Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia
-
Hattori K, Tanaka M, Sugiyama S, et al. Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. Am Heart J 1991;121:1735-1742.
-
(1991)
Am Heart J
, vol.121
, pp. 1735-1742
-
-
Hattori, K.1
Tanaka, M.2
Sugiyama, S.3
-
11
-
-
2442728735
-
Modeling mitochondrial DNA mutations
-
Singh KK, ed. Austin, TX: Landes Biomedical Publisher
-
Kirkwood TBL, Kowald A. Modeling mitochondrial DNA mutations. In: Singh KK, ed. Mitochondrial DNA Mutations in Aging, Disease and Cancer. Austin, TX: Landes Biomedical Publisher, 1999.
-
(1999)
Mitochondrial DNA Mutations in Aging, Disease and Cancer
-
-
Kirkwood, T.B.L.1
Kowald, A.2
-
12
-
-
0032533691
-
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy
-
Lee CM, Lopez ME, Weindruch R, et al. Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med 1998;25:964-972.
-
(1998)
Free Radic Biol Med
, vol.25
, pp. 964-972
-
-
Lee, C.M.1
Lopez, M.E.2
Weindruch, R.3
-
13
-
-
0024163051
-
Familial mitochondrial encephalomyopathy (MERF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease
-
Wallace DC, Zheng X, Lott MT, et al. Familial mitochondrial encephalomyopathy (MERF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease. Cell 1988;55:601-610.
-
(1988)
Cell
, vol.55
, pp. 601-610
-
-
Wallace, D.C.1
Zheng, X.2
Lott, M.T.3
-
14
-
-
0024328462
-
Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome
-
Moraes CT, DiMauro S, Zeviani M, et al. Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. N Engl J Med 1989;320:1293-1299.
-
(1989)
N Engl J Med
, vol.320
, pp. 1293-1299
-
-
Moraes, C.T.1
DiMauro, S.2
Zeviani, M.3
-
15
-
-
0025276996
-
Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease
-
Shoubridge EA, Karpati G, Hastings KEM. Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell 1990;62:43-49.
-
(1990)
Cell
, vol.62
, pp. 43-49
-
-
Shoubridge, E.A.1
Karpati, G.2
Hastings, K.E.M.3
-
16
-
-
0026732706
-
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
-
Cortopassi GA, Shibata D, Soong NW, et al. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992;89:7370-7374.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7370-7374
-
-
Cortopassi, G.A.1
Shibata, D.2
Soong, N.W.3
-
17
-
-
0027182560
-
Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
-
Sugiyama S, Takasawa M, Hayakawa M, et al. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem Mol Biol Int 1993;30:937-944.
-
(1993)
Biochem Mol Biol Int
, vol.30
, pp. 937-944
-
-
Sugiyama, S.1
Takasawa, M.2
Hayakawa, M.3
-
18
-
-
0028349234
-
Differential accumulations of 4977-bp deletion in mitochondrial DNA of various tissues in human ageing
-
Lee HC, Pang CY, Hsu HS, et al. Differential accumulations of 4977-bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys Acta 1994;1226:37-43.
-
(1994)
Biochim Biophys Acta
, vol.1226
, pp. 37-43
-
-
Lee, H.C.1
Pang, C.Y.2
Hsu, H.S.3
-
19
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane AW, Marzuki S, Ozawa T, et al. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989;333: 642-645.
-
(1989)
Lancet
, vol.333
, pp. 642-645
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
-
20
-
-
0024541068
-
Mitochondrial DNA mutations and neuromuscular disease
-
Wallace DC. Mitochondrial DNA mutations and neuromuscular disease. Trends Genet 1989;5:9-13.
-
(1989)
Trends Genet
, vol.5
, pp. 9-13
-
-
Wallace, D.C.1
-
21
-
-
0026782895
-
Deleterious mitochondrial DNA mutations accumulate in aging human tissues
-
Arnheim N, Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res 1992;275:157-167.
-
(1992)
Mutat Res
, vol.275
, pp. 157-167
-
-
Arnheim, N.1
Cortopassi, G.2
-
22
-
-
0027525966
-
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
-
Müller-Höcker J, Seibel P, Schneiderbanger K, et al. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch 1993;422:7-15.
-
(1993)
Virchows Arch
, vol.422
, pp. 7-15
-
-
Müller-Höcker, J.1
Seibel, P.2
Schneiderbanger, K.3
-
23
-
-
0031885843
-
Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
-
Brierley EJ, Johnson MA, Lightowlers RN, et al. Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol 1998;43:217-223.
-
(1998)
Ann Neurol
, vol.43
, pp. 217-223
-
-
Brierley, E.J.1
Johnson, M.A.2
Lightowlers, R.N.3
-
24
-
-
0031081410
-
A proposed refinement of the mitochondrial free radical theory of aging
-
de Grey ADNJ. A proposed refinement of the mitochondrial free radical theory of aging. Bioessays 1997;19:161-166.
-
(1997)
Bioessays
, vol.19
, pp. 161-166
-
-
De Grey, A.D.N.J.1
-
25
-
-
0015239454
-
The turnover of mitochondria in a variety of tissues of young adult and aged rats
-
Menzies RA, Gold PH. The turnover of mitochondria in a variety of tissues of young adult and aged rats. J Biol Chem 1971;246:2425-2429.
-
(1971)
J Biol Chem
, vol.246
, pp. 2425-2429
-
-
Menzies, R.A.1
Gold, P.H.2
-
26
-
-
0015131485
-
Mitochondrial studies in senescent mice - II. Specific activity, bouyant density, and turnover of mitochondrial DNA
-
Huemer RP, Lee KD, Reeves AE, et al. Mitochondrial studies in senescent mice - II. Specific activity, bouyant density, and turnover of mitochondrial DNA. Exp Gerontol 1971;6:327-334.
-
(1971)
Exp Gerontol
, vol.6
, pp. 327-334
-
-
Huemer, R.P.1
Lee, K.D.2
Reeves, A.E.3
-
27
-
-
0025309791
-
Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
-
Bandy B, Davison AJ. Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging? Free Radic Biol Med 1990;8:523-539.
-
(1990)
Free Radic Biol Med
, vol.8
, pp. 523-539
-
-
Bandy, B.1
Davison, A.J.2
-
29
-
-
0029082812
-
Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism
-
Guidot DM, Repine JE, Kitlowski AD, et al. Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism. J Clin Invest 1995;96:1131-1136.
-
(1995)
J Clin Invest
, vol.96
, pp. 1131-1136
-
-
Guidot, D.M.1
Repine, J.E.2
Kitlowski, A.D.3
-
30
-
-
85038131043
-
Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the aging of post-mitotic and dividing cells
-
submitted
-
Kowald A, Kirkwood TBL. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the aging of post-mitotic and dividing cells. J Theor Biol (submitted).
-
J Theor Biol
-
-
Kowald, A.1
Kirkwood, T.B.L.2
-
31
-
-
0017782437
-
Evolution of ageing
-
Kirkwood TBL. Evolution of ageing. Nature 1977; 270:301-304.
-
(1977)
Nature
, vol.270
, pp. 301-304
-
-
Kirkwood, T.B.L.1
-
32
-
-
0000754062
-
Repair and its evolution: Survival versus reproduction
-
Townsend CR, Calow P, eds. Oxford, U.K.: Blackwell Scientific
-
Kirkwood TBL. Repair and its evolution: survival versus reproduction. In: Townsend CR, Calow P, eds. Physiological Ecology: An Evolutionary Approach to Resource Use. Oxford, U.K.: Blackwell Scientific 1981: 165-189.
-
(1981)
Physiological Ecology: An Evolutionary Approach to Resource Use
, pp. 165-189
-
-
Kirkwood, T.B.L.1
-
34
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
35
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee H-W, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.-W.3
-
36
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts. A model for senescence
-
von Zglinicki T, Saretzki G, Docke W, et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts. A model for senescence. Exp Cell Res 1995;220:186-193.
-
(1995)
Exp Cell Res
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
|