Proopiomelanocortin (POMC) mRNA expression: Distribution and region-specific down-regulation by chronic morphine in female guinea pig hypothalamus

Molecular Brain Research

Volumn 55, Issue 1, 1998, Pages 1-8

  Fang, Yuan ^a,b   Kelly, Martin J ^a   Rønnekleiv, Oline K ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

endorphin; Arcuate nucleus; Female guinea pig; In situ hybridization histochemistry; Median eminence; Morphine pellet

Indexed keywords

BETA ENDORPHIN; BRAIN PROTEIN; ENDORPHIN; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; PROOPIOMELANOCORTIN; SULFUR 35;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; AUTORADIOGRAPHY; BIOSYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GUINEA PIG; HISTOCHEMISTRY; HYPOTHALAMUS; IN SITU HYBRIDIZATION; ISOTOPE LABELING; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SILVER STAINING; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ARCUATE NUCLEUS; BETA-ENDORPHIN; DEPRESSION, CHEMICAL; DRUG IMPLANTS; DRUG TOLERANCE; FEEDBACK; FEMALE; GENE EXPRESSION REGULATION; GUINEA PIGS; HYPOTHALAMUS; HYPOTHALAMUS, MIDDLE; IN SITU HYBRIDIZATION; MEDIAN EMINENCE; MORPHINE; NEURONS; OVARIECTOMY; PRO-OPIOMELANOCORTIN; RECEPTORS, OPIOID, MU; RNA, MESSENGER;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0032579762     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00348-3     Document Type: Article

References (69)

1. D.J. Autelitano, M. Blum, M. Lopingco, R.G. Allen, J.L. Roberts, Corticotropin-releasing factor differentially regulates anterior and intermediate pituitary lobe proopiomelanocortin gene transcription, nuclear precursor RNA and mature mRNA in vivo, Neuroendo. 51 (1990) 123-130.
2. R.A. Baker, W.J. Shoemaker, Effect of prenatal ethanol and stress on levels of β-endorphin in different brain regions of the rat, Alcoholism: Clin. Exp. Res. 19 (1995) 727-734.
3. J.V. Bartolome, M.B. Bartolome, B.A. Lorber, S.J. Dileo, S.M. Schanberg, Effects of central administration of beta-endorphin on brain and liver DNA synthesis in preweanling rats, Neuroscience 40 (1991) 289-294.
4. V. Baubet, M. Fevre-Montange, N. Gay, G. Debilly, P. Bobillier, R. Cespuglio, Effects of an acute immobilization stress upon proopiomelanocortin (POMC) mRNA levels in the mediobasal hypothalamus: a quantitative in situ hybridization study, Mol. Brain Res. 26 (1994) 163-168.
5. R. Bleier, The Hypothalamus of the Guinea Pig: A Cytoarchitectonic Atlas, University of Wisconsin Press, Madison, 1983.
6. B. Bloch, C. Bugnon, D. Fellman, D. Lenys, Immunocytochemical evidence that the same neuron in the human infundibular nucleus are stained with anti-endorphins and antisera of other related peptides, Neurosci. Lett. 10 (1978) 147-152.
7. F.E. Bloom, E. Battenberg, J. Rossier, N. Ling, R. Guillemin, Neurons containing β-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies, Proc. Natl. Acad. Sci. USA 75 (1978) 1591-1595.
8. A.F. Bradbury, D.G. Smyth, C.R. Snell, N.J.M. Birdsall, E.C. Hulme, C fragment of lipotropin has a high affinity for brain opiate receptors, Nature 260 (1976) 793-795.
9. D.M. Bronstein, H. Akil, In vitro release of hypothalamic β-endorphin (βE) by arginine vasopressin, corticotropin-releasing hormone and 5-hydroxytryptamine: evidence for release of opioid active and inactive βE forms, Neuropeptides 16 (1990) 33-40.
10. D.M. Bronstein, N.C. Day, H.B. Gutstein, K.A. Trujillo, H. Akil, Pre- and post-translational regulation of β-endorphin biosynthesis in the CNS: effects of chronic naltrexone treatment, J. Neurochem. 60 (1993) 40-49.
11. D.M. Bronstein, R. Przewlocki, H. Akil, Effects of morphine treatment on pro-opiomelanocortin systems in the rat brain, Brain Res. 519(1990) 102-111.
12. D.M. Bronstein, M.K.-H. Schafer, S.J. Watson, H. Akil, Evidence that β-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA, Brain Res. 587 (1992) 269-275.
13. C. Chavkin, A. Goldstein, Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus, Proc. Natl. Acad. Sci. USA 81 (1984) 7253-7257.
14. W.-P. Chen, J.W. Witkin, A.J. Silverman, β-endorphin and gonadotropin-releasing hormone synaptic input to gonadotropin-releasing hormone neurosecretory cells in the male rat, J. Comp. Neurol. 286 (1989) 85-95.
15. J.A. Chowen-Breed, D.K. Clifton, R.A. Steiner, Regional specificity of testosterone regulation of proopiomelancortin gene expression in the arcuate nucleus of the male rat brain, Endo. 124 (1997) 2875-2881.
16. B.M. Cox, K.E. Opheim, H. Teschemacher, A. Goldstein, A peptide-like substance from pituitary that acts like morphine: 2. Purification and properties, Life Sci. 16 (1975) 1777-1782.
17. N. De Pedro, M.V. Cespedes, M.J. Delgado, M. Alonso-Bedate, Mu-opioid receptor is involved in β-endorphin-induced feeding in goldfish, Peptides 17 (1996) 421-424.
18. D. de Wied, J. Jolles, Neuropeptides derived from pro-opiocortin: behavioral, physiological and neurochemical affects, Physiol. Rev. 62 (1982) 976-1059.
19. C. Decavel, A.N. Van den Pol, GABA: A dominant neurotransmitter in the hypothalamus, J. Comp. Neurol. 302 (1990) 1019-1037.
20. G. Di Chiara, R.A. North, Neurobiology of opiate abuse, Trends Pharm. Sci. 13 (1992) 185-193.
21. Y. Fang, M.J. Kelly, D.K. Grandy, O.K. Rönnekleiv, Proopiomelanocortin and mu opioid receptor mRNA expression in the female guinea pig hypothalamus: effects of chronic morphine treatment, Soc. Neurosci. Abstr. 21 (1995) 1355.
22. J.C.W. Finley, P. Lindstrom, P. Petrusz, Immunocytochemical localization of β-endorphin- containing neurons in the rat brain, Neuroendo. 33 (1981) 28-42.
23. E. Garcia de Yebenes, G. Pelletier, Opioid regulation of proopiomelanocortin (POMC) gene expression in the rat brain as studied by in situ hybridization, Neuropeptides 25 (1993) 91-94.
24. C.E. Gee, C.C. Chen, J.L. Roberts, R. Thompson, S.J. Watson, Identification of proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization, Nature 306 (1983) 374-376.
25. C. Gianoulakis, Implications of endogenous opioids and dopamine in alcoholism: human and basic science studies, Alcohol and Alcoholism 31 (1) (1996) 33-42.
26. C. Gianoulakis, J. Drouin, N.G. Seidah, H. Kalant, M. Chretien, Effect of chronic morphine treatment on β-endorphin biosynthesis by the rat neurointermediate lobe, Eur. J. Pharmacol. 72 (1981) 313-321.
27. P.C. Goldsmith, J.E. Boggan, K.K. Thind, Opioid synapses on vasopressin neurons in the paraventricular and supraoptic nuclei of juvenile monkeys, Neuroscience 45 (1991) 709-719.
28. A. Goldstein, R. Schulz, Morphine-tolerant longitudinal muscle strip from guinea-pig ileum, Br. J. Pharmacol. 48 (1973) 655-666.
29. M. Harbuz, J.A. Russell, B.E.H. Sumner, M. Kawata, S.L. Lightman, Rapid changes in the content of proenkephalin A and corticotrophin releasing hormone mRNAs in the paraventricular nucleus during morphine withdrawal in urethane-anaesthetized rats., Mol. Brain Res. 9 (1991) 285-291.
30. Y. Ibata, F. Kawakami, H. Okamura, H.L. Obata-Tsuto, N. Morimoto, E.A. Zimmerman, Light and electron microscope immunocytochemistry of β-endorphin/ β-LPH-like immunoreactive neurons in the arcuate nucleus and surrounding areas of the rat hypothalamus, Brain Res. 341 (1985) 233-242.
31. K. Ishikawa, K. Katakai, S. Tanaka, S. Haga, H. Mochida, K. Itoh, Pro-opiomelanocortin-containing neurons in rat median eminence, Neuroendo. 56 (1992) 178-184.
32. S.B. Jaffe, S. Sobieszczyk, S.L. Wardlaw, Effect of opioid antagonism on β-endorphin processing and proopiomelanocortin-peptide release in the hypothalamus, Brain Res. 648 (1994) 24-31.
33. S.A. Joseph, W.H. Pilcher, C. Bennett-Clarke, Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system, Neurosci. Lett. 38 (1983) 221-225.
34. M.-C. Keightley, J.W. Funder, P.J. Fuller, Molecular cloning and sequencing of a guinea-pig pro-opiomelanocortin cDNA, Mol. Cell Endocrinol. 82 (1991) 89-98.
35. M.J. Kelly, M.D. Loose, O.K. Rönnekleiv, Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance, Neuroendo. 52 (1990) 268-275.
36. H. Khachaturian, M.E. Lewis, S.N. Haber, H. Akil, S.J. Watson, Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain, Brain Res. Bull. 13 (1984) 785-800.
37. G.F. Koob, Drugs of abuse: anatomy, pharmacology and function of reward pathways, Trends Pharm. Sci. 13 (1992) 177-184.
38. G.F. Koob, F.E. Bloom, Behavioural effects of opioid peptides, Br. Med. Bull. 39 (1) (1983) 89-94.
39. H.W. Kosterlitz, J. Hughes, Some thoughts on the significance of enkephalin, the endogenous ligand, Life Sci. 17 (1) (1975) 91-96.
40. A.H. Lagrange, O.K. Rönnekleiv, M.J. Kelly, Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A, Mol. Pharmacol. 51 (1997) 605-612.
41. A.H. Lagrange, O.K. Rönnekleiv, M.J. Kelly, The potency of μ-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17β-estradiol, J. Neurosci. 14 (1994) 6196-6204.
42. B response in hypothalamic neurons, Neuroendo. 64 (1996) 114-123.
43. N. Levin, M. Blum, J.L. Roberts, Modulation of basal and corticotropin-releasing factor-stimulated proopiomelanocortin gene expression by vasopressin in rat anterior pituitary, Endo. 125 (1989) 2957-2966.
44. C.H. Li, D. Chung, Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands, Proc. Natl. Acad. Sci. USA 73 (1976) 1145-1148.
45. S.L. Lightman, W.S. Young III, Corticotrophin-releasing factor, vasopressin and pro-opiomelanocortin mRNA responses to stress and opiates in the rat, J. Physiol. 403 (1988) 511-523.
46. M.D. Loose, M.J. Kelly, Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance, Brain Res. 513 (1990) 15-23.
47. B and μ-opioid receptor agonists: evidence for convergence at a ligand-gated potassium conductance, Neuroendo. 54 (1991) 537-544.
48. I. Mocchetti, E. Costa, Down regulation of hypothalamic proopiomelanocortin system during morphine tolerance, Clin. Neuropharmacol. 9 (4) (1986) 125-127.
49. I. Mocchetti, A. Ritter, E. Costa, Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats, J. Mol. Neurosci. 1 (1989) 33-38.
50. J.I. Morrell, K.P. Corodimas, L.L. DonCarlos, C.A. Lisciotto, Axonal projections of gonadal steroid receptor-containing neurons, Neuroprotocols 1 (1992) 4-15.
51. J.I. Morrell, J.F. McGinty, D.W. Pfaff, A subset of β-endorphin or dynorphin-containing neurons in the medial basal hypothalamus accumulates estradiol, Neuroendo. 41 (1985) 417-426.
52. S. Nakanishi, A. Inoue, T. Kita, M. Nakamura, A.C.Y. Chang, S.N. Cohen, S. Numa, Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor, Nature 278 (1979) 423-427.
53. K.E. Nikolarakis, O.F.X. Almeida, A. Herz, Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro), Brain Res. 399 (1986) 152-155.
54. K.E. Nikolarakis, O.F.X. Almeida, A. Herz, Feedback inhibition of opioid peptide release in the hypothalamus of the rat, Neuroscience 23 (1) (1987) 143-148.
55. K.E. Nikolarakis, O.F.X. Almeida, D.J.S. Sirinathsinghji, A. Herz, Concomitant changes in the in vitro and in vivo release of opioid peptides and luteinzing hormone-releasing hormone from the hypothalamus following blockade of receptors for corticotropin-releasing factor., Neuroendocriology 47 (1988) 545-550.
56. J.K. Rao, H. Hu, C. Prasad, A. Jayaraman, The distribution pattern of adrenocorticotropin-like immunoreactivity in the cat central nervous system, Neurosci. Lett. 71 (1986) 48-52.
57. O.K. Rönnekleiv, M.A. Bosch, M.J. Cunningham, E.J. Wagner, D.K. Grandy, M.J. Kelly, Down regulation of μ-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment, Neurosci. Lett. 216 (1996) 129-132.
58. O.K. Rönnekleiv, M.A. Bosch, B.R. Naylor, M.J. Kelly, Progonadotropin-releasing hormone synthesis and processing: measurements of mRNA and peptides, in: P.M. Conn (Ed.), Methods in Neurosciences; Neuropeptide Technology; Gene Expression and Neuropeptide Receptors, Academic Press, 1991, pp. 85-108.
59. O.K. Rönnekleiv, B.R. Naylor, C.T. Bond, J.P. Adelman, Combined immunohistochemistry for gonadotropin-releasing hormone (GnRH) and pro-GnRH, and in situ hybridization for GnRH messenger ribonucleic acid in rat brain, Mol. Endo. 3 (1989) 363-371.
60. D.J. Smith, B. Robertson, P.J. Monroe, D.A. Taylor, J.A. Leedham, J.D.Y. Cabral, opioid receptors mediating antinociception from β-endorphin and morphine in the periaqueductal gray, Neuropharmacology 31 (1992) 1137-1150.
61. T. Suda, Y. Nakano, F. Tozawa, T. Sumitomo, Y. Sato, M. Yamada, H. Demura, The role of corticotropin-releasing factor and vasopressin in hypoglycemia-induced proopiomelanocortin gene expression in the rat anterior pituitary gland, Brain Res. 579 (1992) 303-308.
62. T. Suda, Y. Sato, T. Sumitomo, Y. Nakano, F. Tozawa, I. Iwai, M. Yamada, H. Demura, β-endorphin inhibits hypoglycimia-induced gene expression of corticotropin-releasing factor in the rat hypothalamus, Endo. 130 (1992) 1325-1330.
63. J.A. ten Haaf, T.B. Van Wimersma Greidanus, C. Maigret, D. de Wied, Effects the opioid peptide beta-endorphin on the in vivo release of vasopressin in rats under various conditions, Neuroendo. 44 (1986) 102-107.
64. H. Teschemacher, K.E. Opheim, B.M. Cox, A. Goldstein, A peptide-like substance from pituitary that acts like morphine: 1. Isolation, Life Sci. 16 (1975) 1771-1776.
65. J.E. Thornton, M.D. Loose, M.J. Kelly, O.K. Rönnekleiv, Effects of estrogen on the number of neurons expressing β-endorphin in the medial basal hypothalamus of the female guinea pig, J. Comp. Neurol. 341 (1994) 68-77.
66. L.F. Tseng, K.A. Collins, P.S. Portoghese, Spinal δ2 but not δ1 opioid receptors are involved in intracerebroventricular β-endorphin-induced antinociception in the mouse, Life Sci. 52 (1993) 211-215.
67. S.L. Wardlaw, J. Kim, S. Sobieszczyk, Effects of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus, Mol. Brain Res. 41 (1996) 140-147.
68. S.J. Watson, H. Akil, C.W. Richard III, J.D. Barchas, Evidence for two separate opiate peptide neuronal systems, Nature 275 (1978) 226-228.
69. G. Zhang, A.H. Lagrange, O.K. Rönnekleiv, M.J. Kelly, Tolerance of hypothalamic β-endorphin neurons to μ-opioid receptor activation following chronic morphine, J. Pharm. Exp. Ther. 277 (1996) 551-558.