Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues

Acta Neurobiologiae Experimentalis

Volumn 56, Issue 1, 1996, Pages 287-298

  Marcinkiewicz, Mieczyslaw ^a   Seidah, Nabil G ^a   Chrétien, Michel ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

central and peripheral nervous system; endocrine system; furin; in situ hybridization; neuropeptides; neurotrophins; PC1; PC2; PC5; precursor processing; prohormone convertase

Indexed keywords

CARBAMAZEPINE; CONVERTASE; HORMONE PRECURSOR; NEUROPEPTIDE; NEUROTROPHIN; SUBTILISIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; BRAIN DEVELOPMENT; CONFERENCE PAPER; IN SITU HYBRIDIZATION; MAMMAL; NONHUMAN; RAT;

EID: 0029921584     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (61)

1. Beaubien G., Schäfer M.K.-H., Weihe E., Chrétien M., Seidah N.G., Day R. (1995) The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates. Cell Tissue Res. 279: 539-549.
2. Benjannet S., Rondeau N., Day R., Chrétien M., Seidah N.G. (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl. Acad. Sci. USA 88: 564-3568.
3. Benjannet S., Rondeau N., Paquet L., Boudreault A., Lazure C., Chrétien M., Seidah N.G. (1993) Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. Biochem. J. 294: 735-743.
4. Berkemeier L., Winslow J., Kaplan D., Nicolics K., Goeddel D., Rosenthal A. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7: 857-866.
5. Bresnahan P.A., Leduc R., Thomas L., Thorner J., Gibson H.L., Brake A.J., Barr P.J, Thomas G. (1990) Human fur gene encodes a yeast Kex2-like endoprotease that cleaves pro-β-NGF in vivo. J. Cell Biol. 111: 2851-2859.
6. Chrétien M., Benjannet S., Gossard F., Gianoulakis C., Crine P., Lis M., Seidah N.G. (1979) From β-lipotropin to β-endorphin and pro-opiomelanocortin. Can. J. Biochem. 57: 1111-1121.
7. Chrétien M., Li C.H. (1967) Isolation, purification and characterization of γlipotropic hormone from sheep pituitary glands. Can. J. Biochem. 45: 1163-1174.
8. Chrétien M., Benjannet S., Marcinkiewicz M, Day R., Seidah N.G. (1995) Role of convertases in the processing of neuropeptides and neurotrophins. Proceedings of 12th Int. Symposium on Neurosecretion 1995. Kiel, Germany, In: Advances in Life Sciences, Birkhäuser, Basel, in press.
9. David-Pfeuty T., Nouvian-Dooghe Y. (1990) Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells. J. Cell Biol. 111: 3097-3116.
10. Day R., Schäfer M.K.-H., Cullinan W.E., Watson S.J., Chrétien M., Seidah N.G. (1993) Region specific expression of furin mRNA in the rat brain. Neurosci Lett. 149: 27-30.
11. Day R., Schäfer M.K.-H., Watson S.J., Chrétien M., Seidah N.G (1992) Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Mol. Endocrinol. 6: 85-497.
12. Dong W., Marcinkiewicz M., Vieau D., Chrétien M., Seidah N.G., Day R. (1995) Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J. Neurosci. 15: 1778-1796.
13. Dupuy A., Lindberg I., Zhou Y., Akil H., Lazure C., Chrétien M., Seidah N.G., Day R. (1994) Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. FEBS Letters 337: 60-65.
14. Eipper B., May V., Cullen E.I., Sato S.M., Murthy A.S.N., Mains R.E. (1987) Cotranslational and posttranslational processing in the production of bioactive peptides. In: Psychopharmacology: the third generation of progress (Ed. H.Y. Meltzer). Raven Press, New York. p. 385-400.
15. Ernfors, P., Ibanez, C.F., Ebendal, T., Olson, L., Persson, H. (1990) Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc. Natl. Acad. Sci. USA 87: 454-5458.
16. Fuller R.S., Sterne R.E., Thorner J. (1988) Enzymes required for yeast prohormone processing. Annu. Rev. Physiol. 50: 345-362.
17. Galanopoulou A.S., Kent G., Rabbani S.N., Seidah N.G., Patel Y.C. (1993) Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. J. Biol. Chem. 268: 6041-6049.
18. Gee P., Rhodes C.H., Fricker L.D., Angeletti R.H. (1993) Expression of neuropeptide processing enzymes and neurosecretory proteins in ependyma and choroid plexus epithelium. Brain Res. 617: 238-248.
19. Gotz R., Koster R., Winkler C., Raulf F., Lottspelch F., Schartl M., Thoenen H. (1994) Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372: 266-269.
20. Hendy G.N., Bennett H.P., Gibbs B.F., Lazure C., Day R., Seidah N.G. (1995) Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. J. Biol. Chem. 270: 9517-25.
21. Hornby P.J., Rosenthal S.D., Mathis J.P., Vindrola O., Lindberg I. (1993) Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells. Neuroendocrinol. 58: 555-563.
22. Julius D., Brake A., Blair L., Kunisawa R., Thorner J. (1984) Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell 37: 1075-1089.
23. Kiefer M.C., Tucker J.E., Joh R., Landsberg K.E., Saltman D., Barr P.J. (1991) Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol. 10: 757-769.
24. Kurjan J., Herskowitz I. (1982) Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor. Cell 30: 933-43.
25. Lazure C., Seidah N.G., Pélaprat D., Chrétien M. (1983) Proteases and post-translational processing of prohormones: a review. Can. J. Biochem. Cell Biol. 61: 501-515.
26. Leibrock J., Lottspeich A.H., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.-A. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341: 149-152.
27. Lippincott-Schwartz J., Youan L.C., Bonifacino J.S., Klausner R.D. (1989) Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56: 801-813.
28. Lusson J., Vieau D., Hamelin J., Day R., Chrétien M., Seidah N.G. (1993) cDN A structure of mouse and rat PC5: a novel subtilisin/kexin-like pro-protein convertase expressed in endocrine and non-endocrine cells. Proc. Natl. Acad. Sci. USA 90: 6691-6695.
29. Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G. D. (1990) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247: 1446-1451.
30. Malide D., Seidah N.G., Chrétien M., Bendayan M. (1995) Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic β-cells. J. Histochem. Cytochem. 43: 11-19.
31. Marcinkiewicz M., Day R., Seidah N.G., Chrétien M. (1993b) Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and α-melanotropin. Proc. Natl. Acad. Sci.USA 90: 4922-4926.
32. Marcinkiewicz M., Nagao T., Avoli M., Day R., Seidah N.G., Chrétien M. (1994) Implication of prohormone convertases PC1, Furin and PC5 in the processing of NGF and BDNF precursors in rats with pilocarpine seizures. Soc. Neurosci. 20, Abstract 610.4.USA 90: 4922-4926.
33. Marcinkiewicz M., Ramla D., Seidah N.G., Chrétien M. (1994b) Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets. Endocrinology 135: 1651-1660.
34. Marcinkiewicz M., Seidah N.G., Chrétien M. (1993a) Les convertases des prohormones et le systčme nerveux. Médecine/Sciences 9: 553-561.
35. Molloy S.S., Thomas L., VanSlyke J.K., Sternberg P.E., Thomas G. (1994) Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J. 13: 18-33.
36. Nakagawa T., Hosaka M., Nakayama K. (1993) Identification of an isoform with an extremely large Cys-rich region of PC6, a kex-like processing endoprotease. FEBS Lett. 327: 165-171.
37. Nakagawa T., Hosaka M., Torij S., Watanabe T., Murakami K., Nakayama K. (1993) Identification of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. J. Biochem. 113: 132-135.
38. Nakayama K., Kim W.S., Torii S., Hosaka M., Nakagawa T., Ikemizu J., Baba T., Murakami K. (1992) Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease: its testis specific expression. J. Biol. Chem. 267: 5897-5900.
39. Roebroek A.J.M., Schalken J. A., Leunissen J.A.M., Onnekink H.P.J., Gloemers W.J.M., Van de Ven W.J.M. (1989) Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO J. 5: 2197-2202.
40. Schäfer M.K.-H., Day R., Cullinan, W.E., Chrétien M., Seidah N.G., Watson S.J. (1993) Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis. J. Neurosci. 13: 1258-1279.
41. Scopsi L., Gullo M., Rilke F., Martin S., Steiner D. (1995) Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. J. Clin. Endocrinol. Metabol. 80: 2294-301.
42. Scott J., Selby M., Urdea M., Quiroga M., Bell G.I., Rutter W.I. (1983) Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature 302: 538-540.
43. Seidah N.G. (1995) The mammalian family of subtilisin/kexin-like pro-protein convertases. In: Intramolecular chaprones and protein folding (Eds. U. Shinde and M. Inoye). R.G. Landes Cie, Austin, TX p. 187-203
44. Seidah N.G., Benjannet S., Pareek S., Savaria D., Hamelin I., Laliberté J., Lazure C., Chrétien M., Murphy R.A. (1995) Cellular processing of the NGF, BDNF and NT3 precursors by the mammalian pro-protein convertases. Biochem. J. (in press)
45. Seidah N.G., Day R., Chrétien M. (1993) The family of prohormone and pro-protein convertases. Biochem. Soc. Trans. 21: 685-691.
46. Seidah N.G., Day R., Hamelin J., Gaspar A., Collard M.W., Chrétien M. (1992) Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Mol. Endocrinol. 6: 1559-1570.
47. Seidah N.G., Gaspar L., Mion P., Marcinkiewicz M., Mbikay M., Chrétien M. (1990) cDNA sequence of two distinct pituitary proteins homologous to Kex2 and Furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell. Biol. 6: 415-424.
48. Seidah N.G., Hamelin J., Mamarbachi M., Dong W., Tadros H., Mbikay M., Chrétien M., Day R. (1996) CDNA structure, tissue distribution and chromosomal localization of rat PC7: a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. USA (in press)
49. Seidah N.G., Marcinkiewicz M., Benjannet S., Gaspar L., Beaubien G., Mattei M.G., Lazure C., Mbikay M., Chrétien M. (1991) Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol. Endocrinol. 5: 111-122.
50. Seidah N.G., Pareek S., Benjannet S., Laliberté J., Chrétien M., Murphy R.A. (1994) Processing of NGF, BDNF and NT-3 precursors by prohormone convertases. Society for Neuroscience, 24th Annual Meeting, Miami Beach, Florida, November 13-18, Abstract 538.9.
51. Smeekens S.P., Steiner D.F. (1990) Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J. Biol. Chem. 265: 2997-3000.
52. Smeekens S.P., Avruch A.S., LaMendola J., Chan S.J., Steiner D.F. (1991) Identification of cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc. Natl. Acad. Sci. USA 88: 340-344.
53. Smeekens S.P., Montag A.G. Thomas G. Albiges-Rizo C., Carrol R., Benig M., Phillips L.A., Martin S., Ohagi S., Gardner P., Swift H.H., Steiner D.F. (1992) Proinsulin processing by the subtilisin-rclated proprotein convertases furin, PC2 and PC3. Proc. Natl. Acad.Sci. USA 89: 8822-8826.
54. Steiner D.F., Cunningham D., Spiegelman L., Aten B. (1967) Insulin biosynthesis: evidence for a precursor. Science 157: 697-700.
55. Steiner D.F., Smeekens S.P., Ohagi S., Chan S.J. (1992) The new enzymology of precursor processing endoproteases. J. Biol. Chem. 267: 23435-23438.
56. Tanaka S., Nomizu M., Kurosumi K. (1991) Intracellular sites of proteolytic processing of pro-opiomelanocortin in melanotrophs and corticotrophs in rat pituitary. J. Histochem Cytochem. 39: 809-821.
57. Thomas L., Leduc R., Thorne B.A., Smeekens S.P., Steiner D.F., Thomas G. (1991) Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Proc. Natl. Acad. Sci. USA 88: 5297-5301.
58. Van de Ven W.J.M., Roebroek A. (1993) Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases. Crit. Rev. Oncog. 4: 115-136.
59. Virtanen I., Ekblom P., Laurila P. (1980) Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cells. J. Cell Biol. 85: 429-434.
60. Xu H., Shields D. (1993) Prohormone processing in the transGolgi network: endoproteolytic cleavage of prosomatostatin and formation nascent secretory vesicles in permeabilized cells. J. Cell Biol. 122: 1169-1184.
61. Zheng M., Streck R.D., Scott R.E., Seidah N.G., Pintar J.E (1994). The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity. J. Neurosci. 14: 4656-4673.