Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis 1 (NF1) gene

Neuroscience Letters

Volumn 211, Issue 2, 1996, Pages 85-88

  Geist, Robert T ^a   Gutmann, David H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Central nervous system; Isoform; Learning disabilities; Neurofibromatosis 1 (NF1) gene; Neurons; Tumor suppressor gene

Indexed keywords

CYCLOPHILIN; NEUROFIBROMIN;

ADOLESCENT; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; EMBRYO; EXON; FOREBRAIN; GENE EXPRESSION; LEARNING DISORDER; MOUSE; NERVE CELL DIFFERENTIATION; NEUROFIBROMATOSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; SPINAL CORD; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE;

EID: 0030596546     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12730-0     Document Type: Article

References (17)

1. [1] Gutmann, D.H., The neurofibromatoses: new insights into old problems, Curr. Opin. Neurol., 7 (1994) 166-171.
2. [2] Basu, T.N., Gutmann, D.H., Fletcher, J.A., Glover, T.W., Collins, F.S. and Downward, J., Aberrant regulation of ras proteins in tumour cells from type 1 neurofibromatosis patients. Nature, 356 (1992) 713-715.
3. ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis, Cell, 69 (1992) 265-273.
4. [4] Andersen, L.B., Fountain, J.W., Gutmann, D.H., Tarle, S.A., Glover, T.W., Dracopoli, N.C., Housman, D.E. and Collins, F.S., Mutations in the neurofibromatosis 1 gene in sporadic malignant melanomas, Nature Genet., 3 (1993) 118-121.
5. [5] Johnson, M.R., Look, A.T., DeClue, J.E., Valentine, M.B. and Lowy, D.R., Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP-Ras, Proc. Natl. Acad. Sci. USA, 90 (1993) 5539-5543.
6. [6] The, I., Murthy, A.E., Hannigan, G.E., Jacoby, L.B., Menon, A.G., Gusella, J.F. and Bernards, A., Neurofibromatosis type 1 gene mutations in neuroblastoma, Nature Genet., 3 (1993) 62-66.
7. [7] Johnson, M.R., DeClue, J.E., Felzmann, S., Vass, W.C., Xu, G., White, R. and Lowy, D., Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function, Mol. Cell. Biol. 14 (1994) 641-645.
8. [8] North, K., Joy. P., Yuille, D., Cocks, N. and Hutchins, P., Cognitive function and academic performance in children with neurofibromatosis type 1, Dev. Med. Child Neurol., 37 (1995) 427-436.
9. [9] Viskochil, D., Buchberg, A.M., Xu, G., Cawthon, R.M., Stevens, J., Wolff, R.K., Culver, M., Carey, J.C., Copeland, N.G., Jenkins, N.A., White, R. and O'Connell, P., Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus, Cell, 62 (1990) 187-192.
10. [10] Marchuk, D.A., Saulino, A.M., Tavakkol, R., Swaroop, M., Wallace, M.R., Andersen, L.B., Mitchell, A.L., Gutmann, D.H., Boguski, M. and Collins, F.S., cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product, Genomics, 11 (1991) 931-940.
11. [11] Gutmann, D.H., Geist, R.T., Wright, D.E. and Snider, W.D., Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues, Cell Growth Differ., 6 (1995) 315-322.
12. [12] Gutmann, D.H., Geist, R.T., Rose, K. and Wright, D.E., Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues, Dev. Dynam., 202 (1995) 302-311.
13. [13] Danglot, G., Regnier, V., Fauvet, D., Vassal, G., Kujas, M. and Bernheim, A., Neurofibromatosis 1 (NF1) mRNAs expressed in the central nervous system are differentially spliced in the 5′ part of the gene, Hum. Mol. Genet., 4 (1995) 915-920.
14. [14] Daston, M.M., Scrable, H., Nordlund, M., Sturbaum, A.K., Nissen, L.M. and Ratner, N., The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells and oligodendrocytes, Neuron, 8 (1992) 415-428.
15. [15] Hewett, S.J., Csernansky, C.A. and Choi, D.W., Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS, Neuron, 13 (1994) 487-494.
16. [16] Dugan, L.L., Bruno, V.M.G., Amagasu, S.M. and Giffard, R.G., Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity, J. Neurosci., 15 (1995) 4545-4555.
17. [17] Daston, M.M. and Ratner, N., Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development, Dev. Dynam., 195 (1993) 216-226.