Suppression of caspase-3 and nitric-oxide synthase-2 during buccal mucosal ulcer healing: Effect of chronic alcohol ingestion

IUBMB Life

Volumn 48, Issue 1, 1999, Pages 121-125

  Slomiany, B L ^a   Piotrowski, J ^a   Slomiany, A ^a  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Alcoholism; Buccal mucosa; Caspase 3; Nitric oxide synthase; Ulcer haling

Indexed keywords

CASPASE 3; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTROOSMOSIS; ENZYME INHIBITION; MOUTH MUCOSA; MOUTH ULCER; NONHUMAN; PROTEIN EXPRESSION; RAT; ULCER HEALING;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; MOUTH MUCOSA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; ORAL ULCER; RATS; RATS, SPRAGUE-DAWLEY; WOUND HEALING;

ANIMALIA;

EID: 0032716570     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/152165499307521     Document Type: Article

References (25)

1. Brooks, P. J. (1997) DNA damage, DNA repair, and alcohol toxicity - a review. Alcohol. Clin. Exp. Res. 21, 1073-1082.
2. Proctor, G., and Shori, D. K. (1995) The effects of ethanol on salivary glands. In Alcohol and Gastrointestinal Trad (Preedy, V. R., and Watson. R. R., eds.). pp. 111-122. CRC Press. Boca Raton, FL.
3. Muller, P., Hepke, B., Beldau, U., and Raabe, G. (1983) Tissue damage in the rabbit oral mucosa by acute and chronic direct toxic action of different alcohol concentrations. Exp. Pathol. 24, 171-191.
4. Slomiany, B. L., Piotrowski, J., and Slomiany, A. (1997) Chronic alcohol ingestion enhances tumor necrosis factor-α expression and salivary gland apoptosis. Alcohol. Clin. Exp. Res. 21, 1530-1533.
5. Slomiany, B. L., Piotrowski, J., Piotrowski, E., and Slomiany, A. (1998) Induction of buccal mucosal apoptosis with chronic alcohol ingestion. Biochem. Mol. Biol. Int. 44, 381-389.
6. Slomiany, B. L., Piotrowski, J., and Slomiany, A. (1998) Alterations in buccal mucosal endothelin-1 and nitric oxide synthase with chronic alcohol ingestion. Biochem. Mol. biol. Int. 45, 681-688.
7. Slomiany, B. L., Piotrowski, J., Piotrowski. E., and Slomiany, A. (1998) Activation of apoptolic caspase-3 and nitric oxide synthase-2 in buccal mucosa with chronic alcohol ingestion. Biochem. Mol. Biol. Int. 45, 1199-1209.
8. Sekkai, D., Aillet, F., Israel, N., and Lepoivre, M. (1998) Inhibition of NFκB and HIV-1 long terminal repeat transcriptional activation by inducible nitric oxide synthase-2-activity. J. Biol. Chem. 273, 3895-3900.
9. Mustafa, S. B., and Olson, M. S. (1998) Expression of nitric-oxide synthase in rat Kupffer cells is regulated by cAMP. J. Biol. Chem. 273, 5073-5080.
10. Mannick, J. B., Miao, Y. Q., and Stamler, J. S. (1997) Nitric oxide inhibits Fas-induced apoptosis. J. Biol. Chem. 272, 24125-24128.
11. Salvesen, G. S., and Dixit, V. M. (1997) Caspases: intracellular signaling by protcolysis. Cell 91, 443-4-46.
12. Thornberry, N. A., and Lazebnik, Y. (1998) Caspases: enemies within. Science 281, 1312-1316.
13. Villa, P., Kaufmann, S. H., and Earnshaw, W. C. (1997) Caspases and caspase inhibitors. TIBS 22, 388-393.
14. Slomiany, B. L., Piotrowski, J., and Slomiany, A. (1998) Effect of chronic alcohol ingestion on buccal mucosal expression of bFGF and Cdk2 during ulcer healing. Biochem. Mol. Biol. Int. 46, 963-971.
15. Konturek, S. J., Pytko-Polonczyk, J., Brzozowski, T., Bielanski, W., and Majka, J. (1993) Healing of oral and gastric ulcers: effects of blood flow, epidermal growth factor and sensory innervation. Gastroenterol. Hepatol. 5 (Suppl. 3), S45-S52.
16. Slomiany, B. L., Piolrowski, J., and Slomiany, A. (1996) Synchronized induction in bFGF and Cdk2 during gastric ulcer healing. Biochem. Mol. Biol. Int. 40, 339-345.
17. Riches, D. W. H., Chan, E. D., Zahradka, E. A., Winston, B. W., Remigio, L. K., and Lake, F. R. (1998) Cooperative signaling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide synthase by mouse macrophages. J. Biol. Chem. 273, 22800-22806.
18. Kim, Y. M., Talanian, R. V., and Billiar, T. R. (1997) Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272, 31138-31148.
19. Salerno, J. C., Harris, D. E., Irizay, K., Patel, B., Morales, A. J., Smith, S. M. E., Martasek, P., Roman, L. J., Masters, B. S. S., Jones, C. L., Weissman, B. A., Lane, P., Liu, Q., and Gross, S. S. (1997) An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. J. Biol. Chem. 272, 29769-29777.
20. Price, K., and Hanson, P. (1998) Constitutive nitric oxide synthases in rat gastric mucosa: subcellular distribution, relative activity and different carbonyl-terminal antigenicity of the neuronal form compared with cerebellum. Digestion 59, 308-313.
21. 2-terminal kinase-mediated activation of interleukin-1β converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis. J. Biol. Chem. 272, 4631-4636.
22. Ashkcnazi, A., and Dixit, V. M. (1998) Death receptors: signaling and modulation. Science 281, 1305-1308.
23. Green, D. R., and Reed, J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
24. + suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272, 30567-30576.
25. Juin, P., Pelletier, M., Oliver, L., Tremhlais, K., Gregorie, M., Melfah, K., and Vallete, F. M. (1998) Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoplosis in a cell-free system. J. Biol. Chem. 273, 17559-17564.