Superantigens are presented by and activate thymocytes from infants

Experimental and Clinical Immunogenetics

Volumn 16, Issue 4, 1999, Pages 226-233

  Thulesen, S ^c   Jorgensen A ^c   Gerwien, J ^c   Dohlsten, M ^a   Nissen, M Holst ^c   Odum N ^c   Ropke C ^b  

^a Pharmacia and Upjohn   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NONE

Author keywords

Antigen presentation; Cell culture; Human; Major histocompatibility complex class II; Superantigens; Thymocytes; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; THYMOCYTE;

EID: 0032696924     PISSN: 02549670     EISSN: None     Source Type: Journal    
DOI: 10.1159/000019114     Document Type: Article

References (19)

1. Park SH, Bae YM, Kim TJ, Ha IS, Kim S, Chi JG, Lee SK: HLA-DR expression in human fetal thymocytes. Hum Immunol 1992;33:294-298.
2. Choi EY, Park WS, Jung KC, Chung DH, Bae YM, Kim TJ, Song HG, Kim SH, Ham DI, Hahn JH, Kim J, Kim K, Hwang TS, Park SH: Thymocytes positively select thymocytes in human system. Hum Immunol 1997;54:15-20.
3. von Boehmer H: Developmental biology of T-cells in T-cell receptor transgenic mice. Annu Rev Immunol 1990;8:531-556.
4. Sprent J, Lo D, Gao E-K, Ron Y: T-cell selection in the thymus. Immunol Rev 1988;101:173-190.
5. Anderson G, Owen JJ, Moore NC, Jenkinson EJ: Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro. J Exp Med 1994;179: 2027-2031.
6. Carding SR, Hayday AC, Bottomly K: Cytokines in T-cell development. ImmunoJ Today 1991;12:239-245.
7. Ernst BB, Surch CD, Sprent J: Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures. J Exp Med 1996; 183:1235-1240.
8. Pircher H, Brduscha K, Steinhoff U, Kasai M, Mizuochi T, Zinkernagel RM, Hengartner H, Kyewski B, Müller K-P: Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells. Eur J Immunol 1993;23:669-674.
9. Pawlowski T, Elliott JD, Loh DY, Staerz UD: Positive selection of T lymphocytes on fibroblasts. Nature 1993;364:642-645.
10. Anderson G, Jenkinson EJ, Moore NC, Owen JJT: MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 1993;362:70-73.
11. Kruisbeek AM: Development of ab T cells. Curr Opin Immunol 1993;5: 227-234.
12. Chatila T, Geha RS: Signal transduction by microbial superantigens via MHC class II molecules. Immunol Rev 1993;131:43-60.
13. Newton DW, Dolsten M, Olsson C, Segren S, Lundin KEA, Lando PA, Kalland T, Koth M: Mutations in the MHC class II binding domains of staphylococcal enterotoxin A differently affect T cell receptor Vbeta specificity. J Immunol 1996;157: 3988-3994.
14. Jørgensen A, Wiencke AK, la Cour M, Kaestel CG, Madsen HO, Hamann S, Lui GM, Scherfig E, Prause JU, Svejgaard A, Ødum N, Nissen MH, Röpke C: Human retinal pigment epithelial cell-induced apoptosis in activated T cells. Invest Ophthalmol Vis Sci 1998;39:1590-1599.
15. Rabinovitch A, Torres RM, Engel D: Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: Applications to study of cell activation and the cell cycle of murine LY-1 B cells. J Immunol 1986;136:2769.
16. Ritter MA, Boyd RL: Development in the thymus: It takes two to tango. Immunol Today 1993;14:462-469.
17. van Ewijk W, Shores EW, Singer A: Crosstalk in the mouse thymus. Immunol Today 1994;15:214-217.
18. Jørgensen A, Nielsen M, Svejgaard A, Ledbetter JA, Ødum N, Röpke C: Human thymic epithelial cells present superantigens to T-cell lines and thymocytes. Exp Clin Immunogenet 1996;13:192-203.
19. Nielsen M-B, Ødum N, Gerwien J, Svejgaard A, Bendtzen K, Bregenholdt S, Röpke C, Geisler C, Dohlsten M, Kaltoft K: Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines. Tissue Antigens, 1998;52: 530-538.