Dendritic signal integration

Current Opinion in Neurobiology

Volumn 7, Issue 3, 1997, Pages 385-390

  Eilers, Jens ^a   Konnerth, Arthur ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION;

ACTION POTENTIAL; CALCIUM CURRENT; DENDRITE; DENDRITIC SPINE; EXCITATION; IMAGING; LONG TERM POTENTIATION; PHOTON; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030858637     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(97)80067-0     Document Type: Article

References (55)

1. Ramón y Cajal S. Histology of the Nervous System of Man and Vertebrates. 1995;Oxford University Press, New York.
2. Llinás R, Sugimori M. Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J Physiol. 305:1980;197-213.
3. Yuste R, Tank DW. Dendritic integration in mammalian neurons, a century after Cajal. Neuron. 16:1996;701-716.
4. Koch C. Computation and the single neuron. Nature. 385:1997;207-210.
5. 2+ spikes were detected during the initial and later stages of cortical sensory processing. of special interest.
6. + APs. of outstanding interest.
7. Denk W, Yuste R, Svoboda K, Tank D. Imaging calcium dynamics in dendritic spines. Curr Opin Neurobiol. 6:1996;372-378.
8. 2+ channels, may serve to integrate local dendritic signals. of outstanding interest.
9. 2+ transients in individual spines of Purkinje cell dendrites. The results of this report support the view that individual spines constitutes the minimal neuronal integration compartment. of special interest.
10. Markram H, Sakmann B. Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels. Proc Natl Acad Sci USA. 91:1994;5207-5211.
11. 2+ transients produced by APs and EPSPs. of outstanding interest.
12. 2+ channels can be activated by subthreshold EPSPs. Dendritic voltage-gated channels are suggested to contribute to dendritic integration of synaptic signals. of special interest.
13. 2+ currents in distal dendrites. of special interest.
14. 2+ currents in dendritic recordings from Purkinje cells in rat cerebellar slice cultures. J Neurosci. 17:1997;160-170.
15. Hillman D, Chen S, Cherksey B, Sugimori M, Llinás RR. Localization of P-type calcium channels in the central nervous system. Proc Natl Acad Sci USA. 88:1991;7076-7080.
16. 2+ entry through the N-methyl-D-aspartate channel. Proc Natl Acad Sci USA. 91:1994;8170-8174.
17. 2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice. Neuron. 14:1995;1223-1231.
18. 2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones. J Physiol. 491:1996;757-772.
19. 2+ influx through AMPA receptor channels may regulate synaptic plasticity. of special interest.
20. Schneggenburger R, Zhou Z, Konnerth A, Neher E. Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron. 11:1993;133-143.
21. 2+ in neuronal signalling. Konnerth A, Tsien R, Mikoshiba K, Altman J. Coincidence Detection in the Nervous System. 1996;22-31 Human Frontier Science Program, Strasbourg.
22. Spacek J, Harris K. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J Neurosci. 17:1997;190-203 Thorough morphological study, indicating that morphologically distinct types of spines differ also in their content of smooth endoplasmic reticulum. These results suggest that the smooth endoplasmic reticulum regulates the function of a subpopulation of dendritic spines. of special interest.
23. Wang SS, Augustine GJ. Confocal imaging and local photolysis of caged compounds: dual probes of synaptic function. Neuron. 15:1995;755-760.
24. Batchelor A, Garthwaite J. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature. 385:1997;74-77 The authors present evidence for a new form of dendritic integration in cerebellar Purkinje cells. A single climbing fiber response was shown to promote, during a defined time window, the excitation by synaptic metabotropic glutamate receptors. of special interest.
25. 2+ release from intracellular stores induced by afferent stimulation of CA3 pyramidal neurons in hippocampal slices. J Neurophysiol. 76:1996;554-562.
26. Markram H, Helm J, Sakmann B. Dendritic calcium transients evoked by single back-propagating action potentials in rat neocortical pyramidal neurons. J Physiol. 485:1995;1-20.
27. Airaksinen MS, Eilers J, Garaschuck O, Thoenen H, Konnerth A, Meyer M. Ataxia and altered dendritic calcium signalling in mice carrying a targeted null mutation of the calbindin D28k gene. Proc Natl Acad Sci USA. 94:1997;1488-1493.
28. Spruston N, Schiller Y, Stuart G, Sakmann B. Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science. 268:1995;297-300.
29. Stuart G, Sakmann B. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature. 367:1994;69-72.
30. 2+ entry into hippocampal neurons. Nature. 357:1992;244-246.
31. Schiller J, Helmchen F, Sakmann B. Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones. J Physiol. 487:1995;583-600.
32. 2+ signals and induced LTP. of outstanding interest.
33. Larkum M, Rioult M, Lüscher H-R. Propagation of action potentials in the dendrites of neurons from rat spinal cord slice culture. J Neurophysiol. 75:1996;154-170.
34. 2+ concentration encodes the AP frequency during physiological activity. of special interest.
35. Bliss TVP, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
36. Artola A, Hensch T, Singer W. Calcium-induced long-term depression in the visual cortex of the rat in vitro. J Neurophysiol. 76:1996;984-994.
37. 2+ signaling requirements for long-term depression in the hippocampus. Neuron. 16:1996;825-833.
38. i needed to trigger LTD and LTP. Neuron. 16:1996;619-629.
39. Malenka R, Lancaster B, Zucker R. Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation. Neuron. 9:1992;121-128.
40. 2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus. Neuron. 9:1992;1175-1183.
41. Markram H, Lübke J, Frotscher M, Sakmann B. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science. 275:1997;213-215 Dual patch-clamp recordings from neighbouring neocortical neurons demonstrating surprisingly narrow time windows for the bidirectional regulation of synaptic strength. Pairing of unitary EPSPs with backpropagating APs induced a persistent potentiation or depression of the EPSP amplitude, depending on the sequence of activation. of outstanding interest.
42. Llano I, Marty A, Armstrong CM, Konnerth A. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J Physiol. 434:1991;183-213.
43. Stuart G, Häusser M. Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron. 13:1994;703-712.
44. Ito M. The cellular basis of cerebellar plasticity. Curr Opin Neurobiol. 1:1991;616-620.
45. Hartell N. Strong activation of parallel fibers produce localized calcium transients and a form of LTD that spreads to distant synapses. Neuron. 16:1996;601-610 The author reports that subthreshold synaptic activation of parallel fibers is sufficient to induce cerebellar LTD. He found two forms of TLD, one form that is insensitive to NO at directly activated synapses and one that is sensitive to NO at synapses that are not activated during the induction of LTD. of special interest.
46. 2+ transients. Neuron. 15:1995;407-415.
47. Hartell N. Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression. J Neurosci. 16:1996;2881-2890.
48. Linden D. A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron. 17:1996;483-490.
49. Buzsáki G, Penttonen M, Nádasdy Z, Bragin A. Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo. Proc Natl Acad Sci USA. 93:1996;9921-9925.
50. Miles R, Tóth K, Gulyás A, Hájos N, Freund T. Differences between somatic and dendritic inhibition in the hippocampus. Neuron. 16:1996;815-823.
51. 2+ signals occurring during strong synaptic excitation in Purkinje neurons. of special interest.
52. Svoboda K, Tank D, Denk W. Direct measurement of coupling between dendritic spines and shafts. Nature. 272:1996;716-719.
53. Durand G, Kovalchuk Y, Konnerth A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature. 381:1996;71-75.
54. Narasimhan K, Linden D. Defining a minimal computational unit for cerebellar long-term depression. Neuron. 17:1996;333-341.
55. Harris K, Kater S. Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Annu Rev Neurosci. 17:1994;341-371.