Candida infections in newborns: A review

Journal of Chemotherapy

Volumn 11, Issue 5, 1999, Pages 367-378

  Khoory, B J ^a   Vino, L ^b   Dall'agnola, A ^b   Fanos, V ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b NONE

Author keywords

Candidiasis; Fungal infection; Infant; Newborn; Sepsis

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; BIOZOLENE; FLUCONAZOLE; FLUCYTOSINE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; MICONAL; MICONAZOLE; NIZACOL; NYSTATIN; POLYENE; PYRIMIDINE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

BLOOD CULTURE; CANDIDIASIS; CENTRAL NERVOUS SYSTEM DISEASE; DRUG ABSORPTION; DRUG BINDING; DRUG CLEARANCE; DRUG INHIBITION; GASTROINTESTINAL SYMPTOM; HEMATOLOGIC DISEASE; HOSPITAL INFECTION; HUMAN; NEPHROTOXICITY; NEUROTOXICITY; NEWBORN; REVIEW; SEPSIS;

EID: 0032707308     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.1999.11.5.367     Document Type: Review

References (105)

1. Smith H, Congdon P. Neonatal systemic candidiasis. Arch Dis Child 1985; 60: 365-369.
2. Baley JE, Neonatal candidiasis: the currents challenge. Clin Perinatol 1991; 18 (2): 263-280.
3. Ng PC. Systemic fungal infections in neonates. Arch Dis Child 1994; 71: F130-F135.
4. Stoll BJ, Gordon T, Korones SB, et al. Late onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 1996; 129: 63-71.
5. Butler KM, Baker CJ. Candida: an increasingly important pathogen in the nursery. Pediatr Clin North Am 1988; 35: 543.
6. Pfaller M, Messer SA, Houston A, et al. National epidemiology of mycoses survey: a multicenter study of strain variation and antifungal susceptibility among isolates of Candida species. Diagn Microbiol Infect Dis 1998; 31 (1): 289-296.
7. Kossoff EH, Buescher ES, Karlowicz MG. Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases. Pediatr Infect Dis J 1998; 17 (6): 504-508.
8. Baley JE, Kliegeman RM, Boxerbaurn B, Fanaroff AA. Fungal colonization in the very low birth weight infants. Pediatrics 1986; 78: 225-232.
9. Weese-Mayer DE, Fondriest DW, Brouilette RT, et al. Risk factors associated with candidemia in the neonatal intensive care unit: a case-control study. Pediatr Infect Dis 1987; 6: 190-196.
10. Baley JE, Kliegman RM, Fanavoff AA. Disseminated fungal infections in very low-birth-weight infants: clinical manifestation and epidemiology. Pediatrics 1984; 73: 144-152.
11. Johnson DE, Thompson TR, Green TP, et al. Systemic candidiasis in very-low-birthweight infants (< 1500 grams). Pediatrics 1984; 73: 138-143.
12. Faix RG. Systemic Candida infections in intensive care nurseries: high incidence of central nervous system involvement. J Pediatr 1984; 105: 616-622.
13. Phillips G, Golledge C. Fungal infections in neonates. J Antimicrob Chemother 1991; 28: 159-161
14. Nicholls JM, Yuen KY, Tarn AY. Systemic fungal infections in neonates. Br J Hosp Med 1993; 49: 420-424.
15. Aujard Y. Fungal infections in neonates. J. Chemoth 1993; S1:482-486.
16. Faix RG. Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection. Pediatr Infect Dis J 1992; 11: 88-93.
17. Bennet JE. Mycoses. In: Mondell GI, Bennett JE, Dolin R Edt. Principles and practice of infections diseases, 4th Ed, New York: Churchill Livingstone, 1995: 2288-2306.
18. El Mohandes AE, Johnson-Bobbins L, Keiser JF, et al. Incidence of Candida parapsilosis colonization in an intensive care nursery population and its association with invasive fungal disease. Pediatr Infect Dis J 1994, 13: 520-524.
19. Noble WC, Sommerville DA. Microbiology of human skin. London: WB Saunders Co, 1974.
20. Seeling MS. The role of antibiotics in the pathogenesis of Candida infection. Am J Med 1966; 40: 887.
21. Kennedy MJ, Johnson AM, Volz PA et al. Virulence and adhesive properties of serotypes A and B of Candida albicans isolated from pediatric burn patients. J Med Microbiol 1992; 36: 428-436.
22. Betremieux P, Chevrier S, Quindos E, et al. Use of DNA fingerprinting and biotyping methods to study a Candida albicans outbreak in a neonate intensive care unit. Pediatr Infect Dis J 1994; 13: 899-905.
23. Sharp AM, Odds FC, Evans EVG. Candida strains from neonates in a special care baby unit. Arch Dis Child 1992; 67: 48.
24. Deventer AJM, Goessens WHF, Belkum A, et al. Improved detection of Candida albicans by PCR in blood of neutropenic mice with systemic candidiasis. J Clin Microbiol 1995; 33 (5), 625-628.
25. Miller MJ. Fungal infections. In: Remington JS, Klein JO, Edt. Infectious disease of the fetus, newborn and infant. Philadelphia: WB Saunders, 4th Ed, 1995: 704-736.
26. Baud O, Boithias C, Lacze-Hasmonteil T, et al. Maternofetal disseminated candidiasis and high-grade prematurity (French). Arch Pediatr 1997; 4: 331-334.
27. Blanc WA. Pathways of fetal and early neonatal infection. J Pediatr 1961; 59: 473-477.
28. Berry DL, Olson GL, Wen TS, et al. Candida chorioamnionitis: a report of two cases. J MaternFetal Med 1997; 6 (3), 151-154.
29. Shirar A, Rendu C, Vielh JP, et al. Congenital mycosis (Candida albicans). Biol Neonate 1974; 24: 273-288
30. Schwartz DA, Reef S. Candida albicans placentitis and funisitis: early diagnosis of congenital candidemia by histopathological examination of umbilical vessels. Pediatr Infect Dis J 1990; 9: 661-665.
31. Whyte RK, Hussainz D, Dela D. Antenatal infections with Candida species. Arch Dis Child 1982; 57: 528-535.
32. Kozinn PJ, Taschdjian CL, Wiener H. Incidence and pathogenesis of neonatal candidiasis. Clin North Am 1958; 5: 803-805.
33. Buff SJ, Mc Leinand R, Galles H et al. Candida albicans pneumonia. Radiographic appearance. Am J Radiol 1982; 138: 645-648.
34. Cosgrove BF, Reeves K, Mullins D, et al. Congenital cutaneous candidiasis associated with respiratory distress and elevation of liver function tests: a case report and review of literature. J Am Acad Dermatol 1997; 37: 817-823.
35. Butler KM, Rench MA, Baker CJ. Amphotericin B as a single agent in the treatment of systemic candidiasis in neonates. Pediatr Infect Dis J 1990; 9: 51-56.
36. Padovani EM, Khoory BJ, Dall' Agnola A, et al. Sepsis caused by Candida in the neonatal period. Pediatr Med Chir 1997; 19: 83-88.
37. Reef SE, Lasker BA, Butcher DS, et al. Nonperinatal nosocomial transmission of Candida albicans in a neonatal intensive care unit: prospective study. J Clin Microbiol 1998; 36 (5): 1225-1259.
38. Bourne HR, Lehrer RI, Cline MJ. 3′-5′cyclic adenosine monophosphate in the human leucocyte: synthesis, degradation, and effects on neutrophil candidacidal activity. J Clin Invest 1971; 50: 920-929.
39. Ng PC, Thomson MA, Dear PRF. Dexamethasone and infection in preterm babies: a controlled study. Arch Dis Child 1990; 65: 54-58.
40. Rabalais GP, Samiec TD, Bryant KK, et al. Invasive candidiasis in infants weighing more than 2500 grams at birth admitted to a neonatal intensive care unit. Pediatr Infect Dis J 1996; 15: 348-352.
41. Macdonald L, Baker C, Chenoweth C. Risk factors for candidemia in a children's hospital. Clin Infect Dis 1998; 26 (3): 642-645.
42. Mullet MD, Cook EF, Gallagher R, Nosocomial sepsis in the neonatal intensive care unit. J Perinatol 1998; 18 (2): 112-115.
43. Smith SD, Tagge EP, Miller J, et al. The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis. J Pediatr Surg 1990; 10: 1030-1034.
44. Odds FC, Candida and candidiasis, Baltimore University Park Press 1979.
45. Bale JF, Murph JR. Infections of the central nervous system in the newborn. Clin Perinatol 1997; 24 (4): 787-807.
46. Bennet R, Erikson M, Zetterström R. Increasing incidence of neonatal septicemia: causative organism and predisposing risk factors. Acta Pediatr Scand 1981, 70: 207-210.
47. Chesney PJ, Justman RA, Bogdamovicz WM. Candida meningitis in newborn infants: a review and report of combined amphotericin B flucocytosine therapy. John Hopkins Med J 1978; 142: 155-160.
48. Parker JC, McCloskey JI, Lee RS. The emergence of candidiasis; the dominant postmortem cerebral micosis. Am J Clin Pathol 1978; 70: 31-36.
49. Salaki JS, Louria DP, Chinal H. Fungal and yeast infections of the central nervous system. A clinical review. Medicine 1984; 63: 108-132.
50. Kozinn PJ, Taschdjian CL, Pishvasaden P et al. Candida meningitis successfully treated with amphotericin B. N Engl J Med 1963; 268: 881-884.
51. Incasu L, Akan H, Arslan A. Neonatal cerebral candidiasis: CT findings and clinical correlation. J Belge Radiol 1994; 77 (6): 278-279.
52. Lilieu LD, Ramamurthy RS, Pildes RS. Candida albicans meningitis in a premature neonate successfully treated with 5fluorocytosine and amphotericin B: A case report and review of the literature. Pediatrics 1978; 61: 57-61.
53. Polak A. Combination therapy with antifungal drugs. Mycoses 1988; 31 (52): 45-53.
54. Byers M, Champman S, Feldman S, et al. Fluconazole pharmacokinetics in the cerebrospinal fluid of a child with candida meningitis. Pediatr Infect Dis J 1992; 11: 895-896.
55. Weist DB, Fowler SL, Garner SS, et al. Fluconazole in neonatal disseminated candidiasis. Arch Dis Child 1991; 66: 1002-1006.
56. Scalarone GM, Mikami Y, Kurita N, et al. In vitro evaluations of the postantifungal effect: synergistic interaction between flucytosine and fluconazole against Candida albicans. Mycoses 1991; 34: 405-410.
57. Epelbaum S, Laurent C, Morin G, et al. Failure of fluconazole treatment in Candida meningitis. J Pediatr 1993; 123: 168-169.
58. Stuck KJ, Silver TM, Jaffe MH, et al. Sonographic demonstration of renal fungus balls. Radiology 1981; 142: 473-474.
59. Tomashefski JF, Abramowsky CR. Candida-associated renal papillary necrosis. Am J Clin Pathol 1981; 75: 190-194.
60. Heckmatt KA, Meadow SR, Anderson CK. Acute anuric renal failure in an infant with systemic candidiasis. Arch Dis Child 1979; 54: 70-72.
61. Bergman KA, Meis JF, Horrevorts AM, et al. Acute renal failure in a neonate due to pelviureteric candidal bezoars successfully treated with long-term systemic fluconazole. Acta Pediatr 1992; 81: 709-711.
62. Hitchcock RTJ, Pallett A, Hall MA, et al. Urinary tract candidiasis in neonates and infants. J Urology 1995; 76: 252-256.
63. Rehan VK, Davidson DC. Neonatal renal candidal bezoar. Arch Dis Child 1992; 67: 63-64.
64. Wise GP, Wainstein S, Goldberg GP, et al. Candida cystitis. Management by continuous bladder irrigation with amphotericin B. JAMA 1973; 224: 1636.
65. Baetz Greenwalt B, Debax B, Kumar ML. Bladder fungus ball: a reversible cause of neonatal obstructive uropathy. Pediatrics 1998; 81: 826-829.
66. Bartone FF, Hurwitz RS, Rojas EL, et al. The role of percutaneous nephrostomy in the management of obstructive candidiasis of the urinary tract in infants. J Urol 1988; 140: 338-341.
67. Weintrub PS, Chapman A, Piecuch R. Renal fungus ball in premature infant successfully treated with fluconazole. Pediatr Infect Dis J 1994; 13: 1152-1154.
68. Brammer KW, Farrow PR, Faulkner JW. Pharmacokinetics and tissue penetration of fluconazole in humans. Rev Infect Dis 1990; 12: 318-326.
69. Fishman LS, Griffin JR, Sapico FL, et al. Hematogenous Candida endophthalmitis - a complication of candidemia. N Engl J Med 1972; 286: 675-676.
70. Baley JE, Annable WL, Kliegman RM. Candida endophthalmitis in the premature infant. J Pediatr 1981; 98: 458-461.
71. Edwards JE, Foods RY, Montgomerie JZ, et al. Ocular manifestation of Candida septicemia: Review of seventy-six cases of hematogenous candida endophthalmitis. Medicine 1974; 53: 47-51.
72. Palmer EA. Endogenous Candida endophthalmitis in infants. Am J Ophtalmol 1980; 89: 388-392.
73. Hill HR, Mitchell TG, Matsen JM, et al. Recovery from disseminated candidiasis in a premature neonate. Pediatrics 1974; 53: 748-752.
74. Michelson PE, Rupp R, Efthimiadis B, Endogenous Candida endophthalmitis leading to bilateral corneal perforation. Am J Ophthalmol 1975; 80: 800-806.
75. Sanchez PJ, Siegel JD, Fishbein J. Candida endocarditis: successful medical management in three preterm infants and review of literature. Pediatr J Infect Dis 1991; 10 (3), 239-243.
76. Mayayo E, Moralejo J, Camps J, et al. Fungal endocarditis in premature infants: case report and review. Clin Infect Dis 1996; 22 (2): 366-368.
77. Michielutti F, Khoory BJ, Chiaffoni GP, et al. Fungal endocarditis, intracardiac and aortic thrombosis in neonate: report of two cases. J Ped (in press).
78. Foker JE, Bass JI, Thompson T, et al. Management of intracardiac fungal mass in premature infants. J Thorac Cardiovasc Surg 1984; 87: 244-250.
79. Hughes WT. Sytemic candidiasis; a study of 109 fatal cases. Pediatr J Infect Dis 1982; 1: 11-18.
80. Marsh D, Wilkerson SA, Cook SA, et al. Right atrial thrombosis formation: screening using two-dimensional echocardiograms in neonates with central venous catheters. Pediatrics 1988; 81: 284-286.
81. Alkalay AI, Mazkereth R, Santulli T, et al. Central venous line thrombosis in premature infants; a case management and literature review. Am J Perinatol 1993; 10: 323-326.
82. Girsoni ER, Mahata SK, Connors AF. Thrombosis and infection complicating central venous catheterization in neonates. J Pediatr Surg 1986; 9: 772-776.
83. Mokrohisky ST, Levine RL, Blumhagen JD, et al. Low positioning of umbilical artery catheters increase associated complications in newborn infants. N Engl J Med 1978; 299: 561.
84. Griffin JH. The contact phase of blood coagulation. Edinburgh: Churchill and Livingstone 1987: 101-115.
85. Peters M, Ten Cate JW, Koo LH. Persistent antithrom bin 3 deficiency: Risk factor for thromboembolic complications in neonates small for gestational age. J Pediatr 1984; 105: 310-314.
86. Ekelund H, Hender U, Nisson IM. Fibrinolysis in newborns. Acta Pediatr Scand 1970; 58: 33-43.
87. Özkutlu S, Özbarlas N, Özme S, et al. Intracardiac thrombosis diagnosed by echocardiography in childhood: predisposing and etiological factors. Int J Cardiol 1993; 40 (39): 251-256.
88. Delaplane D, Scott JP, Rigs TW, et al. Urokinase therapy for a catheter-related right atrial thrombus. J Pediatr 1982; 100: 149-152.
89. Mahony L, Snider AR, Silverman NH. Echocardiographic diagnosis of intracardiac thrombi complicating total parenteral nutrition. J Pediatr 1981; 98: 469-471.
90. Mendoza GJ, Soto A, Brown EG, et al. Intracardiac thrombi complicating central total parenteral nutrition: resolution without surgery or thrombolysis. J Pediatr 1986; 108: 610-613.
91. Kennedy LA, Drummond WH, Knight ME, et al. Successful treatment of neonatal aortic thrombosis with tissue plasminogen activator. J Pediatr 1990; 116: 798-801.
92. Keller MA, Sellers BB, Melish ME, et al. Systemic candidiasis in infants: a case presentation and literature review. Am J Dis Child 1977; 131: 1260-1263.
93. Gerberding KM, Eisenhut CC, Engle WA, et al. Congenital candida pneumonia and sepsis; a case report and a review of the literature. J Perinatol 1989; 9 (2): 159-161.
94. Swanson H. Hughes PA, Messer SA, et al. Candida albicans arthritis one year after successful treatment of fungemia in a healthy infant. J Pediatr 1996; 129 (5): 688-694.
95. Padovani EM, Chiaffoni GP, Fanos V, Khoory BJ et al. A case of Candida albicans arthritis in preterm infants (in Italian). Neonatologica 1998; 12 (1): 31-35.
96. Merchant RH, Sanghui KP, Sridar N, et al. Nursery outbreak of neonatal fungal arthritis treated with fluconazole. J Trop Pediatr 1997; 43 (2): 106-108.
97. Wainer S, Cooper PA, Funk E, et al. Prophylactic miconazole oral gel for the prevention of neonatal fungal rectal colonization and systemic infection. Pediatr Infect Dis 1992; 11: 713-716.
98. Burnie JP, Lee W, Williams JD, et al. Control of an outbreak of systemic Candida albicans. BMJ 1985; 291: 1012-1013.
99. Dato VM, Dajani AS. Candidemia in children with central venous catheter, role of catheter removal and amphotericin therapy. Pediatr Infect Dis J 1990; 9 (5): 309-314.
100. Baley JE, Kliegman RM, Fanaroff AA. Disseminated fungal infections in very low birth weight infants: therapeutic toxicity. Pediatrics 1984; 73: 153-157.
101. Baley JE, Meyers C, Kliegman RM, et al. Pharmacokinetic outcome of treatment and toxic effects of amphotericin B and 5 fluorocytosine in neonates. J Pediatr 1990; 116: 791-797
102. Lackner H, Schwinger W, Urban C, et al. Liposomial amphotericin-B (Ambisome) for treatment of disseminated fungal infections in two infants of very low birth weight. Pediatrics 1992; 89: 1259-1261.
103. Weitkamp JH, Poets CF, Sievers A, et al. Candida infections in very low birth weight infants: outcome and nephrotoxicity of treatment with liposomial amphotericin B (ambisome). Infection 1998; 26 (1): 11-15.
104. Bodé S, Pedersen-Bjegard C, Hjelt K. Candida albicans septicemia in a premature infant successfully treated with oral fluconazole. Scand J Infect Dis, 1992; 24: 673-675.
105. Saxe'n H, Hoppu K, Pohjavuori M. Pharmacokinetics of fluconazole in very low birth weight infants during first two weeks of life. Clin Pharmacol Ther 1993; 54: 269-277.