Long-lasting remission and successful treatment of acquired factor VIII inhibitors using cyclophosphamide in a patient with systemic lupus erythematosus

Rheumatology

Volumn 38, Issue 10, 1999, Pages 1007-1009

  Trotta, F ^a   Bajocchi, G ^a,d   La Corte, R ^a   Moratelli, S ^b   Sun, L Y ^c  

^a Division of Rheumatology   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^d UNIVERSITY HOSPITAL OF FERRARA   (Italy)

Author keywords

Acquired deficiency; Cyclophosphamide; Factor VIII; Metrorrhagia; Systemic lupus erythematosus; Treatment

Indexed keywords

AUTOANTIBODY; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 8 INHIBITOR; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; LUPUS ANTICOAGULANT; PREDNISOLONE;

ADULT; ARTICLE; BLEEDING TENDENCY; BLOOD CLOTTING TEST; CASE REPORT; ECCHYMOSIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; METRORRHAGIA; ORAL DRUG ADMINISTRATION; PARTIAL THROMBOPLASTIN TIME; PLASMAPHERESIS; PRIORITY JOURNAL; REMISSION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADMINISTRATION, ORAL; ADULT; CYCLOPHOSPHAMIDE; FACTOR VIII; FEMALE; HEMOPHILIA A; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; METRORRHAGIA; PULSE THERAPY, DRUG; REMISSION INDUCTION;

EID: 0032701833     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/38.10.1007     Document Type: Article

References (14)

1. Aledort L. Inhibitors in hemophilia patients: current status and management. Am J Hematol 1994;47:208-17.
2. Green D, Lechner K. A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemostasis 1981;45:200-3.
3. Algiman M, Dietrich G, Nydegger UE, Boieldieu D, Sultan Y, Kazatchkine MD. Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals. Proc Natl Acad Sci USA 1992;89:3795-9.
4. Ballard HS, Nyamuswa G. Life threatening haemorrhage in a patient with rheumatoid arthritis and a lupus anticoagulant coexisting with acquired autoantibodies against factor VIII. Br J Rheumatol 1993;32:515-7.
5. Grossman R, Wankmuller H, Schwender S, Kirschner J, Mansouri-Taleghani B, Keller P et al. The diagnosis and therapy of acquired factor-VIII inhibitors in combination with lupus anticoagulants. Dtsch Med Wochenschr 1996;12:906-10.
6. Lottenberg R, Kentro TB, Kitchens CS. Acquired hemophilia: A natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Arch Intern Med 1987;147:1077-81.
7. Pizzuto J, Ambriz R, De la Paz Reyna M, Monrroy LM, Morale MR, Aviles A et al. Acquired von Willebrand's syndrome during autoimmune disorder. Thromb Haemostasis 1980;29:1523-8.
8. Igarashi N, Miura M, Kato E, Matsuda T, Itoh K, Abildgaard CF et al. Acquired von Willebrand's Syndrome with lupus-like serology. Am J Pediatr Hematol Oncol 1989;11:32-5.
9. Pirner K, Rosier W, Kalden JR, Manger B. Long-term remission after i.v. immunoglobulin therapy in acquired antihemophilic factor hemophilia with systemic lupus erythematosus. Z Rheumatol 1990;49:378-81.
10. O'Connor CR, Reginato AJ, Ing JH, Keech JA. Prolonged activated partial thromboplastin time in systemic lupus erythematosus overlap syndrome: fatal bleeding due to factor VIII inhibitor. J Clin Rheum 1995;1:57-9.
11. Jackson N, Hashim ZA, Zainal NA, Jamaluddin N. Puerperal acquired factor VIII inhibitor causing a von Willebrand-like syndrome in a patient with anti-DNA antibodies. Sing Med J 1995;36:230-1.
12. Shulman S, Langevitz P, Livneh A, Marinowitz U, Seligsohn U, Varon D. Cyclosporin therapy for acquired factor VIII inhibitor in a patient with systemic lupus erythematosus. Thromb Haemostasis 1996;76:334-6.
13. Lafferty TE, Smith JB, Schuster SJ, De Horatius RJ. Treatment of acquired factor VIII inhibitor using intravenous immunoglobulin in two patients with systemic lupus erythematosus. Arthritis Rheum 1997;40:775-8.
14. Green D. The management of factor VIII inhibitors in non-hemophilic patients. Prog Clin Biol Res 1984;150:337-52.