Acceleration of wound healing in gastric ulcers by local injection of neutralising antibody to transforming growth factor β1

Gut

Volumn 39, Issue 2, 1996, Pages 172-175

  Ernst, H ^a,c   Konturek, P ^a   Hahn, E G ^a   Brzozowski, T ^b   Konturek, S J ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Gastric ulcer; Neutralising antibodies to TGF 1; Quality of wound healing; TGF 1; Wound healing

Indexed keywords

NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ULCER; ULCER HEALING;

EID: 0029837276     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.39.2.172     Document Type: Article

References (16)

1. Whitby DJ, Ferguson MWJ. Immunohistochemical localisation of growth factors in fetal wound healing. Dev Biol 1991; 147: 207-15.
2. Adzick NS, Lorenz HP. Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Ann Surg 1994; 220: 10-8.
3. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature 1990; 346: 371-4.
4. Ishimori A, Kawakami K, Inoue S, Kano A, Takahashi T, Asaki S, et al. Predictors of relapse in peptic ulcer. Hepatogastroenterology 1992; 39: 396-9.
5. Roberts AB, Sporn MB. The transforming growth factor-βs. In: Sporn MB, Roberts AB, eds. Peptide growth factors and their receptors I. Berlin: Springer Verlag, 1990: 421-32.
6. Shah M, Foreman DM, Ferguson MWJ. Control of scarring in adult wounds by neutralising antibody to transforming growth factor β. Lancet 1992; 339: 213-4.
7. Shiann P, Liao CH, Chen SH. Histological maturity of healed duodenal ulcers and ulcer recurrence after treatment with colloidal bismuth subcitrate or cimetidine. Gastroenterology 1991; 101: 1187-91.
8. Border WA, Brees D, Noble NA. Transforming growth factor-beta and extracellular matrix deposition in the kidney. In: Koide H, Hayashi T, eds. Extracellular matrix in the kidney. Basel: Karger, 1994: 140-5.
9. Guglietta A, Hervada T, Nardi C, Lesch A. Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats. Scand J Gastroenterol 1992; 27: 673-6.
10. Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992; 27: 649-55.
11. Konturek SJ, Dembinski A, Warzecha Z, Brzozowski T, Gregory H. Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Gastroenterology 1988; 94: 1300-7.
12. Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology 1994; 106: 1106-11.
13. Kobayashi K, Tominaga K, Kim S, Fukuda T, Higuchi K, Nakamura H, et al. Expression of genes for transforming growth factor-β1 and components of the extracellular matrix during gastric ulcer healing in rats. Gastroenterology 1994; 106: 108A.
14. Mustoe TA, Pierce GF, Thomson A, Gramates P, Sporn MB, Duel TF. Accelerated healing of incisional wound induced by transforming growth factor-β. Science 1987; 237: 1333-6.
15. Tamawski A, Stachura J, Krause WJ, Douglass TG, Gergely H. Quality of gastric ulcer healing: a new, emerging concept. J Clin Gastroenterol 1991; 13 (suppl 1): S42-7.
16. Mustoe TA, Landes A, Cromack DT. Differential acceleration of healing of surgical incisions in the rabbit gastrointestinal tract by platelet-derived growth factor and transforming growth factor, type β. Surgery 1990; 108: 324-30.