Detection of MUM1/IRF4-IgH fusion in multiple myeloma

Leukemia

Volumn 13, Issue 11, 1999, Pages 1812-1816

  Yoshida, S ^a   Nakazawa, N ^b   Iida, S ^a   Hayami, Y ^a   Sato, S ^a   Wakita, A ^a   Shimizu, S ^c   Taniwaki, M ^b   Ueda, R ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c SHIMANE PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

FISH; IgH insertion; Multiple myeloma; MUM1 IRF4; PFGE; t(6; 14)(p25; q32)

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; INTERFERON REGULATORY FACTOR 4; MESSENGER RNA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEVICE; DIAGNOSTIC PROCEDURE; DNA PROBE; ENHANCER REGION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE LOCUS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTERPHASE; MALE; MULTIPLE MYELOMA; MULTIPLE MYELOMA ONCOGENE 1; ONCOGENE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

EID: 0032697261     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401563     Document Type: Article

References (22)

1. Iida S, Dalla-Favera R. Molecular pathogenesis of multiple myeloma. Rev Clin Exp Hematol 1997; 3: 60-70.
2. Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998; 91: 3-21.
3. Bergsagel PL, Chesi M, Nardini E, Brents LA, Kirby SL, Kuehl WM. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci USA 1996; 93: 13931-13936.
4. Nishida K, Tamura A, Nakazawa N, Ueda Y, Abe T, Matsuda F, Kashima K, Taniwaki M. The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization. Blood 1997; 90: 526-534.
5. Chesi M, Bergsagel PL, Brents LA, Smith CM, Gerhard DS, Kuehl WM. Dysregulation of Cyclin D1 by translocations into an IgH gamma switch region in two multiple myeloma cell lines. Blood 1996; 88: 674-681.
6. Chesi M, Nardini E, Brents LA, Schrock E, Ried T, Kuehl WM, Bergsagel PL. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997; 16: 260-264.
7. Richelda R, Ronchetti D, Baldini L, Cro L, Viggiano L, Marzella R, Rocchi M, Otsuki T, Lombardi L, Maiolo AT, Neri A. A novel chromosomal translocation t(4;14)(p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Blood 1997; 90: 4062-4070.
8. Chesi M, Nardini E, Lim RSC, Smith KD, Kuehl WM, Bergsagel PL. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 1998; 92: 3025-3034.
9. Iida S, Rao PH, Butler M, Corradini P, Boccadoro M, Klein B, Chaganti RSK, Dalla-Favera R. Deregulation of the MUM1/IRF4 gene by chromosomal translocation in multiple myeloma. Nat Genet 1997; 17: 226-230.
10. Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM. Freguent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to Ig locus in multiple myeloma. Blood 1998; 91: 4457-4463.
11. Rao PH, Cigudosa JC, Ning Y, Calasanz MJ, Iida S, Tagawa S, Michaeli J, Klein B, Dalla-Favera R, Jhanswar SC, Ried T, Chaganti RSK. Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood 1998; 92: 1743-1748.
12. Mittrücker H-W, Matsuyama T, Grossman A, Kundig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997; 275: 540-543.
13. Yamagata T, Nishida J, Tanaka T, Sakai R, Mitani K, Yoshida M, Taniguchi T, Yazaki Y, Hirai H. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol Cell Biol 1996; 16: 1283-1294.
14. Seto M, Yamamoto K, Iida S, Akao Y, Utsumi KR, Kubonishi I, Miyoshi I, Ohtsuki T, Yawata Y, Namba M, Motokura T, Arnold A, Takahashi T, Ueda R. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene 1992; 7: 1401-1406.
15. Tagawa S, Doi S, Taniwaki M, Abe T, Kanayama Y, Nojima J, Matsubara K, Kitani T. Amylase-producing plasmacytoma lines, AD3 and FR4, with der(14)t(8;14) and dic(8)t(1;8) established from ascites. Leukemia 1990; 4: 600-605.
16. Zhang X-G, Gaillard JP, Robillard N, Lu Z-Y, Gu Z-J, Jourdan M, Boiron JM, Bataille R, Klein B. Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma. Blood 1994; 83: 3654-3663.
17. Iida S, Rao PH, Nallasivam P, Hibshoosh H, Butler M, Louie DC, Dyomin V, Ohno H, Chaganti RSK, Dalla-Favera R. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood 1996; 88: 4110-4117.
18. Taniwaki M, Nishida K, Ueda Y, Misawa S, Nagai M, Tagawa S, Yamagami T, Sugiyama H, Abe M, Fukuhara S, Kashima K. Interphase and metaphase detection of the breakpoint of 14q32 translocations in B-cell malignancies by double-colour fluorescence in situ hybridization. Blood 1995; 85: 3223-3228.
19. Madisen L, Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev 1994; 8: 2212-2226.
20. Neri A, Murphy JP, Cro L, Ferrero D, Tarella C, Baldini L, Dalla-Favera R. RAS oncogene mutation in multiple myeloma. J Exp Med 1989; 170: 1715-1725.
21. Corradini P, Inghirami G, Astolfi M, Ladetto M, Voena C, Ballerini P, Gu W, Nilsson K, Knowles DM, Boccadoro M, Pileri A, Dalla-Favera R. Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasia. Leukemia 1994; 8: 758-767.
22. Ng MHL, Chung YF, Lo KW, Wickham NWR, Lee JCK, Huang DP. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood 1997; 89: 2500-2506.