Drug metabolizing enzymes in lymphocytes

Journal of Biochemical and Molecular Toxicology

Volumn 13, Issue 3-4, 1999, Pages 223-226

  Raucy, J L ^a   Ingelman Snndberg, M ^b   Carpenter, S ^a   Rannug, A ^b   Rane, A ^c   Franklin, M ^d   Romkes, M ^e  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF UTAH   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENZYME;

BLOOD; DRUG DETOXIFICATION; ENZYMOLOGY; HUMAN; LYMPHOCYTE; METABOLISM; REVIEW;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYMES; HUMANS; LYMPHOCYTES; METABOLIC DETOXICATION, DRUG;

EID: 0032618539     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-0461(1999)13:3/4<223::aid-jbt14>3.0.co;2-z     Document Type: Article

References (12)

1. de Waziers I, Cugenenc PH, Yang CS, Leoux J-P, Beaune PH. Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther 1990;253:387-394.
2. Wheeler CW, Guenthner TM. Cytochrome P450-dependent metabolism of xenobiotics in human lung. J Biochem Toxicol 1991;6:163-169.
3. Hedlund E, Gustafsson JÅ, Warner M. Cytochrome P450 in the brain: 2B or not 2B. Trends Pharmacol Sci 1998;19:82-85.
4. Kluwe WM, Hook JB. Effects of environmental chemicals on kidney metabolism and function. Kidney Int 1980;18:648-655.
5. Gonzalez FJ, Gelboin HV. Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression. Prog Clin Biol Res 1991;372:11-20.
6. Raucy JL, Schultz ED, Wester MR, Arora S, Johnston DE, Omdahl JL, Carpenter SP. Human lymphocyte cytochrome P450 2E1: a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity. Drug Metab Disp 1997;25:1429-1435.
7. Song BJ, Veech RL, Saenger P. Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics. J Clin Endocrinol Metab 1990;71:1036-1040.
8. Raucy JL, Curley G, Carpenter SP. The use of lymphocytes for assessing ethanol-mediated alterations in the expression of hepatic CYP2E1. Alcoholism Clin Exp Res 1995;19:1369-1375.
9. Soh Y, Rhee HM, Sohn DH, Song BJ. Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting. Biochem Biophys Res Commun 1996;227:541-546.
10. 1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Res 1985;13:4503-4520.
11. Janardan SK, Lown KS, Schmiedlin-Ren P, Thummel KE, Watkins PB. Selective expression of CYP3A5 and not CYP3A4 in human blood. Pharmacogenetics 1996;6:379-385.
12. Omiecinski CJ, Aicher L, Holubkov R, Checkoway H. Human peripheral lymphocytes as indicators of microsomal epoxide hydroxylase activity in liver and lung. Pharmacogenetics 1993;3:150-158.