A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 785-792

  Brimecombe, Jessica C ^a   Potthoff, William K ^a   Aizenman, Elias ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); CYSTEINE; DITHIOTHREITOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; NONHUMAN; OXIDATION REDUCTION REACTION; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CYSTEINE; DITHIONITROBENZOIC ACID; MUTATION; OXIDATION-REDUCTION; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; REDUCING AGENTS; SULFHYDRYL REAGENTS; TIME FACTORS; TRANSFECTION;

EID: 0032717941     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Aizenman E (1994) Redox modulation of the NMDA receptor, in Direct and Allosteric Control of Glutamate Receptors (Palfreyman MG, Reynolds IJ and Skolnik P eds) pp 95-104, CRC Press, Boca Raton, FL.
2. Aizenman E, Hartnett KA, Zhong C, Gallop PM and Rosenberg PA (1992) Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site. J Neurosci 12:2362-2369.
3. Aizenman E, Lipton SA and Loring RH (1989) Selective modulation of NMDA responses by reduction and oxidation. Neuron 2:1257-1263.
4. Arden SR, Sinor JD, Potthoff WK and Aizenman E (1998) Subunit-specific interactions of cyanide with the NMDA receptor. J Biol Chem 273:21505-21511.
5. Boeckman FA and Aizenman E (1994) Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-aspartate receptor. Neurosci Lett 173:189-192.
6. Boeckman FA and Aizenman E (1996) Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits. J Pharmacol Exper Ther 279:515-523.
7. Brimecombe JC, Boeckman FA and Aizenman E (1997) Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors. Proc Natl Acad Sci USA 94:11019-11024.
8. Brimecombe JC, Gallagher MJ, Lynch DR and Aizenman E (1998) An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors. J Pharmacol Exp Therap 286:627-634.
9. Choi YB, Chen HS and Lipton SA (1997) Multiple cysteine residues on different subunits are involved in redox modulation of NR1/NR2A receptors. Soc Neurosci Abstr 23:932.
10. Cik M, Chazot PL and Stephenson FA (1993) Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: A biochemical characterization. Biochem J 296:877-883.
11. Dingledine R, Borges K, Bowie D and Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7-61.
12. Gallagher MJ, Huang H, Pritchett DB and Lynch DR (1996) Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271:9603-9611.
13. Gozlan H, Khazipov R and Ben-Ari Y (1995) Multiple forms of long-term potentiation and multiple regulatory sites of N-methyl-D-aspartate receptors: Role of the redox site. J Neurobiol 26:360-369.
14. Köhr G, Eckardt S, Luddens H, Monyer H and Seeburg PH (1994) NMDA receptor channels: Subunit-specific potentiation by reducing agents. Neuron 12:1031-1040.
15. McBain CJ and Mayer ML (1994) N-methyl-D-aspartic acid receptor structure and function. Physiol Rev 74:723-760.
16. Meguro H, Mori H, Araki K, Kushiya E, Kutsuwada T, Yamazaki M, Kumanishi T, Arakawa M, Sakimura K and Mishina M (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature (Lond) 357:70-74.
17. Michaelis EK (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 54:369-415.
18. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B and Seeburg PH (1992) Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science (Wash DC) 256:1217-1221.
19. Paoletti P, Ascher P and Neyton J (1997) High-affinity zinc inhibition of NMDA NR1/NR2A receptors. J Neurosci 17:5711-5725.
20. Sinor JD, Boeckman FA and Aizenman E (1997) Intrinsic redox properties of N-methyl-D-aspartate receptor can determine the developmental expression of excitotoxicity in rat cortical neurons in vitro. Brain Res 747:297-303.
21. Sullivan JM, Traynelis SF, Chen HS, Escobar W, Heinemann SF and Lipton SA (1994) Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 13:929-936.
22. Tang LH and Aizenman E (1993a) The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro. J Physiol (Lond) 465:303-323.
23. Tang LH and Aizenman E (1993b) Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro. Neuron 11:857-863.
24. Traynelis SF, Burgess MF, Zheng F, Lyuboslaversusky P and Powers JL (1998) Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J Neurosci 18:6163-6175.
25. Zheng F, Gingrich MB, Traynelis SF and Conn PJ (1998) Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nature Neurosci 1:185-191.