Expression of the neurofibromatosis Type 2 gene in human tissues

Journal of Histochemistry and Cytochemistry

Volumn 47, Issue 11, 1999, Pages 1471-1479

  Den Bakker, Michael A ^a   Vissers, Kees J ^a   Molijn, Anco C ^a   Kros, Johan M ^a   Zwarthoff, Ellen C ^a   Van Der Kwast, Theo H ^a  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

Gene expression; Immunohistochemistry; Immunoprecipitation; In situ hybridization; Neurofibromatosis type 2

Indexed keywords

CYTOSKELETON PROTEIN; GENE PRODUCT;

ARTICLE; BRAIN ARACHNOID; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; MENINGIOMA; NEURILEMOMA; NEUROFIBROMATOSIS; PRIORITY JOURNAL; SCHWANN CELL; TUMOR SUPPRESSOR GENE;

ARACHNOIDEA;

EID: 0032699652     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549904701113     Document Type: Article

References (44)

1. Amieva MR, Furthmayr H (1995) Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. Exp Cell Res 219:180-196
2. Arakawa H, Hayashi N, Nagase H, Ogawa M, Nakamura Y (1994) Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancer. Hum Mol Genet 3:565-568
3. Arpin M, Algrain M, Louvard D (1994) Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1. Curr Opin Cell Biol 6:136-141
4. Bianchi AB, Hara T, Ramesh V, Gao J, Klein-Szanto AJP, Morin F, Menon AG, Trofatter JA, Gusella JG, Seizinger BR, Kley N (1994) Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tissue types. Nature Genet 6:185-192
5. Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Klein-Szanto AJ, Testa JR (1995) High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas [see comments]. Proc Natl Acad Sci USA 92:10854-10858
6. Claudio JO, Lutchman M, Rouleau GA (1995) Widespread but cell type-specific expression of the mouse neurofibromatosis type 2 gene. Neuroreport 6:1942-1946
7. Claudio JO, Marineau C, Rouleau GA (1994) The mouse homologue of the neurofibromatosis type 2 gene is highly conserved. Hum Mol Genet 3:185-190
8. Claudio JO, Veneziale RW, Menko AS, Rouleau GA (1997) Expression of schwannomin in lens and Schwann cells. Neuroreport 8:2025-2030
9. den Bakker MA, Riegman PHJ, Hekman RACP, Boersma W, Janssen P, van de Kwast T, Zwarthoff EC (1995a) The product of the NF2 tumour suppressor gene localizes near the plasma membrane and is highly expressed in muscle cells. Oncogene 10:757-763
10. den Bakker MA, Tascilar M, Riegman PHJ, Hekman ACP, Boersma W, Janssen PJA, de Jong TAW, Hendriks W, van der Kwast TH, Zwarthoff EC (1995b) Neurofibromatosis type 2 protein colocalizes with elements of the cytoskeleton. Am J Pathol 147: 1339-1349
11. Gonzalez-Agosti C, Xu L, Pinney D, Beauchamp R, Hobbs W, Gusella J, Ramesh V (1996) The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene 13:1239-1247
12. Graham MF, Diegelmann RF, Elson CO, Bitar KN, Ehrlich HP (1984) Isolation and culture of human intestinal smooth muscle cells. Proc Soc Exp Biol Med 176:503-507
13. Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, Rubenstein A, Viskochil D (1997) The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2 [see comments]. JAMA 278:51-57
14. Gutmann DH, Wright DE, Geist RT, Snider WD (1995) Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Hum Mol Genet 4:471-478
15. Haase V, Trofatter J, MacCollin M, Tarttelin E, Gusella J, Ramesh V (1994) The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms. Hum Mol Genet 3:407-411
16. Henry MD, Gonzalez-Agosti C, Solomon F (1995) Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy terminal domains. J Cell Biol 129:1007-1022
17. Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S, Tsukita S (1996) Regulation of ERM (ezrin, radixin, moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol 135:37-51
18. Hitotsumatsu T, Kitamoto T, Iwaki T, Fukui M, Tateishi J (1994) An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues. J Biochem 116:1205-1207
19. Huynh DP, Mautner V, Baser ME, Stavrou D, Pulst SM (1997) Immunohistochemical detection of schwannomin and neurofibromin in vestibular schwannomas, ependymomas and meningiomas. J Neuropathol Exp Neurol 56:382-390
20. Huynh DP, Nechiporuk T, Pulst SM (1994) Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol 161:538-551
21. Huynh DP, Pulst SM (1996) Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells. Oncogene 13:73-84
22. Huynh DP, Tran TM, Nechiporuk T, Pulst SM (1996) Expression of neurofibromatosis 2 transcript and gene product during mouse fetal development. Cell Growth Differ 7:1551-1561
23. Kleymenova EV, Bianchi AA, Kley N, Pylev LN, Walker CL (1997) Characterization of the rat neurofibromatosis 2 gene and its involvement in asbestos-induced mesothelioma. Mol Carcinogen 18:54-60
24. Lindenbergh-Kortleve DJ, Rosato RR, van Neck JW, Nauta J, van Kleffens M, Groffen C, Zwarthoff EC, Drop SLS (1997) Gene expression of the insulin-like growth factor system during mouse kidney development. Mol Cell Endocrinol 132:81-91
25. Mautner VF, Tatagiba M, Lindenau M, Funsterer C, Pulst SM, Kluwe L, Zanella FE (1995) Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity, and variety. AJR 165:951-955
26. + exchange, is a common interactor for merlin and ERM proteins. J Biol Chem 273:1273-1276
27. Rouleau GA, Merel P, Lutchman M, Sanson M, Zucman J, Marineau C, Hoang Xuan K, Demczuk S, Desmaze C, Plougastel B, Pulst SM, Lenoir G, Bijlsma E, Fashold R, Dumanski J, de Jong P, Parry D, Eldrige R, Aurias A, Delattre O, Thomas G (1993) Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2 [see comments]. Nature 363:515-521
28. Sainio M, Zhao F, Heiska L, Turunen O, den Bakker M, Zwarthoff E, Lutchman M, Rouleau G, Jaaskelainen J, Vaheri A, Carpen O (1997) Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J Cell Sci 110:2249-2260
29. Sainz J, Huynh DP, Figueroa K, Ragge NK, Baser ME, Pulst SM (1994) Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum Mol Genet 3:885-891
30. Sato N, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1992) A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J Cell Sci 103:131-143
31. Scherer SS, Gutmann DH (1996) Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells. J Neurosci Res 46:595-605
32. Schuller AGP, Zwarthoff EC, Drop SLS (1993) Gene expression of the six mouse insulin-like growth factor binding proteins. Mol Cell Endocrinology 132:2544-2550
33. Scoles DR, Huynh DP, Morcos PA, Coulsell ER, Robinson NG, Tamanoi F, Pulst SM (1998) Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nature Genet 18:354-359
34. Sekido Y, Pass HI, Bader S, Mew DJ, Christman MF, Gazdar AF, Minna JD (1995) Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res 55:1227-1231
35. Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L, Burwick JA, Beauchamp R, Pinney D, Louis DN, Ramesh V (1997a) Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system. J Neuropathol Exp Neurol 56:735-742
36. Stemmer-Rachamimov A, Xu L, Gonzalez-Agosti C, Burwick J, Pinney D, Beauchamp R, Jacoby L, Gusella J, Ramesh V, Louis D (1997b) Universal absence of merlin but not other ERM family members, in schwannomas. Am J Pathol 151:1649-1654
37. Takeshima H, Nishi T, Yamamoto K, Kino T, Nakamura H, Saya H, Kochi M, Kuratsu JI, Ushio Y (1998) Loss of merlin-p85 protein complex in NF2-related tumors. Int J Oncol 12:1073-1078
38. Takeuchi K, Sato N, Kasahara H, Funayama N, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1994) Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol 125:1371-1384
39. Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, Haasse VH, Ambrose CM, Munroe D, Bove C, Haines JL, Martuza RL, MacDonald ME, Seizinger BR, Short MP, Buckler AJ, Gusella JF (1993) A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72: 791-800
40. Tsukita S, Yonemura S, Tsukita S (1997) ERM proteins: head to tail regulation of actin-plasma membrane interaction. Trends Biol Sci 22:53-58
41. Vaheri A, Carpen O, Heiska L, Helander TS, Jaaskelainen J, Majander-Nordeswan P, Sainio M, Timonen T, Turunen O (1997) The ezrin protein familiy: membrane-cytoskeleton interactions and disease associations. Curr Opin Cell Biol 9:659-666
42. Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T (1994) Cooperative tumorigenic effects of germline mutations in Rb and p53. Nature Genet 7:480-484
43. Xu HM, Gutmann DH (1998) Merlin differentially associates with the microtubule and actin cytoskeleton. J Neurosci Res 51:403-415
44. Zwarthoff EC (1996) Neurofibromatosis and associated tumour suppressor genes. Pathol Res Pract 192:647-657