Serotonin and the prediction of response time to fluoxetine in patients with mild depression

Psychiatry Research

Volumn 88, Issue 2, 1999, Pages 89-93

  New, Antonia S ^a   Woo Ming, Ann ^a   Mitropoulou, Vivian ^a   Silverman, Jeremy ^a   Reynolds, Diedre ^a   Schopick, Frances ^a   Trestman, Robert L ^a   Siever, Larry J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Fenfluramine; Hamilton Depression Rating Scale; Prolactin

Indexed keywords

FENFLURAMINE; PLACEBO; PROLACTIN; SEROTONIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; FENFLURAMINE; FLUOXETINE; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; PROLACTIN; REMISSION INDUCTION; SEROTONIN; SEROTONIN AGENTS; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0032706755     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(99)00057-8     Document Type: Article

References (16)

1. Cleare A.J., Murray R.M., O'Keane V. Assessment of serotonergic function in major depression using D-fenfluramine: relation to clinical variables and antidepressant response. Biological Psychiatry. 44(7):1998;555-561.
2. Coccaro E.F., Siever L.J., Klar H.M., Maurer G., Cochrane K., Cooper T.B., Mohs R.C., Davis K.L. Serotonergic studies in patients with affective and personality disorders. Archives of General Psychiatry. 46:1989;587-599.
3. Fava M., Uebelacker L.A., Alpert J.E., Nierenberg A.A., Pava J.A., Rosenbaum J.F. Major depressive subtypes and treatment response. Biological Psychiatry. 42(7):1997;568-576.
4. Kavoussi R.J., Hauger R.L., Coccaro E.F. Prolactin response to D-fenfluramine in major depression before and after treatment with serotoni re-uptake inhibitors. Biological Psychiatry. 45(3):1999;295-299.
5. Leatherman M.E., Ekstrom R.D., Corrigan M., Carson S.W., Mason G., Golden R.N. Central serotonergic changes following antidepressant treatment: a neuroendocrine assessment. Psychopharacology Bulletin. 29(2):1993;149-154.
6. Lopez-Ibor J.J., Saiz-Ruiz J., Iglesias L.M. The fenfluramine challenge test in the affective spectrum: a possible marker of endogeneity and severity. Pharmacopsychiatry. 21(1):1988;9-14.
7. Malone K.M., Thase M.E., Mieczkowski T., Myers J.E., Stull S.D., Cooper T.B., Mann J.J. Fenfluramine challenge test as a predictor of outcome in major depression. Psychopharmacology Bulletin. 29(2):1993;155-161.
8. Mann J.J., McBride P.A., Malone K.M., DeMeo M., Keilp J. Blunted serotonergic responsivity in depressed inpatients. Neuropsychopharmacology. 13(1):1995;53-64.
9. Mann J.J., Malone K.M. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed patients. Biological Psychiatry. 41(2):1997;162-171.
10. Mitchell P., Smythe G. Hormonal responses to fenfluramine in depressed and control subjects. Journal of Affective Disorders. 19(1):1990;43-51.
11. O'Keane V., McLoughlin D., Dinan T.G. D-Fenfluramine-induced prolactin and cortisol release in major depression: response to treatment. Journal of Affective Disorders. 26(3):1992;143-150.
12. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clinical Chemistry. 40(2):1994;288-295.
13. Park S.B., Williamson D.J., Cowen P.J. Do the endocrine and subjective effects of D-fenfluramine predict response to selective serotonin re-uptake inhibitors? International Clinical Psychopharmacology. 10(4):1995;215-220.
14. Sheline Y., Bardgett M.E., Csernansky J.G. Correlated reductions in cerebrospinal fluid 5-HIAA and MHPG concentrations after treatment with selective serotonin re-uptake inhibitors. Journal of Clinical Psychopharmacology. 17(1):1997;11-14.
15. Siever, L.J., Coccaro, E.F., Benjamin, E., Rubinstein, K., Davis, K.L., 1986. Adrenergic and serotonergic receptor responsiveness in depression. In: Porter, R., Bock, G., Clark, S. (Eds.), Antidepressants and Receptor Function, Symposium 123. CIBA Foundation, pp. 148-169.
16. Spitzer, R.L., Endicott, J., 1978. Schedule for Affective Disorders and Schizophrenia (SADS). New York State Psychiatric Institute, Biometrics Research, New York.