Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1

Applied Microbiology and Biotechnology

Volumn 52, Issue 4, 1999, Pages 484-488

  Fernandez M J ^a,d   Adrio, J L ^a,e   Piret, J M ^b   Wolfe, S ^c   Ro, S ^c   Demain, A L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c SIMON FRASER UNIVERSITY   (Canada)

^d INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

^e Avenida de Antibioóticos 59 61   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; CEPHALOSPORIN DERIVATIVE; PENICILLIN G;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; DRUG TRANSFORMATION; FUNGUS CULTURE; FUNGUS GROWTH; MYCELIUM; NONHUMAN; STREPTOMYCES CLAVULIGERUS;

ALCOHOLS; BIOTRANSFORMATION; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; ETHANOL; METHANOL; PENICILLIN G; PENICILLINS; STREPTOMYCES; TIME FACTORS;

ACTINOBACTERIA (CLASS); FUNGI; STREPTOMYCES CLAVULIGERUS; UNCULTURED ACTINOMYCETE;

EID: 0032694601     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051549     Document Type: Article

References (12)

1. Arnosti DN, Singer VL, Chamberlin, MJ (1986) Characterization of heat shock in Bacillus subtilis. J Bacteriol 168:1243-1249
2. Cho H, Adrio JL, Luengo JM, Wolfe S, Ocran S, Hintermann G, Piret JM, Demain AL (1998) Elucidation of conditions allowing conversion of penicillin G and other penicillins to deaceto xycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1. Proc Natl Acad Sci USA 95:11544-11548
3. Demain AL (1990) Production of beta-lactam antibiotics and its regulation. Proc Natl Sci Counc Repub China 15:251-265
4. Doull JL, Singh AK, Hoare M, Ayer SW (1994) Conditions for the production of jadomycin B by Streptomyces venezuelae ISP5230: effects of heat shock, ethanol treatment and phage infection. J Indust Microbiol 13:120-125
5. Guglielmi G, Mazodier P, Thompson CJ, Davies J (1991) A survey of the heat shock response in four Streptomyces species reveals two groEL-like genes and three Gro-EL like proteins in Strep tomyces albus. J Bacteriol 173:7374-7381
6. Jensen SE, Demain AL (1994) Beta-lactams. In: Vining LC, Stuttard C (eds) Genetics and biochemistry of antibiotic production Butterworth-Heinemann, Boston, pp 239-268
7. Kohsaka M, Demain AL (1976) Conversion of isopenicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium. Biochem Biophys Res Commun 70:465-473
8. Lee PC, Bochner BR, Ames BN (1983) AppppA, heat shock stress and cell oxidation. Proc Natl Acad Sci USA 80: 7496-7500
9. Liras P, Asturias JA, Martin JF (1990) Phosphate control se quences involved in transcriptional regulation of antibiotics biosynthesis. Tibtech 8: 184-189
10. Mahro B, Demain AL (1987) In vivo conversion of penicillin N into a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus. Appl Microbiol Biotechnol 27:272-275
11. Qoronfleh MW, Streips UN, Wilkinsen BJ (1990) Basic features of the staphylococcal heat shock response. Antonie Van Lee uwenhoek 58: 79-86
12. Shen YQ, Wolfe S, Demain AL (1984) Desacetoxycephalosporin C synthetase: importance of order of cofactor/reactant addition. Enzyme Microb Technol 6: 402-404