The effect of inhibitors of multixenobiotic resistance mechanism on the production of mutagens by Dreissena polymorpha in waters spiked with premutagens

Aquatic Toxicology

Volumn 47, Issue 2, 1999, Pages 107-116

  Britvić, Smiljana ^a   Kurelec, Branko ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

2 Aminofluorene; Ames test; Benzo(a)pyrene; Direct mutagenic metabolites; Dreissena polymorpha; Inhibitors; Multi xenobiotic resistance mechanism

Indexed keywords

2 FLUORENYLAMINE; ALPHA NAPHTHOFLAVONE; BENZO[A]PYRENE; CYCLOSPORIN A; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; GLYCOPROTEIN P; MUTAGENIC AGENT; POLYCYCLIC AROMATIC HYDROCARBON; RIVER WATER; VERAPAMIL;

AMES TEST; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INVERTEBRATE; MULTIDRUG RESISTANCE; MUSSEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; WATER POLLUTION; XENOBIOTIC METABOLISM;

DREISSENA POLYMORPHA; INVERTEBRATA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032716725     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-445X(99)00011-9     Document Type: Article

References (44)

1. Ahel M., Giger W. Identification of some specific water pollutants in the River Sava by high-resolution chromatographic techniques and computer assisted mass spectrometry. Kem. Ind. 34:1985;295-309.
2. Anderson R.S. Metabolism of a model environmental carcinogen by bivalve moluscs. Mar. Environ. Res. 17:1985;137-140.
3. Anderson R.S., Döös J.E. Activation of mammalian carcinogens to bacterialmutagens by microsomal enzymes from a pelecypod molusc, Mercenaria mercenaria. Mutat. Res. 116:1983;247-256.
4. Britvić S., Kurelec B. Selective activation of carcinogenic aromatic amines to bacterial mutagens in the marine mussel Mytilus galloprovincialis. Comp. Biochem. Physiol. 85C:1986;111-114.
5. Britvić S., Lucić D., Kurelec B. Bile fluorescence and some early biological effects in fish as indicators of pollution by xenobiotics. Environ. Toxicol. Chem. 12:1993;765-773.
6. Britvić S., Beadini N., Lucić D., Kurelec B. Fluorescence of Fish Bile as Indicator of Pollution by Xenobiotics. SECOTOX Regional Meeting, Rome, Italy, 26-29 September 1993. 1993;133. Abstract Book.
7. Cornwall R., Toomey B.H., Bard S., Bacon C., Jarman W.M., Epel D. Characterisation of multixenobiotic/multidrug transport in the gills of the mussel Mytilus californianus and identification of environmental substrates. Aquat. Toxicol. 31:1995;277-296.
8. Dauberschmidt C., Dietrich D.R., Schlatter C. Investigations on the biotransformation capacity of organophosphates in the mollusc Dreissena polymorpha. Aquat. Toxicol. 37:1997;283-294.
9. Endicott J.A., Ling V. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:1989;137-171.
10. Galgani F., Cornwall R., Toomey B.H., Epel D. Interaction of environmental xenobiotics with a multixenobiotic defense mechanism in the bay mussel Mytilus galloprovincialis from the coast of California. Environ. Toxicol. Chem. 15:1996;325-331.
11. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:1993;385-427.
12. Hofsli E., Nissen-Meyer J. Reversal of multidrug resistance by lipophilic drugs. Cancer Res. 50:1990;3997-4002.
13. Knezovich J.P., Lawton M.P., Harrison F.L. In vivo metabolism of aromatic amines by the bay mussel, Mytilus edulis. Mar. Environ. Res. 24:1988;88-91.
14. Kurelec B. Exclusive activation of aromatic amines in the marine mussel Mytilus edulis by FAD-containing monoxygenase. Biochem. Biophys. Res. Commun. 127:1985;773-778.
15. Kurelec B. The experience with the detection of mutagens in superficial, underground, sea, and drinking water. Hrana i ishrana (in Croatian, with English abstract). 4:1986;229-232.
16. Kurelec B. The multixenobiotic resistance mechanism in aquatic organisms. Crit. Rev. Toxicol. 22:1992;23-43.
17. Kurelec B. The genotoxic disease syndrome. Mar. Environ. Res. 35:1993;341-348.
18. Kurelec B. Reversion of the multixenobiotic resistance mechanism in gills of a marine mussel Mytilus galloprovincialis by a model inhibitor and environmental modulators of P170-glycoprotein. Aquat. Toxicol. 33:1995;93-103.
19. Kurelec B. Pumping-out: the first line cellular defence to water pollutants in aquatic organisms. Toxicol. Ecotoxicol. News. 4:1997;104-109.
20. Kurelec B. A new type of hazardous chemical: the chemosensitizers of multixenobiotic resistance. Environ. Health Perspect. 105:1997;855-860.
21. Kurelec B., Krča S. Metabolic activation of 2-aminofluorene, 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene to bacterial mutagens with the mussel (Mytilus galloprovincialis) and carp (̄Cyprinus carpio) subcellular preparations. Comp. Biochem. Physiol. 88C:1987;171-177.
22. Kurelec B., Pivčević B. Distinct glutathione-dependent enzyme activities and a verapamil sensitive binding of xenobiotics in a fresh-water mussel Anodonta cygnea. Biochem. Biophys. Res. Commun. 164:1989;934-940.
23. Kurelec B., Pivčević B. Evidence for a multixenobiotic resistance mechanism in the mussel Mytilus galloprovincialis. Aquat. Toxicol. 19:1991;291-302.
24. Kurelec B., Pivečvić B. The multidrug resistance-like mechanism in a marine sponge Tethya aurantium. Mar. Environ. Res. 34:1992;249-253.
25. Kurelec B., Britvić S., Zahn R.K. Selective potential for the activation of carcinogenic aromatic amines to bacterial mutagens in some marine invertebrates. Mar. Environ. Res. 17:1985;141-144.
26. Kurelec B., Garg A., Krèa S., Chacko M., Gupta R.C. Natural environment surpasses polluted in inducing DNA damage in fish. Carcinogenesis. 10:1989;1337-1339.
27. Kurelec B., Krča S., Pivčević B., Ugarković ., Bachmann M., Imsiecke G., Müller W.E.G. Expression of P-glycoprotein gene in marine sponges. Identification and characterisation of the 125-kDa drug-binding glycoprotein. Carcinogenesis. 13:1992;69-76.
28. Kurelec B., Britvić S., Pivčević B., Kurelec B. Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment. Mar. Environ. Res. 46:1998;415-419.
29. Livingston D.R. Towards a specific index of impact by organic pollution for marine invertebrates. Comp. Biochem. Physiol. 100C:1991;151-155.
30. Livingston D.R., Farrar S.V. Tissue and subcellular distribution of enzyme activities of mixed-function oxygenase and benzo(a)pyrene metabolism in the common mussel Mytilus edulis L. Sci. Total. Environ. 39:1984;209-235.
31. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
32. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:1983;173-215.
33. Marsh J.W., Chipman J.K., Livingstone D.R. Activation of xenobiotics to reactive and mutagenic products by the marine invertebrates Mytilus edulis, Carcinus maenas and Asterias rubens. Aquat. Toxicol. 22:1991;115-127.
34. Minier C., Moore M.N. Rhodamine B accumulation and MXR protein expression in mussel blood cells - effect of exposure to vincristine. Mar. Ecol. Prog. Ser. 142:1996;165-173.
35. Minier C., Akcha F., Galgani F. P-glycoprotein expression in Crassostrea gigas and Mytilus edulis in polluted seawater. Comp. Biochem. Physiol. 106B:1993;1029-1036.
36. Payne, J.F., 1984. Mixed-function oxygenases in biological monitoring programs: review of potential usage in different phyla of aquatic animals. In: Persone, G., Jaspers, E., Claus, C. (Eds.), Ecotoxicological Testing for the Marine Environment. State Univ. Ghent and Inst. Mar. Scient. Res., Bredene, Belgium, pp. 625-655.
37. Payne J.F., Fancey L.L., Rahimtula A.D., Porter E.L. Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring. Comp. Biochem. Physiol. 86C:1987;233-245.
38. Pelroy R.A., Gandolfi A.J. Use of a mixed function amine oxidase for metabolic activation in the Ames/Salmonella assay system. Mutat. Res. 72:1980;329-334.
39. Protić-Sabljić M., Kurelec B. High mutagenic potency of several polycyclic aromatic hydrocarbons induced by liver postmitochondrial fractions from control and xenobiotic treated immature carp. Mutat. Res. 118:1983;177-189.
40. Shut H.A.J., Castonguay A. Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites. Drug. Metab. Rev. 15:1984;753-839.
41. Smital T., Kurelec B. Inhibitors of the multixenobiotic resistance mechanism in natural waters: in vivo demonstration of their effects. Environ. Toxicol. Chem. 16:1997;2164-2170.
42. Toomey B.H., Epel D. Multixenobiotic resistance in Urechis embryos: protection from environmental toxins. Biol. Bull. 185:1993;355-364.
43. Vandermuelen J.H., Penrose W.R. Absence of aryl hydrocarbon hydroxylase (AHH) in three marine bivalves. J. Fish. Res. Bd Can. 35:1978;643-647.
44. Waldmann P., Pivčević B., Muller W.E.G., Zahn R.K., Kurelec B. Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea. Mutat. Res. 342:1993;113-123.