High-dose saquinavir plus ritonavir: Long-term efficacy in HIV-positive protease inhibitor-experienced patients and predictors of virologic response

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 22, Issue 2, 1999, Pages 132-138

  Paredes, R ^a   Puig, T ^a   Arno A ^a   Negredo, E ^a   Balague M ^a   Bonjoch, A ^a   Jou, A ^a   Tuldra A ^a   Tural, C ^a   Sirera, G ^a   Veny, A ^a   Romeu, J ^a   Ruiz, L ^a   Clotet, B ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Genotypic resistance; HAART; HIV 1 RNA; Protease inhibitors; Ritonavir; Salvage therapy; Saquinavir; SHAART

Indexed keywords

PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SALVAGE THERAPY; VIRUS INHIBITION; VIRUS LOAD;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032708315     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199910010-00004     Document Type: Article

References (15)

1. Li TS, Tubiana R, Katlama C, Calvez V, Ait Mohand H, Autran B. Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 1998;351:1682-6.
2. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-60.
3. Gulick RM, Mellors JW, Havlir D, et al., Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997;337:734-9.
4. Ferrando S, Van Gorp W, Mc Elhiney M, Goggin K, Sewell M, Rabkin J. Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function. AIDS 1998;12:F65-F70.
5. Fätkenheuer G, Theisen A, Rockstroh J, et al. Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients. AIDS 1997;11:F113-16.
6. Deeks SG, Grant RM, Beatty GW, Horton C, Detmer J, Eastman S. Activity of a ritonavir plus saquinavir-containing regimen in patients with virologic evidence of indinavir or ritonavir failure. AIDS 1998;12:F97-102.
7. Hirsch MS, Conway B, D'Aquila RT, et al. Antiretroviral drug resistance testing in adults with HIV infection. Implications for clinical management. JAMA 1998;279:1984-91.
8. Molla A, Korneyeva M, Gao Q, et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat Med 1996;2:760-6.
9. Merry C, Barry MG, Mulcahy F, et al. Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV infected patients. AIDS 1997;11:F29-33.
10. + T-cell counts in HIV-infected patients. Ann Intern Med 1996;124:1039-50.
11. Haas DW, Fessel WJ, Delaphena, et al. A Phase III, placebo-controlled, multicenter study to determine the effectiveness and tolerability of the combination of Efavirenz (EFV, SUSTIVA, DMP 266) versus indinavir in HIV-1 infected patients receiving nucleoside analogue (NRTI) Therapy at 36 weeks (DMP 266-020) [abstract I-244]. Program and abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, 1998.
12. Puig T, Bonjoch A, Ruiz, et al. Usefulness of ritonavir and saquinavir combination therapy for HIV-1 advanced patients failing on indinavir [abstract I-201]. Program and abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, 1997.
13. Kauffmann G,Duncombe C, Cunningham P, et al. Treatment response and durability of a double protease inhibitor therapy with saquinavir and ritonavir in an observational cohort of HIV-1-infected individuals. AIDS 1998;12:1625-30.
14. Tebas P, Patick AK, Kane EM, et al. Virologic responses to a ritonavir-saquinavir containing regimen in patients who had previously failed nelfinavir. AIDS 1999;13:F23-8.
15. Randomized trial comparing saquinavir soft gelatin capsules versus indinavir as part of triple therapy (CHEESE study). AIDS 1999; 13:F53-8.