Quantitative cytomegalovirus DNA level in the blood and its relationship to cytomegalovirus retinitis in patients with acquired immune deficiency syndrome

Ophthalmology

Volumn 106, Issue 1, 1999, Pages 133-141

  Tufail, Adnan ^a   Moe, Ardis A ^b   Miller, Marjorie J ^c   Wagar, Elizabeth A ^c   Bruckner, David A ^c   Holland, Gary N ^a,d  

^a JULES STEIN EYE INSTITUTE   (United States)

^b Center for AIDS Research and Education (CARE)   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; VIRUS DNA;

ADOLESCENT; ADULT; AIDS RELATED COMPLEX; ARTICLE; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS; FEMALE; FOLLOW UP; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; PATHOPHYSIOLOGY; PILOT STUDY; PROSPECTIVE STUDY; RETINITIS; VIREMIA; VIROLOGY; VIRUS ACTIVATION;

ADOLESCENT; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS RETINITIS; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; VIREMIA; VIRUS ACTIVATION;

EID: 0032622169     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-6420(99)90015-5     Document Type: Article

References (38)

1. Holland GN, Tufail A, Jordan MC. Cytomegalovirus diseases. In: Pepose JS, Holland GN, Wilhelmus KR, eds. Ocular Infection and Immunity. St. Louis: Mosby, 1996;1088-129.
2. Hoover DR, Peng Y, Saah A, et al. Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. Arch Ophthalmol 1996;114:821-7.
3. Pepose JS, Holland GN, Nestor MS, et al. Acquired immune deficiency syndrome. Pathogenic mechanisms of ocular disease. Ophthalmology 1985;92:472-84.
4. Salmon D, Lacassin F, Harzic M, et al. Predictive value of cytomegalovirus viraemia for the occurrence of CMV organ involvement in AIDS. J Med Virol 1990;32:160-3.
5. Zurlo JJ, O'Neill D, Polis MA, et al. Lack of clinical utility of cytomegalovirus blood and urine cultures in patients with HIV infection. Ann Intern Med 1993;118:12-7.
6. MacGregor RR, Pakola SJ, Graziani AL, et al. Evidence of active cytomegalovirus infection in clinically stable HIV-infected individuals with CD4-positive lymphocyte counts below 100/microliters of blood: features and relation to risk of subsequent CMV retinitis. J Acquir Immune Defic Syndr Hum Retrovirol 1995;10:324-30.
7. Hansen KK, Ricksten A, Hofmann B, et al. Detection of cytomegalovirus DNA in serum correlates with clinical cytomegalovirus retinitis in AIDS. J Infect Dis 1994;170:1271-4.
8. Francisci D, Tosti A, Preziosi R, et al. Role of antigenemia assay in the early diagnosis and prediction of human cytomegalovirus organ involvement in AIDS patients. Eur J Clin Microbiol Infect Dis 1995;14:498-503.
9. Bowen EF, Sabin CA, Wilson P, et al. Cytomegalovirus (CMV) viraemia detected by polymerase chain reaction identifies a group of HIV-positive patients at high risk of CMV disease. AIDS 1997;11:889-93.
10. Dodt KK, Jacobsen PH, Hofmann B, et al. Development of cytomegalovirus (CMV) disease may be predicted in HIV-infected patients by CMV polymerase chain reaction and the antigenemia test. AIDS 1997;11:F21-F28.
11. Spector SA, Wong R, Hsia K, et al. Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients. J Clin Invest 1998;101:497-502.
12. Holland GN, Buhles WC Jr., Mastre B, Kaplan HJ. A controlled retrospective study of ganciclovir treatment for cytomegalovirus retinopathy. Use of a standardized system for the assessment of disease outcome. UCLA CMV Retinopathy Study Group. Arch Ophthalmol 1989;107:1759-66.
13. Imbert-Marcille B, Cantarovich D, Boedec S, Vernoux L, Soulillou J, Billaudel S. Evaluation of a new quantification method for cytomegalovirus DNA in leukocytes: clinical value in renal transplant patients. Scand J Infect Dis 1995; Suppl 99:15-6.
14. Merigan TC. Individualization of therapy using viral markers. J Acquir Immune Defic Syndr Hum Retrovirol 1995;10(Suppl 1):541-6.
15. Harrigan R. Measuring viral load in the clinical setting. J Acquir Immune Defic Syndr Hum Retrovirol 1995;10(Suppl 1):534-40.
16. Saltzman RL, Quirk MR, Jordan MC. High levels of circulating cytomegalovirus DNA reflect visceral organ disease in viremic immunosuppressed patients other than marrow recipients. J Clin Invest 1992;90:1832-8.
17. Wolf DG, Spector SA. Early diagnosis of human cytomegalovirus disease in transplant recipients by DNA amplification in plasma. Transplantation 1993;56:330-4.
18. Goodrich JM, Bowden RA, Fisher L, et al. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann Intern Med 1993;118:173-8.
19. Goodrich JM, Mori M, Gleaves CA, et al. Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N Engl J Med 1991;325: 1601-7.
20. Singh N, Yu VL, Mieles L, et al. High-dose acyclovir compared with short-course preemptive ganciclovir therapy to prevent cytomegalovirus disease in liver transplant recipients. A randomized trial. Ann Intern Med 1994;120:375-81.
21. Bowen EF, Wilson P, Atkins M, et al. Natural history of untreated cytomegalovirus retinitis. Lancet 1995;346:1671-3.
22. Wetherill PE, Landry ML, Alcabes P, Friedland G. Use of a quantitative cytomegalovirus (CMV) antigenemia test in evaluating HIV + patients with and without CMV disease. J Acquir Immune Defic Syndr Hum Retrovirol 1996;12:33-7.
23. Revello MG, Percivalle E, Di Matteo A, et al. Nuclear expression of the lower matrix protein of human cytomegalovirus in peripheral blood leukocytes of immunocompromised viraemic patients. J Gen Virol 1992;73(Pt2):437-42.
24. Erice A, Holm MA, Gill PC, et al. Cytomegalovirus (CMV) antigenemia assay is more sensitive than shell vial cultures for rapid detection of CMV in polymorphonuclear blood leukocytes. J Clin Microbiol 1992;30:2822-5.
25. Landry ML, Ferguson D, Cohen S, et al. Effect of delayed specimen processing on cytomegalovirus antigenemia test results. J Clin Microbiol 1995;33:257-9.
26. Boeckh M, Woogerd PM, Stevens-Ayers T, et al. Factors influencing detection of quantitative cytomegalovirus antigenemia. J Clin Microbiol 1994;32:832-4.
27. Gerna G, Zipeto D, Parea M, et al. Monitoring of human cytomegalovirus infections and ganciclovir treatment in heart transplant recipients by determination of viremia, antigenemia, and DNAemia. J Infect Dis 1991;164:488-98.
28. Drouet E, Boibieux A, Michelson S, et al. Polymerase chain reaction detection of cytomegalovirus DNA in peripheral blood leukocytes as a predictor of cytomegalovirus disease in HIV-infected patients. AIDS 1993;7:665-8.
29. Rasmussen L, Morris S, Zipeto D, et al. Quantitation of human cytomegalovirus DNA from peripheral blood cells of human immunodeficiency virus-infected patients could predict cytomegalovirus retinitis. J Infect Dis 1995;171:177-82.
30. Shibata D, Martin WJ, Appleman MD, et al. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis 1988;158: 1185-92.
31. Spector SA, Merrill R, Wolf D, Dankner WM. Detection of human cytomegalovirus in plasma of AIDS patients during acute visceral disease by DNA amplification. J Clin Microbiol 1992;30:2359-65.
32. Gerna G, Baldanti F, Sarasini A, et al. Effect of foscarnet induction treatment on quantitation of human cytomegalovirus (HCMV) DNA in peripheral blood polymorphonuclear leukocytes and aqueous humor of AIDS patients with HCMV retinitis. The Italian Foscarnet Study Group. Antimicrob Agents Chemother 1994;38:38-44.
33. Gerna G, Zipeto D, Percivalle E, et al. Human cytomegalovirus infection of the major leukocyte subpopulations and evidence for initial viral replication in polymorphonuclear leukocytes from viremic patients. J Infect Dis 1992;166:1236-44.
34. Taylor-Wiedeman J, Sissons JG, Borysiewicz LK, Sinclair JH. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 1991;72:2059-64.
35. Zipeto D, Morris S, Hong C, et al. Human cytomegalovirus (CMV) DNA in plasma reflects quantity of CMV DNA present in leukocytes. J Clin Microbiol 1995;33:2607-11.
36. Mazzulli T, Wood S, Chua R, Walmsley S. Evaluation of the Digene Hybrid Capture System for detection and quantitation of human cytomegalovirus viremia in human immunodeficiency virus-infected patients. J Clin Microbiol 1996;34: 2959-62.
37. Pocock SJ, Hughes MD, Lee RJ. Statistical problems in the reporting of clinical trials. A survey of three medical journals. N Engl J Med 1987;317:426-32.
38. Studies of Ocular Complications of AIDS (SOCA) in collaboration with the AIDS Clinical Trial Group. Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir. J Infect Dis 1997;176:50-8.