Overexpression of S100β in Down's syndrome: Correlation with patient age and with β-amyloid deposition

Neuropathology and Applied Neurobiology

Volumn 25, Issue 5, 1999, Pages 387-393

  Royston, M C ^a   McKenzie, J E ^b   Gentleman, S M ^b   Sheng, J G ^d,g   Mann, D M A ^f   Griffin, W S T ^c,d,h   Mrak, R E ^c,e  

^a PETERBOROUGH CITY HOSPITAL   (United Kingdom)

^b Sir Alexander Fleming Bldg   (United Kingdom)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^h Education and Clinical Care Center   (United States)

Author keywords

amyloid; Astrocytes; Down's syndrome; Image analysis quantification; Inflammation; S100

Indexed keywords

AMYLOID BETA PROTEIN; PROTEIN S 100; ISOPROTEIN;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; ASTROCYTE; CLINICAL ARTICLE; COMPUTER ANALYSIS; DOWN SYNDROME; FEMALE; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGING; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; AGING; AMYLOID BETA-PROTEIN; ASTROCYTES; DOWN SYNDROME; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROTEIN ISOFORMS; S100 PROTEINS;

EID: 0032589810     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.1999.00196.x     Document Type: Article

References (28)

1. 1 Barger SW, Van Eldik LJ, S100β stimulates calcium fluxes in glial and neuronal cells. J Biol Chem 1992; 267: 9689-94
2. 2 Bhattacharyya A, Oppenheim RW, Prevette D, Moore BW, Brackenbury K, Ratner N. S100 is present in developing chicken neurons and Schwann cells and promotes neuron survival in vivo. J Neurobiol 1992; 23: 451-66
3. 3 Brugge KL, Nichols SL, Salmon DP et al. Cognitive impairment in adults with Down's syndrome: similarities to early cognitive changes in Alzheimer's disease. Neurology 1994; 44: 212-8
4. 4 Cummings BJ, Pike CJ, Shankle R, Cotman CW. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheitner's disease. Neurobiol Aging 1996; 17: 921-33
5. 5 da Cunha A, Jefferson JJ, Tyor WR, Glass JD, Jannotta FS, Vitkovic L. Gliosis in human brain: relationship to size but not other properties of astrocytes. Brain Res 1993; 600: 161-5
6. 6 Hilt DC, Kligman D. The S-100 family: a biochemical and functional overview. In Novel Calcium-Binding Proteins, Ed. CW Heizmann. Berlin: Springer-Verlag, 1991: 65-103
7. 7 Griffin WST, Stanley LC, Ling C et al. Brain interleukin 1 and S100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989; 86: 7611-5
8. 8 Griffin WST, Sheng JG, Roberts GW, Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution. J Neuropathol Exp Neurol 1995; 54: 276-81
9. 9 Griffin WST, Sheng JG, McKenzie J et al. Life-long overexpression of S100β in Down's syndrome: implications for Alzheimer pathogenesis. Neurobiol Aging 1998; 19: 401-5
10. 10 Griffin WST, Sheng JG, Royston MC et al. Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression. Brain Pathol 1998; 8: 65-72
11. 11 Kligman D, Marshak DR. Purification and characterization of a neurite extension factor from bovine brain. Proc Natl Acad Sci USA 1985; 82: 7136-9
12. 12 Li YK, Wong JZ, Sheng JG, Jones RA, Mrak RE, Griffin WST. S100β increases β-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. J Neurochem 1998; 71: 1421-8
13. 13 Mann DMA. The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Devel 1988; 43: 99-136
14. 14 Mann DMA, Esiri MM. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci 1989; 89: 169-79
15. 15 Mann DMA, Royston MC, Ravindra CR. Some morphometric observations on the brains of patients with Down's syndrome: their relationship to age and dementia. J Neurol Sci 1990; 99: 153-64
16. 16 Marshak DR. S100β as a neurotrophic factor. Prog Brain Res 1990; 6: 169-81
17. 17 McKenzie JE, Roberts GW, Royston MC. Quantification of Alzheimer-type neurofibrillary lesions by automated image analysis. Neurodegeneration 1996; 5: 251-8
18. 18 Mrak RE, Sheng JG, Griffin WST. Glial cytokines in Alzheimer's disease: review and pathogenic implications. Human Pathol 1995; 26: 816-23
19. 19 Mrak RE, Sheng JG, Criffin WST. Correlation of astrocytic S100β expression with dystrophic neurites in amyloid plaques of Alzheimer's disease, J Neuropathol Exp Neurol 1996; 55: 273-9
20. 20 Oliver C, Holland AJ. Down's syndrome and Alzheimer's disease - a review. Psych Med 1986; 16: 307-22
21. 21 Royston MC, Kodical NS, Mann DMA, Groom K, Landon M, Roberts GW. Quantitative analysis of β-amyloid deposition in Down's syndrome using computerized image analysis. Neurodegeneration 1994; 3: 43-51
22. 22 Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL. A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 1989; 48: 674-91
23. 23 Schafer BW, Heizmann CW. The S100 family of EF-hand calcium-binding proteins: functions and pathology. TIBS 1996; 21: 134-40
24. 24 Selinfreund RH, Barger SW, Pledger WJ, Van Eldik LJ, Neurotrophic protein S100β stimulates glial cell proliferation. Proc Natl Acad Sci USA 1991; 88: 3554-8
25. 25 Sheng JG, Mrak RK, Griffin WST. S100β protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques. J Neurosci Res 1994; 39: 398-404
26. 26 Sheng JG, Mrak RE, Griffin WST. Progressive neuronal injury associated with amyloid plaque formation in Alzheimer's disease. J Neuropathol Exp Neurol 1998; 57: 714-7
27. 27 Van Eldik LJ, Griffin WST. S100β expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochim Biophys Acta 1994; 1223: 398-403
28. 28 Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985; 17: 278-82