Discovery of orally active nonpeptide bradykinin B2 receptor antagonists

Immunopharmacology

Volumn 43, Issue 2-3, 1999, Pages 163-168

  Asano, Masayuki ^a,b   Inamura, Noriaki ^b   Hatori, Chie ^b   Sawai, Hiroe ^b   Fujiwara, Tatsujiro ^b   Abe, Yoshito ^b   Kayakiri, Hiroshi ^b   Satoh, Shigeki ^b   Oku, Teruo ^b   Nakahara, Kunio ^b  

^a Med Chemistry Research Laboratories   (Japan)

^b Exploratory Research Laboratories   (Japan)

Author keywords

B2; Bradykinin; Orally active

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; 3 BROMO 8 [2,6 DICHLORO 3 [N [4 (N,N DIMETHYLCARBAMOYL)CINNAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLIMIDAZO[1,2 A]PYRIDINE; 8 [2,6 DICHLORO 3 [N [4 (N METHYLCARBAMOYL)CINNAMAMIDOACETYL] N METHYLAMINO]BENZYLOXY] 2 METHYLQUINOLINE; ANGIOTENSIN 1 RECEPTOR; BRADYKININ; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; CARRAGEENAN; CERULETIDE; ICATIBANT; KAOLIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BRONCHOSPASM; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; ILEUM CONTRACTION; INFLAMMATION; LUNG FIBROBLAST; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREATITIS; PAW EDEMA; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; UTERUS CONTRACTION;

ADMINISTRATION, ORAL; ANIMALS; HUMANS; INFLAMMATION; MICE; RATS; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ;

EID: 0032707709     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(99)00131-9     Document Type: Conference Paper

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