BRCAI gene mutations in sporadic ovarian carcinomas: Detection by PCR and reverse allele-specific oligonucleotide hybridization

Clinical Chemistry

Volumn 45, Issue 7, 1999, Pages 976-981

  Tong, Dan ^a   Stimpfl, Margit ^a   Reinthaller, Alexander ^a   Vavra, Norbert ^a   Müllauer Ertl, Silvia ^b   Leodolter, Sepp ^a,c   Zeillinger, Robert ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVARY CARCINOMA; OVARY METASTASIS; POLYMERASE CHAIN REACTION; UTERINE TUBE CARCINOMA; ALLELE; FEMALE; GENETICS; MUTATION; NUCLEIC ACID HYBRIDIZATION; OVARY TUMOR;

FALLOPIA;

BRCA1 PROTEIN; DNA;

ALLELES; BRCA1 PROTEIN; DNA, NEOPLASM; FEMALE; HUMANS; MUTATION; NUCLEIC ACID HYBRIDIZATION; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION;

EID: 0032586902     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/45.7.976     Document Type: Article

References (19)

1. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.
2. Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 1996;56:3168-72.
3. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997;88:265-75.
4. WAF1/CiPL. Nature 1997;389:187-90.
5. Zhang HB, Somasundaram K, Peng Y, Tian H, Zhang HX, Bi D, et al. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 1998;16:1713-21.
6. Easton DF, Bishop DT, Ford D, Crockford GP. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am J Hum Genet 1993;52:678-701.
7. Merajver SD, Pham TM, Caduff RF, Chen M, Poy EL, Cooney KA, et al. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. Nat Genet 1995;9:439-43.
8. Hosking L, Trowsdale J, Nicolai H, Solomon E, Foulkes W, Stamp G, et al. A somatic BRCA1 mutation in an ovarian tumour. Nat Genet 1995;9:343-4.
9. Papp J, Csokay B, Bosze P, Zalay Z, Toth J, Ponder B, Olah E. Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas. Br J Cancer 1996;74:1592-7.
10. Beckmann MW, Picard F, An HX, Van Roeyen CR, Dominik SI, Mosny DS, et al. Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer. Br J Cancer 1996;73:1220-6.
11. Roa BB, Boyd AA, Volcik K, Richards CS. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nat Genet 1996;14:185-7.
12. Matsushima M, Kobayashi K, Emi M, Saito H, Saito J, Suzumori K, Nakamura Y. Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation. Hum Mol Genet 1995;4:1953-6.
13. Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod S, Couch F, et al. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. JAMA 1995;273:535-41.
14. FitzGerald MG, MacDonald DJ, Krainer M, Hoover I, O'Neil E, Unsal H, et al. Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 1996;334:143-9.
15. Zhang Y, Coyne MY, Will SG, Levenson CH, Kawasaki ES. Single-base mutational analysis of cancer and genetic diseases using membrane bound modified oligonucleotides. Nucleic Acids Res 1991;19:3929-33.
16. Saiki RK, Walsh PS, Levenson CH, Erlich HA. Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A 1989;86:6230-4.
17. Serov SF, Scully RE, Sobin LH. Histological typing of ovarian tumours. International histological classification of tumours, No. 9. Geneva: World Health Organization, 1973.
18. Pere H, Tapper J, Seppälä M, Knuutila S, Butzow R. Genomic alterations in fallopian tube carcinoma: comparison to serous uterine and ovarian carcinomas reveals similarity suggesting likeness in molecular pathogenesis. Cancer Res 1998;58:4274-6.
19. Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King MC. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet 1994;8:399-404.