Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 11, 1999, Pages 621-629

  Graeven, Ullrich ^a   Fiedler, Walter ^b   Karpinski, Sonja ^a   Ergün, Süleyman ^b   Kilic, Nerbil ^b   Rodeck, Ulrich ^c   Schmiegel, Wolff ^a   Hossfeld, Dieter Kurt ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Fit 1; KDR; Melanocytes; Melanoma; VEGF

Indexed keywords

GROWTH FACTOR; INSULIN; PLASMINOGEN ACTIVATOR; UROKINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FETAL CALF SERUM; HUMAN; HUMAN CELL; MELANOCYTE; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN VIRUS 40;

ANTIBODY SPECIFICITY; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DNA, ANTISENSE; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MELANOMA; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; URINARY PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032714247     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050325     Document Type: Article

References (43)

1. Andersson S, Davis D, Dahlbäck H, Jörnvall H, Russel DW (1989) Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem 264:8222-8229
2. Bacharach E, Itin A, Keshet E (1992) In vivo pattern of expression urokinase and its inhibitor PAI-1 suggest a concerted role in upregulating physiological angiogenesis. Proc Natl Acad Sci USA 89:10 686-10 690
3. Boocock CA, Charnock-Jones DS, Sharkey AM, McLaren J, Barker PJ, Wright KA, Twentyman PR, Smith SK (1995) Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 87:506-516
4. Brown LF, Berse B, Jackman RW, Tongazzi K, Manseau EJ, Senger DR, Dvorak HF (1993) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53:4727-4735
5. Cheng SH, Huang HJS, Nagane M, Ji XD, Wang D, Shih CCY, Arap W, Huang CM, Cavenee WK (1996) Supression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci USA 93:8502-8507
6. Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, Dvorak HF (1996) Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis and experimental metastasis. Cancer Res 56:172-181
7. Davidoff MS, Schulze W (1990) Combination of the peroxidase anti-peroxidase (PAP)- and avidin-biotin-peroxidase complex (ABC)-techniques: an amplification alternative in immunohistochemical staining. Histochemistry 93:531-536
8. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991
9. Ferrara N, Houck K, Jakeman L, Leung DW (1992) Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrinol Rev 13:18-32
10. Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller GA, Levinson AD (1993) Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest 91:160-170
11. Finkenzeller G, Technau A, Marme D (1995) Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem Biophys Res Commun 208:432-439
12. Gitay-Goren H, Halaban R, Neufeld G (1993) Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors. Biochem Biophys Res Commun 190:702-709
13. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G (1987) Structural characterisation and biologic functions of fibroblast growth factor. Endocrinol Rev 8:95-114
14. Grøndahl-Hansen J, Christensen IJ, Rosenquist C, Brünner N, Mouridsen HT, Danø K, Blichert-Toft M (1993) High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosol extracts of breast carcinomas are assosiated with poor prognosis. Cancer Res 53:2513-2521
15. Hanahan D, Folkmann J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364
16. Herlyn D, Iliopoulos D, Jensen PJ, Parmiter A, Baird J, Hotta H, Adachi K, Ross AH, Jambrosic J, Koprowski H (1990) In vitro properties of human melanoma cells metastatic in nude mice. Cancer Res 50:2296-2302
17. Herlyn M, Herlyn D, Elder DE, Bondi E, Larossa D, Hamilton R, Sears HF, Balaban G, Guerry D, Clark WH, Koprowski H (1983) Phenotypic characteristics of cells derived from precursors of human malignant melanoma. Cancer Res 43:5502-5502
18. Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML, Merino MJ (1995) Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 147:33-41
19. Itoh K, Konishi A, Nomura S, Mizuno N, Nakamura Y, Sugimoto T (1979) Application of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt-glucose oxidase method. Brain Res 175:341-346
20. Kath R, Jambrosic JA, Holland L, Rodeck U, Herlyn M (1991) Tumor progression in melanoma: Development of invasive and growth factor-independent cell variants from primary melanomas. Cancer Res 51:2205-2211
21. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362:841-844
22. Kralli A, Ge R, Graeven U, Ricciardi RP, Weinmann R (1992) Negative regulation of the major histocompatibility complex class I enhancer in adenovirus type 12 transformed cells via a retinoic acid response element. J Virol 66:6979-6988
23. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309
24. Liu B, Earl HM, Baban D, Shoaibi M, Fabra A, Kerr DJ, Seymour LW (1995) Melanoma cell lines express VEGF Receptor KDR and respond to exogenously added VEGF. Biochem Biophys Res Commun 217:721-727
25. Mancianti ML, Herlyn M, Weil D, Jambrosic J, Rodeck U, Becker D, Diamond L, Clark WH, Koprowski H (1988) Phenotypic characteristics of cultured human nevus cells. J Invest Dermatol 90:134-141
26. Melber K, Zhu G, Diamond L (1989) SV-40-transfected human melanocyte sensitivity to growth inhibition by the phorbol-ester 12-O-tetradecanoyl-phorbol-13-acetate. Cancer Res 49:3650-3655
27. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-65
28. Pepper MS, Ferrara N, Orci L, Montesano R (1991) Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181:902-906
29. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K (1994) Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 269:6271-6274
30. Plate KH, Breier G, Weich HA, Risau W (1992) Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359:845-848
31. Poetgens A, Lubsen NH, Van Altena MC, Schoemakers JGG, Ruiter DJ, De Waal RM (1995) Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice. Am J Pathol 146:197-209
32. Poetgens AJ, Van Altena MC, Lubsen NH, Ruiter DJ, De Waal RM (1996) Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor. Am J Pathol 148:1203-1217
33. rffrt Rodeck U, Herlyn M, Menssen HD, Furlanetto RW, Koprowski H (1987) Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors. Int J Cancer 40:687-690
34. Rodeck U, Melber K, Kath R, Menssen H, Varello M, Atkinson B, Herlyn M (1991) Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. J Invest Dermatol 97:20-26
35. Rodeck U, Bossler A, Graeven U, Fox FE, Nowell PC, Kari C (1994) Transforming growth factor-β production and responsiveness in normal human melanocytes and melanoma cells. Cancer Res 54:515-581
36. Salven P, Heikkila P, Joensuu H (1997) Enhanced expression of vascular endothelial growth factor in metastatic melanoma. Br J Cancer 76:930-934
37. Schreiber AB, Winkler ME, Derynck R (1986) Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science 232:1250-1253
38. Srivastava A, Laidler P, Davies RP, Horgan K, Hughes LE (1988) The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. Am J Pathol 133:419-423
39. Termann BI, Dougher-Vermazen M, Carrion ME, Dimitrov DC, Armellino D, Gospodarowicz D, Bohlen P (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Commun 187:1579-1586
40. Van Belle P, Rodeck U, Nuamah I, Elder DE (1996) Melanoma-associated expression of TGF-β isoforms. Am J Pathol 148:1887-1894
41. Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324:1-9
42. Westermark B, Johnsson A, Paulsson Y, Betsholtz C, Heldin C-H, Herlyn M, Rodeck U, Koprowski H (1986) Human melanoma cells of primary and metastatic origin express the genes encoding the constituent chains of PDGF and produce a PDGF-like growth factor. Proc Natl Acad Sci USA 83:7197-7200
43. Zaborsky L, Leranth C (1985) Simultaneous ultrastructural demonstration of retrogradually transported horseradish peroxidase and choline acetyltransferase immunoreactivity. Histochemistry 82:529-537