Impact of delta-9-tetrahydrocannabinol and metabolites on the immune system;Impact du delta-9-tetrahydrocannabinol et ses metabolites sur le systeme immunitaire

Acta Clinica Belgica

Volumn 54, Issue SUPPL. 1, 1999, Pages 39-43

  Masset, D ^a   Bourdon, J H ^a   Arditti Djiane, J ^a   Jouglard, J ^a  

^a Centre Antipoisons de Marseille   (France)

Author keywords

Cannabis; Delta 9 Tetrahydrocannabinol; Immune system; Leukotrines; Tumoral necrosis factor

Indexed keywords

ADENYLATE CYCLASE; ARACHIDONIC ACID; CANNABINOID RECEPTOR; CANNABIS; DRONABINOL; GAMMA INTERFERON; GLUTAMIC ACID; HISTAMINE; INTERLEUKIN 1; LEUKOTRIENE; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; CANNABINOID; PSYCHOTROPIC AGENT; TETRAHYDROCANNABINOL;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; BLOOD VESSEL PERMEABILITY; BRONCHOSPASM; CACHEXIA; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CYTOKINE PRODUCTION; DRUG DEPENDENCE; DRUG EFFECT; HUMAN; IMMUNE SYSTEM; LYMPHOCYTE; MACROPHAGE; CHEMISTRY; IMMUNOCOMPETENCE; IMMUNOLOGY; METABOLISM; REVIEW;

CANNABINOIDS; HUMANS; IMMUNOCOMPETENCE; INTERFERON TYPE II; INTERLEUKIN-1; PSYCHOTROPIC DRUGS; TETRAHYDROCANNABINOL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032613058     PISSN: 00015512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. Mechoulam R., Braun P., Gaoni Y. A stereospecific synthesis of (-)-delta 1- and (-)-delta 1(6)-tetrahydrocannabinols. J Am Chem Soc 1967 Aug 16; 89 (17): 4552-4
2. Schwartz IS. Fungal sinusitis ands marijuana JAMA 1987 jun 5; 257 (21): 2914-5
3. Friedman H., Klein TW., Newton C., Daaka Y. Marijuana, receptors and immunomodulation. Adv. Exp. Med. Biol. 1995; 373: 103-113.
4. Matsuda LA., Lolait SJ., Brownstein MJ., Young AC., Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990 Aug 9; 346 (6284): 561-4.
5. Munro S., Thomas KL., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 1993 Sep 2; 365 (6441): 61-5.
6. Reggio PH., Seltzman HH., Compton DR., Prescott WR. Jr, Martin BR. Investigation of the role of the phenolic hydroxyl in cannabinoid activity. Mol Pharmacol. 1990 Dec; 38 (6): 854-62.
7. Reggio PH., Panu AM., Miles S Characterization of a region of steric interference at the cannabinoid receptor using the active analog approach. J Med Chem. 1993 Jun 11; 36 (12): 1761-71.
8. Musty RE., Reggio P., Consroe PA. Review of recent advances in cannabinoid research and the 1994 International Symposium on Cannabis and the Cannabinoids. Life Sci. 1995; 56 (23-24): 1933-40.
9. Diaz S., Specter S., Vanderhoek JY., Coffey RG. The effect of delta-9-tetrahydrocannabinol on arachidonic acid metabolism in human peripheral blood mononuclear cells. J Pharmacol Exp Ther. 1994 Mar; 268 (3): 1289-96.
10. Piani D., Fontana A. Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J Immunol. 1994 Apr 1; 152 (7): 3578-85.
11. Nakashima J., Tachibana M., Ueno M., Miyajima A, Baba S., Murai M Association between tumor necrosis factor in serum and cachexia in patients with prostate cancer. Clin Cancer Res. 1998 Jul; 4 (7): 1743-8.
12. Haslett PA. Anticytokine approaches to the treatment of anorexia and cachexia. Semin Oncol. 1998 Apr; 25 (2 Suppl 6): 53-7.
13. Pacifici R., Di Carlo S., Bacosi A., Zuccaro P. Macrophage functions in drugs of abuse-treated mice. Int J Immunopharmacol. 1993 Aug; 15 (6): 711-6.
14. Okutomi T., Nishizawa T., Inagawa H., Soma G., Minami M., Satoh M., Mizuno D. Inhibition of morphine dependence by a lipopolysaccharide from Pantoea agglomerons. Eur Cytokine Netw. 1992 Jul-Aug; 3 (4): 417-20.
15. Hurwitz AA., Berman JW., Lyman WD. The role of the blood-brain barrier in HIV infection of the central nervous system. Adv Neuroimmunol. 1994; 4 (3): 249-56
16. Gelbard HA., Dzenko KA., DiLoreto D., del Cerro C., del Cerro M., Epstein LG. Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev Neurosci. 1993; 15 (6): 417-22.
17. Eshhar N., Striem S., Kohen R., Tirosh O., Biegon A. Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist. Eur J Pharmacol. 1995 Sep 5; 283 (1-3): 19-29
18. Lyman WD., Sonett JR., Brosnan CF., Elkin R., Bornstein MB. Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. J Neuroimmunol. 1989 Jun; 23 (1): 73-81.
19. Sawaya BE., Thatikunta P., Denisova L., Brady J., Khalili K., Amini S. Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells. J Neuroimmunol. 1998 Jul 1; 87 (1-2): 33-42.
20. Lissori P., Ressentini M., Mauri D., Esposti G., Rossi G., Legname G., Fraschini F. Effect of tetra-hydrocannabinol on melatonin secretion in Man. Hormone and Metabolic research 18 (1986) 77-78