Isolation and identification of the C6-hydroxy and C20-hydroxy metabolites and glucuronide conjugate of methylprednisolone by preparative high-performance liquid chromatography from urine of patients receiving high-dose pulse therapy

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 726, Issue 1-2, 1999, Pages 157-168

  Vree, T B ^a   Verwey Van Wissen, C P W G M ^a   Lagerwerf, A J ^a   Swolfs, A ^b   Maes, R A A ^c   Van Ooijen, R D ^c   Van Eikema Hommes, O R ^d   Jongen, P J H ^d  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d Multiple Sclerosis Centre Nijmegen   (Netherlands)

Author keywords

Methylprednisolone; Steroids

Indexed keywords

6BETA HYDROXY 6ALPHA METHYLPREDNISOLONE; 6BETA,20ALPHA DIHYDROXY 6ALPHA METHYLPREDNISOLONE; DRUG METABOLITE; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EXCRETION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STEREOISOMERISM; ULTRAVIOLET SPECTROPHOTOMETRY; METABOLISM; METHODOLOGY; SPECTROSCOPY; URINE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; METHYLPREDNISOLONE; MULTIPLE SCLEROSIS; SPECTRUM ANALYSIS;

EID: 0032586959     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00055-9     Document Type: Article

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