Candidemia in a neonatal intensive care unit: Trends during fifteen years and clinical features of 111 cases

Pediatric Infectious Disease Journal

Volumn 17, Issue 6, 1998, Pages 504-508

  Kossoff, Eric H ^a   Buescher, E Stephen ^a   Karlowicz, M Gary ^a,b  

^a CHILDREN S HOSPITAL OF THE KING S DAUGHTERS   (United States)

^b NONE   (United States)

Author keywords

Candida; Candidemia; Neonatal intensive care unit; Neonate; Nosocomial

Indexed keywords

ARTICLE; BLOOD CULTURE; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CANDIDIASIS; FUNGUS CULTURE; HOSPITAL INFECTION; HUMAN; INFANT; INFECTION RATE; MAJOR CLINICAL STUDY; MORTALITY; NEWBORN INTENSIVE CARE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR;

CANDIDA ALBICANS; CANDIDIASIS; FUNGEMIA; HUMANS; INCIDENCE; INFANT MORTALITY; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTENSIVE CARE UNITS, NEONATAL; PREVALENCE; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC;

EID: 0031806265     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199806000-00014     Document Type: Article

References (25)

1. Fraser VJ, Jones M, Dunkel J, Storfer S, Medoff G, Dunagan WG. Candidemia in a tertiary care hospital: epidemiology, risk factors and predictors of mortality. Clin Infect Dis 1992;15:414-21.
2. Stamos JK, Rowley AH. Candidemia in a pediatric population. Clin Infect Dis 1995;20:571-5.
3. Butler KM, Baker CJ. Candida: an increasingly important pathogen in the nursery. Pediatr Clin North Am 1988;35: 543-63.
4. Baley JE. Neonatal candidiasis: the current challenge. Clin Perinatol 1991;18:263-80.
5. Stoll BJ, Gordon T, Korones SB, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 1996;129:63-71.
6. Leibovitz E, Iuster-Reicher A, Amitai M, Mogilner B. Systemic candidal infections associated with the use of peripheral venous catheters in neonates: a 9-year experience. Clin Infect Dis 1992;14:485-91.
7. Donowitz LG, Hendley JO. Short-course amphotericin B therapy for candidemia in pediatric patients. Pediatrics 1995; 95:888-91.
8. Glick C, Graves GR, Feldman S. Neonatal fungemia and amphotericin B. South Med J 1993;86:1368-71.
9. Ashkenazi S, Leibovici L, Samra Z, Konisberger H, Drucker M. Risk factors for mortality due to bacteremia and fungemia in childhood. Clin Infect Dis 1992;14:949-51.
10. Xanthou M, Valassi-Adam E, Kintzonidou E, Matsaniotis N. Phagocytosis and killing ability of Candida albicans by blood leukocytes of healthy term and preterm babies. Arch Dis Child 1975;50:72-5.
11. Baley JE, Kliegman RM, Boxerbaum B, Fanaroff AA. Fungal colonization in the very low birth weight infant. Pediatrics 1986;78:225-32.
12. Rowen JL, Atkins JT, Levy ML, Baer SC, Baker CJ. Invasive fungal dermatitis in the <1000 gram neonate. Pediatrics 1995;95:682-7.
13. Karlowicz MG. Risk factors associated with fungal peritonitis in very low birth weight neonates with severe necrotizing enterocolitis: a case control study. Pediatr Infect Dis J 1993; 12:574-7.
14. Faix RG, Kovanik SM, Shaw TR, Johnson RV. Mucocutaneous and invasive candidiasis among very low birth weight (<1500 grams) infants in intensive care nurseries: a prospective study. Pediatrics 1989;83:101-7.
15. Botas CM, Kurlat I, Young SM, Sola A. Disseminated candidal infections and intravenous hydrocortisone in preterm infants. Pediatrics 1995;95:883-7.
16. Horbar, JD, Wright, EC, Onstad, L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. Pediatrics 1993;92:191-6.
17. Waggoner-Fountain LA, Walker MW, et al. Vertical and horizontal transmission of unique Candida species to premature newborns. Clin Infect Dis 1996;22:803-8.
18. Strausbaugh LJ, Sewell DL, Ward TT, Pfaller MA, Heitzman T, Tjoelker R. High frequency of yeast carriage on hands of hospital personnel. J Clin Microbiol 1994;32:2299-300.
19. Brown J, Froese-Fretz A, Luckey D, Todd JK. High rate of hand contamination and low rate of hand-washing before infant contact in a neonatal intensive care unit. Pediatr Infect Dis J 1996;15:908-10.
20. Faix RG. Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection. Pediatr Infect Dis J 1992;11: 88-93.
21. Butler KM, Rench MA, Baker CJ. Amphotericin B as a single agent in the treatment of systemic candidiasis in neonates. Pediatr Infect Dis J 1990;9:51-6.
22. Saxen HS, Virtanen M, Carlson P, et. al. Neonatal Candida parapsilosis outbreak with a high case fatality rate. Pediatr Infect Dis J 1995;14:776-81.
23. Weems JJ. Candida parapsilosis: epidemiology, pathogenicity, clinical manifestations, and antimicrobial susceptibility. Clin Infect Dis 1992;14:756-66.
24. Goldstein E, Grieco MH, Finkel G, Louria DB. Studies on the pathogenesis of experimental Candida parapsilosis and Candida guilliermondii infections in mice. J Infect Dis 1965;115: 293-302.
25. Jafari HS, Saez-Llorens X, Grimpel E, Argyle JC, Olsen KD, McCracken GH Jr. Characteristics of experimental Candida albicans infection of the central nervous system in rabbits. J Infect Dis 1991;164:389-95.