Between acetylcholinesterase molecule and its natural substrate to study the effects of inhibitors and reactivators on enzyme activity

Life Sciences

Volumn 65, Issue 21, 1999, Pages PL253-PL260

  Yingge, Zhang ^a   Delu, Zhao ^a   Chunli, Bai ^b   Chen, Wang ^b  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Acetylcholine; Acetylcholinesterases; Atomic force microscopy; Force spectroscopy

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; NERVE GAS; ORGANOPHOSPHORUS COMPOUND; PRALIDOXIME; TOXIC SUBSTANCE; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; CHEMICAL WARFARE AGENT; IMMOBILIZED ENZYME; PYRIDINIUM DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; COMPUTER MODEL; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; FORCE; MOLECULAR INTERACTION; REACTION ANALYSIS; SPECTROSCOPY; ANIMAL; CHEMISTRY; KINETICS; METABOLISM; TORPEDO;

MICA;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANIMALS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ENZYMES, IMMOBILIZED; KINETICS; MICROSCOPY, ATOMIC FORCE; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; TORPEDO;

EID: 0032608281     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0024-3205(99)00494-4     Document Type: Article

References (20)

1. B. Ballantyne, & T.C. Marrs, Clinical and Experimental Toxicology of Organophosphates and Carbamates, Butterworth-Heinemann Inc. Oxford(1992).
2. G. Binig, C.F. Quate, and C. Gerber, Phys. Rev. Lett. 56 930-933 (1986).
3. B. Ret, and A. Fourcad, Nucleic. Acid. Res. 26 2092-2097 (1998).
4. C.H. Chen, D.O. Clegg, and H.G. Hansma, Biochemistry 37 8262-8267 (1998).
5. B.L. Smith, D.R. Gallie, H. Le and P.K. Hansma, J. Struct. Biol. 119 109-117 (1997).
6. E.L. Florin, V.T. Moy, H.E. Gaub, Science 26 415-417 (1994).
7. V.T. Moy, E-L. Florin, H.E. Gaub, Science 266 257-259 (1994).
8. H. Grubmuller, B. Heymann, P. Tavan, Science 271 997-9 (1996).
9. A. Ishijima, T. Doi, K. Sakurada and T. Yanagida, Nature 352 301-306 (1991).
10. U. Dammer, O. Popescu, P. Wagner, D. Anselmetti, H-J. Guentherodt, G.N. Misevic, Science 267 1173-1175 (1995).
11. G.U. Lee, L.A. Chrisey, R.J. Colton, Science 266 771-773 (1994).
12. T. Boland, and B.D. Ratner, Proc.Natl. Acad. Sci. USA 92 5297-5301 (1995).
13. Y.G. Zhang, C.L. Bai, C. Wang, D.L. Zhao, M. Su, Z. Lin and F. Tian, Science in China (Series B) 42 (1999), in press
14. M.J. Sun, T.D. Gao, Z.Y. Xing, H. Zhang, T.C. Zhou, Biochem. J. 1(2) 47-55 (1985).
15. GJ. Leggett, CJ. Roberts, PM. Willianms, MC. Davies, DE. Jackson, and SJB. Tendler, Langmuir, 9 2356(1993).
16. Y. Dudai, M. Herzberg, and I. Silman, Proc. Natl. Acad. Sci. USA. 70 2473-2476(1973).
17. D.R. Ripoll, C.H. Faerman, P.H. Axelsen, I. Silman, and J.L. Sussman, Proc. Natl. Acad. Sci. USA. 90 5128(1993).
18. J.L. Sussman, M. Harel, F. Frolow, C. Oefner, A. Goldman, L. Toker, I. Silman, Science 253 872(1991).
19. J. Kassa, Hum. Exp. Toxicol.17 331(1998).
20. F. Work, R. Widmann, O. Knopff, L. Szinicz, Arch. Toxicol. 72 237(1998).