The methanol extract of Spiraea prunifolia var. simpliciflora root inhibits the generation of nitric oxide and superoxide in RAW 264.7 cells

Journal of Ethnopharmacology

Volumn 68, Issue 1-3, 1999, Pages 209-217

  So, Hong Seob ^a   Park, Raekil ^a   Oh, Hyun Mee ^a   Pae, Hyun Ock ^a   Lee, Jae Hyung ^b   Chai, Kyu Yun ^a   Chung, Sang Young ^c   Chung, Hun Taeg ^a  

^a Wonkwang University   (South Korea)

^b LG Chemical Ltd   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

Nitric oxide; Spiraea prunifolia var. simpliciflora; Superoxide

Indexed keywords

GAMMA INTERFERON; METHYLTHIAZOL 2 YL 2,5 DIPHENYLTETRAZOLIUM BROMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLANT EXTRACT; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; ENZYME INHIBITION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PLANT ROOT; TRADITIONAL MEDICINE;

ANALGESICS, NON-NARCOTIC; ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERFERON TYPE II; MACROPHAGES; MEDICINE, TRADITIONAL; METHANOL; MICE; MYRISTIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANT ROOTS; SOLUBILITY; SUPEROXIDES; TIME FACTORS;

EID: 0032717786     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00101-4     Document Type: Article

References (26)

1. Adams D.O., Hamilton T.A. The cell biology of macrophage activation. Annual Review of Immunology. 2:1984;283-318.
2. Bastian N.R., Hibbs J.B. Jr. Assembly and regulation of NADPH oxidase and nitric oxide synthase. Current Opinion in Immunology. 6:1994;131-139.
3. Dinarello C.A., Bunn P.A. Jr. Fever. Seminars in Oncology. 24:1997;288-298.
4. Jun C.D., Choi B.M., Ryu H., Um J.Y., Kwak H.J., Lee B.S., Paik S.G., Kim H.M., Chung H.T. Synergistic cooperation between phorbol ester and IFN-γ for induction of nitric oxide synthesis in murine peritoneal macrophages. Journal of Immunology. 153:1994;3684-3690.
5. Lalenti A., Moncada S., Di Rosa M. Modulation of adjuvant arthritis by endogenous nitric oxide. British Journal of Pharmacology. 110:1993;701-706.
6. Lin M.T., Lin J.H, Yang Y.L Dexamethasone administered into organum vasculosum laminae terminalis of rabbits induced antipyresis via inhibiting nitric oxide pathway in situ. Neuroscientific Letter. 230:1997;53-56.
7. McCartney-Francis N., Allenm J.B., Mizel D.E., Albina J.E., Xie Q.W., Nathan C.F., Wahl S.M. Suppression of arthritis by an inhibitor of nitric oxide synthase. Journal of Experimental Medicine. 178:1993;749-754.
8. Middleton S.J., Shorthous M., Hunter J.D. Increased nitric oxide synthesis in ulcerative colitis. Lancet. 341:1993;456-466.
9. Miesel R., Hartung R, Kroeger H. Priming of NADPH oxidase by tumor necrosis factor alpha in patients with inflammatory and autoimmune rheumatic diseases. Inflammation. 20:1996;427-438.
10. Miller M.J.S., Clark D.A. Nitric oxide synthase inhibition can initiate or prevent inflammation: role of enzyme source. Agents Actions. 41:1994;C231-C232.
11. Miller M.J.S., Sadowska-Krowicka H., Chotinaruemol S., Kakkis J.L., Clark D.A. Amelioration of chronic ileitis by nitric oxide synthase inhibition. Journal of Pharmacological Experimental Therapy. 264:1993;11-16.
12. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological Review. 43:1991;109-142.
13. Pae H.O., Jun C.D., Yoo J.C., Kwak H.J, Lee S.J., Kook Y.A., Park R.K., Chung H.T. Enhancing and priming of macrophages for superoxide anion production by taxol. Immunopharmacology and Immunotoxicology. 20:1998;27-37.
14. Rachmilewitz D., Stamler J.S., Karmeli F., Mullins M.E., Singel D.J., Loscalzo J., Xavier R.J., Podolsky D.K. Peroxynitrite-induced rat colitis - a new model of colonic inflammation. Gastroenterology. 105:1993;1681-1688.
15. Ro J.S. Studies on the constituents of the spirea plants. Korean Journal of Pharmacology. 13:1982;39.
16. Roediger W.E.W., Lawson M.J., Nance S.H., Radcliffe B.C. Detectable colonic nitrite levels in inflammatory bowel disease-mucosal or bacterial malfunction? Digestion. 35:1986;199-204.
17. Roth, J., Storr, B., Voigt, K., Zeisberger, E., 1998. Inhibition of nitric oxide syntases results in a suppression of interleukin-1 beta-induced fever in rats. Life Science 62, PL.
18. Scammell T.E., Elmquist J.K., Saper C.B. Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever. American Journal of Physiology. 271:1996;R333-R338.
19. Skaper S.O., Facci L., Leon A. Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via nitridergic pathway. Journal of Neurochemistry. 64:1995;266-276.
20. Thompson J.H., Sadowska-Krowicka H., Rossi J., Clark D.A., Miller M.J.S. Inducible nitric oxide synthase gave expression in guinea pig ileitis: a model of IBD prevented by aminoguanidine (abstract). Gastroenterology. 106:1994;A782.
21. Vodovotz Y., Bogdan C., Paik J., Xie Q.W., Nathan C.F. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β Journal of Experimental Medicine. 178:1993;605-613.
22. Weihrauch D., Riedel W. Nitric oxide (NO) and oxygen radicals, but not prostagladins, modulate fever. Annals New York Academy of Science. 813:1997;373-382.
23. White C.R., Brock T.A., Chang L.Y., Crapo J., Briscoe P., Ku D., Bradley W.A., Gianturco S.H., Gore J., Freeman B.A., Tarpey M.M. Superoxide and peroxynitirite in atherosclerosis. Proceedings of National Academy of Science USA. 91:1994;1044-1048.
24. Wizemann M.M., Gardner C.R., Laskin J.D., Quinones S., Durham S.K., Goller L., Ohnishi S.T., Laskin D.L. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. Journal of Leukocytic Biology. 56:1994;759-768.
25. Woo M.H., Lee E.H., Chung S.O., Kim C.W. Constituents of Spiraea Prunifolia var. simpiliciflora. Korean Journal of Pharmacology. 27:1996;389-396.
26. Xia Y., Zweier J.L. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proceedings of National Academy of Science USA. S93:1997;6770-6774.