Body composition as a clinical endpoint in the treatment of growth hormone deficiency

Hormone Research

Volumn 51, Issue SUPPL. 3, 1999, Pages 132-140

  Haymond, Morey W ^a,b   Sunehag, Agneta L ^a   Ellis, Kenneth J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

Methods in measuring body composition; rhGH

Indexed keywords

FAT; HUMAN GROWTH HORMONE;

BODY COMPOSITION; BODY FAT; CONFERENCE PAPER; DRUG EFFICACY; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; METHODOLOGY; PRIORITY JOURNAL;

EID: 0032697092     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053176     Document Type: Conference Paper

References (26)

1. Blethen SL, Baptisla J, Kuntze J, Foley T, LaFranchi S, Johanson A: Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. The Genentech Growth Study Group. J Clin Endocrinol Metab 1997;82:418-420.
2. Rosenfeld RG, Attie KM, Franc J, Brasel JA, Burstein S, Cara JF, Chernausek S, Gotlin RW, Kuntze J, Lippe BM, Mahoney CP, Moore WV, Saenger P, Johanson AJ: Growth hormone therapy of Turner's syndrome: beneficial effect on adult height. J Pediatr 1998;132:319-324.
3. Haffner D, Wuhl E, Schaefer F, Nissel R, Tönshoff B, Mehls O: Factors predictive of the short-and long-term efficacy of growth hormone treatment in prepubertal children with chronic renal failure. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure: J Am Soc Nephrol 1998;9:1899-1907.
4. Mehls O, Wuhl E, Haffner D, Schaefer F, Tönshoff B: Growth hormone treatment of short children with chronic renal failure before and after renal transplantation: rationale and recent results. Nephrol Dial Transplant 1996; 11:1747-1750.
5. Rosén T, Bengtsson B-Å: Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990;336:285-288.
6. Russell-Jones DL, Weissberger AJ, Bowes SB, Kelly JM, Thomason M, Umpleby AM, Jones RH, Sönksen PH: Protein metabolism in growth hormone deficiency, and effects of growth hormone replacement therapy. Acta Endocrinol (Copenh) 1993:128(suppl 2):44-47.
7. Salomon F, Cuneo RC, Hesp P, Sönksen PH: The effects of treatment of recombinant human growth hormone on body composition and metabolism is adults with growth hormone deficiency. N Engl J Med 1989;321:1797-1803.
8. Jørgensen JOL, Thuesen L, Muller J, Ovesen P, Skakkebæk NE, Christiansen JS: Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. Eur J Endocrinol 1994;130:224-228.
9. Cuneo RC, Salomon F, Wiles CM. Hesp R, Sönksen PH: Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol 1991; 70:688-694.
10. Wirén L, Bengtsson B-Å, Johannsson G: Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency. Clin Endocrinol 1998;48:613-620.
11. Johannsson G, Grimby G, Sunnerhagen KS, Bengtsson B-Å: Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. J Clin Endocrinol Metab 1997;82:2877-2884.
12. Lucidi P, Lauteri M, Laureti S, Celleno R, Santoni S, Volpi E, Angeletti G, Santeusanio F, De Feo P: A dose-response study of growth hormone (GH) replacement on whole body protein and lipid kinetics in GH-deficient adults. J Clin Endocrinol Metab 1998;83:353-357.
13. Growth Hormone Research Society: Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 1998;83:379-381.
14. Roche AF, Heymsfield SB, Lohman TG (eds): Human Body Composition, Human Kinetics. Champaign, Ill., 1996.
15. Ellis KJ: Human body composition: in vivo methods. Physiol Rev. In press.
16. Zi-Mian W, Pierson RN Jr, Heymsfield SB: The five-level model: a new approach to organizing body-composition research. Am J Clin Nutr 1992;56:19-28.
17. Deurenber P, Schutz Y: Body composition: overview of methods and future directions of research. Ann Nutr Metab 1995;39:325-333.
18. Pierson RN Jr, Wang J, Thornton JC: Measurement of body composition: applications in hormone research. Horm Res 1997;48(suppl 1): 56-62.
19. Møller J, Frandsen E, Fisker S, Jørgensen JOL, Christiansen JS: Decreased plasma and extracellular volume in growth hormone deficient adults and the acute and prolonged effects of GH administration: a controlled experimental study. Clin Endocrinol 1996;44:533-539.
20. Hoffman DM, Crampton L, Sernia C, Nguyen TV, Ho KKY: Short term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure. J Clin Endocrinol Metab 1996;81:1123-1128.
21. Jørgensen JO, Pedersen SA, Thuesen L, Jorgensen J, Ingemann-Hansen T, Skakkebaek NE, Christiansen JS: Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989;1:1221-1225.
22. Amato G, Carella C, Fazio S, Montagna GL, Cittadini A, Sabatini D, Marciano-Mone C, Saccà L, Bellastella A: Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab 1993;77:1671-1676.
23. Bengtsson B-Å, Edén S, Lönn L, Kvist H, Stokland A, Lindstedt G, Bosæus I, Tölli J, Sjöström L, Isaksson OGP: Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993;76:309-317.
24. Carroll PV, Christ ER, and the members of the Growth Hormone Research Society Scientific Committee (Bengtsson B-Å, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sönksen PH, Tanaka T, Thorner M): Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 1998;83:382-395.
25. Horber FF, Marsh HM, Haymond MW: Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans. Diabetes 1990;40:141-149.
26. Horber FF, Haymond MW: Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 1990;86:265-272.