Polynitroxyl αα-hemoglobin (PNH) inhibits peroxide and superoxide-mediated neutrophil adherence to human endothelial cells

Free Radical Research

Volumn 31, Issue 1, 1999, Pages 53-58

  Okayama, Naotsuka ^a   Park, Jae H ^a   Coe, Laura ^a   Granger, D Neil ^a   Ma, Li ^b   Hisa, Carleton J C ^b   Alexander, J Steven ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b Synzyme Technologies Inc   (United States)

Author keywords

Catalase; Nitroxide; Oxidant; Superoxide

Indexed keywords

ANTIOXIDANT; HEMOGLOBIN VARIANT; HYDROGEN PEROXIDE; SUPEROXIDE; XANTHINE OXIDASE; BLOOD SUBSTITUTE; HEMOGLOBIN; NITROGEN OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYNITROXYL HEMOGLOBIN; XANTHINE;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NEUTROPHIL; OXYGEN AFFINITY; CELL CULTURE; CYTOLOGY; DRUG EFFECT; PHYSIOLOGY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BLOOD SUBSTITUTES; CELL ADHESION; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HEMOGLOBINS; HUMANS; HYDROGEN PEROXIDE; NEUTROPHILS; NITROGEN OXIDES; SUPEROXIDES; UMBILICAL VEINS; XANTHINE; XANTHINE OXIDASE;

EID: 0032588550     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715769900300591     Document Type: Article

References (10)

1. T. Matsubara, T. Ziff (1986). Superoxide anion release by human endothelial cells: synergism between a phorbol ester and a calcium ionophore. Journal of Cell Physiology 127: 207-210.
2. P. Kuppusamy, P. Wang, J.L. Zweier, M.C. Krishna, J.B. Mitchell, L. Ma, C.E. Trimble and C.J.C. Hsia (1996). Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin. Biochemistry 35: 7051-7057.
3. J. Russell, N. Okayama, J.S. Alexander, D.N. Granger and C.J.C. Hsia (1998). Pretreatment with polynitroxyl albumin (PNA) inhibits schemia-reperfusion induced leukocyte-endothelial cell adhesion. Free Radical Biology and Medicine 25: 153-159.
4. C. Beaulieu, E. Busch, J. Rother, A. de Crespigny, C.J. Hsia and M.E. Moseley (1998). Polynitroxyl albumin reduces infarct size in transient focal cerebral ischemia in the rat: potential mechanisms studied by magnetic resonance imaging. J. Cereb. Blood Flow Metab. 18(9): 1022-1031.
5. N. Yoshida, D.N. Granger, D.C. Anderson, R. Rothlein, C. Lane and P.R. Kvietys (1992). Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. American Journal of Physiology 262 (Heart Circulatory Physiology 31): H1891-H1898.
6. N. Okayama, H. Ichikawa, L. Coe, M. Itoh and J.S. Alexander (1998). Exogenous NO enhances hydrogen peroxide-mediated neutrophil adherence to cultured endothelial cells. American Journal of Physiology 274 (Lung Cellular Molecular Physiology 18): L820-L826.
7. M. Suzuki, M.B. Grisham and D.N. Granger (1994). Leukocyte-endothelial cell adhesive interactions: role of xanthine oxidase-derived oxidants. Journal of Leukocyte Biology 50: 488-494.
8. I. Kurose, R. Wolf, M.B. Grisham and D.N. Granger (1994). Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide. Circulation Research 74: 376-382.
9. H. Ichikawa, S. Flores, P.R. Kvietys, R.E. Wolf, T. Yoshikawa, D.N. Granger and T.Y. Aw (1997). Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. Circulation Research 81:922-931.
10. M.C. Krishna, A. Russo, J.B. Mitchell, S. Goldstein, H. Dafni and A. Samuni (1996). Do nitroxide antioxidants act as scavengers of superoxide or as SOD mimics. Journal of Biological Chemistry 271: 26026-26031.