N-acetyl-cysteine inhibition of encephalomyelitis Theiler's virus- induced nitric oxide and tumour necrosis factor-α production by murine astrocyte cultures

BioFactors

Volumn 10, Issue 2-3, 1999, Pages 187-193

  Molina Holgado, F ^a   Hernanz, A ^b   De La Fuente, M ^c   Guaza, Carmen ^a  

^a INSTITUTO CAJAL   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Astrocyte cultures; N acetyl cysteine; Nitric oxide; Theiler's virus; Tumour necrosis factor

Indexed keywords

ACETYLCYSTEINE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ASTROCYTE; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DEMYELINATION; ENCEPHALOMYELITIS; ENZYME SYNTHESIS; HISTOPATHOLOGY; IMMUNE RESPONSE; MICROGLIA; MOLECULAR INTERACTION; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; SUPERNATANT; VIRUS INDUCTION;

EID: 0032694035     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520100215     Document Type: Conference Paper

References (33)

1. E. Ban, L.L. Sarlieve and F.G. Haour, Interleukin-1 binding sites on astrocytes, Neuroscience 3 (1993), 725-733.
2. E.N. Benveniste, Inflammatory cytokines within the central nervous system: sources, function and mechanisms of action, Am. J. Physiol. 263 (1992), C1-C16.
3. K.M. Boje and P.K Arora, Microglial-produced nitric oxide and reactive nitrogen oxides mediates neuronal cell death, Brain Res. 587 (1992), 250-256.
4. J. Boos and J.H. Kim, Evidence of a viral etiology of multiple sclerosis, in: Handbook of Multiple Sclerosis, S.D. Cook, ed., Marcel Dekker, New York, NY, 1990, pp. 41-62.
5. D.S. Bredt and S.H. Snyder, Isolation of nitric oxide synthase, a calmodulin-requiring enzyme, Proc. Natl. Acad. Sci. USA 87 (1990), 682-685.
6. C.C. Chao, S. Hu, W.S Sheng, D. Bu, M.I. Bukrinsky and P.K. Petterson, Cytokines-stimulated astrocytes damage human neurons via nitric oxide mechanism, GLIA 16 (1996), 276-284.
7. M. Endöh, K. Maiese and J.A. Wagner J., Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia, Brain Res. 651 (1994), 91-100.
8. E. Galea, D.L Feinstein and D.J. Reis, Induction of calcium independent nitric oxide synthase activity in primary cultures of astrocytes, Proc. Natl. Acad. Sci. USA 89 (1992), 10945-10949.
9. 15N nitrate in biological fluids, Anal. Biochem. 126 (1982), 131-138.
10. P.M. Hoffman, D.R. Hinton, K. Johnson and J.E. Merrill, Tumor necrosis factor identified in multiple sclerosis brains, J. Exp. Med. 170 (1989), 607-612.
11. D.G. Hooper, T. Ohnishi, R. Kean, Y. Numagami, B. Dietzschold and H. Koprowski, Local nitric oxide production in viral and autoimmune diseases of the central nervous system, Proc. Natl. Acad. Sci. USA 92 (1995), 5312-5316.
12. H. Koprowski, Y.M. Zheng, E. Hebert-Katz, N. Fraser, L. Rorke, F. Fang, C. Hanlon and B. Dietzshol, In vivo expression of inducible nitric oxide synthase in experimentally induced neurological diseases, Proc. Natl. Acad. Sci. USA 90 (1993), 3024-3027.
13. O. Kranich, R. Dringen, M. Sandberg and B. Hamprecht, Utilization of cysteine and cysteine precursors for the synthesis of gluthatione in astroglial cultures: preference for cystine, Glia 22 (1998), 11-18.
14. S.C. Lee, D.W. Dickson, W. Liu and C.F. Brosnan, Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ, J. Neuroimmunol. 46 (1993), 9-24.
15. A.P. Lieberman, P.M. Pitha, H.S. Shin and M.L. Shin, Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus, Proc. Natl. Acad. Sci. USA. 86 (1989), 6348-6352.
16. H.L. Lipton, Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination, Infect. Immunol. 11 (1975), 1147-1155.
17. J. Louis, E. Magal, S. Takayama and S. Varon, CNTF protection of oligodendrocytes against natural and tumor-necrosis-factor-induced death, Science 259 (1993), 671-689.
18. J.E. Merril, L.J. Ignarro, M.P. Sherman, J. Melinek and TE. Lane, Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide, J. Immunol. 151 (1993), 2131-2141.
19. S. Milstein, N. Sakai, B.J. Brew, C. Krieger, J.H. Vickers, K. Saito and M.P. Heyes, Cerebrospinal fluid nitrite/nitrate levels in neurological diseases, J. Neurochem. 3 (1994), 1178-1180.
20. F. Molina-Holgado, A. Lledó and C. Guaza, Evidence for cyclooxygenase activation by nitric oxide in astrocytes, GLIA 15 (1995), 167-172.
21. S. Moncada, R.M.J. Palmer and E.A. Higgs, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43 (1991), 109-142.
22. C. Nathan and Q.W. Xie, Regulation and biosynthesis of nitric oxide, J. Biol. Chem. 269 (1994), 13725-13728.
23. B.A. Neuschwander-Tetri, J.M. Bellezo, R.S. Britton, B.R. Bacon and E.S. Fox, Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells, Biochem. J. 320 (1996), 1005-1010.
24. K. Pahan, F.G. Sheikh, M. Khan, A.M.S. Namboodiri and I. Singh, Sphingomyelinase and ceramide stimulate the expression of inducible nitric oxide synthase in rat primary astrocytes, J. Biol. Chem. 273 (1998), 2591-2600.
25. Y. Qi and M.C. Dal Canto, Effect of Theiler's murine encephalomyelitis virus and cytokines on cultures oligodendrocytes and astrocytes, J. Neurosci. Res. 45 (1996), 364-374.
26. N. Rubio, C. De Felipe and C. Torres, Theiler's murine encephalomyelitis virus-binding activity on neural cell lines and tissues, J. Gen. Virol. 71 (1990), 2867-2872.
27. N. Rubio and C. Torres, IL-1, IL-2 and IFN-γ production by Theiler's virus-induced encephalomyelitis SJL/J mice, Immunology 74 (1991), 284-289.
28. K.W. Selmaj and C.S. Raine, Tumor necrosis factor mediated myelin and olygodendrocyte damage in vitro, Ann. Neurol. 23 (1988), 339-346.
29. M.L. Simmons and S. Murphy, Induction of nitric oxide synthase in glial cells, J. Neurochem. 59 (1992), 897-905.
30. N. Sun, D. Grzybicki, R.F. Castro, S. Murphy and S. Perlman, Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus, Virology 213 (1995), 482-493.
31. A.M. Vam Dam, J. Bauer, A. Man, W.K.H. Hing, C. Marquette, F.J.H. Tilders and F Berkenbosch, Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin, J. Neurosci. Res. 40 (1995), 251-260.
32. V.M.A. Vincent, A.M. Van Dam, J.H.A. Persoons, K. Schotanus, H.W. Steinbusch M. Schoffelmeer and F. Berkenbosch, Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1β production in rat microglial cells of endotoxin-treated mixed glial cells cultures, GLIA 17 (1996), 94-102.
33. Y.M. Zheng, M.H.H. Schafer, E. Ehihe, H. Sheng, S. Corisdeo, Z.F. Fu, H. Koprowski and B. Dietzschold, Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase, J. Virol. 67 (1993), 5786-5791.