Induction of apoptosis in colonic epithelium treated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its modulation by a P4501A2 inducer, β-naphthoflavone, in male F344 rats

Cancer Letters

Volumn 123, Issue 2, 1998, Pages 167-172

  Hirose, Yoshinobu ^a   Sugie, Shigeyuki ^a   Yoshimi, Naoki ^a   Matsunaga, Kengo ^a   Hara, Akira ^a   Mori, Hideki ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

naphthoflavone; 2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine (PhIP); Apoptosis

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; BETA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; ENZYME INDUCING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BETA-NAPHTHOFLAVONE; CARCINOGENS; COLON; ENZYME INHIBITORS; IMIDAZOLES; INTESTINAL MUCOSA; MALE; RATS; RATS, INBRED F344;

ANIMALIA; RODENTIA;

EID: 0032579199     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00413-8     Document Type: Article

References (27)

1. Sugimura T., Sato S. Mutagens-carcinogens in foods. Cancer Res. 43(Suppl.):1983;2415s-2421s.
2. Felton J.S., Knize M.G., Shen N.H., Lewis P.R., Andresen B.D., Happe J., Hatch F.T. The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 7:1986;1081-1086.
3. Ito N., Hasegawa R., Sano M., Tamano S., Esumi H., Takayama S., Sugimura T. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 12:1991;1503-1506.
4. Shirai T., Sano M., Tamano S., Takahashi S., Hirose M., Futakuchi M., Hasegawa R., Imaida K., Matsumoto K., Wakabayashi K., Sugimura T., Ito N. The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res. 57:1997;195-198.
5. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66:1981;1192-1208.
6. Wynder E.L., Fujita Y., Harris R.E., Hirayama T., Hiyama T. Comparative epidemiology of cancer between the United States and Japan. Cancer. 67:1991;746-763.
7. Turesky R.J., Lang N.P., Butler M.A., Teitel C.H., Kadlubar F.F. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis. 12:1991;1839-1845.
8. Ochiai M., Watanabe M., Kushida H., Wakabayashi K., Sugimura T., Nagao M. DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis. 17:1996;95-98.
9. Hammons G.J., Milton D., Stepps K., Guengerich F.P., Tukey R.H., Kadlubar F.F. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 18:1997;851-854.
10. Takayama K., Yamashita K., Wakabayashi K., Sugimura T., Nagao M. DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats. Jpn. J. Cancer Res. 80:1989;1145-1148.
11. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis: its significance in cancer and cancer therapy. Cancer. 73:1994;2013-2026.
12. Cerutti P.A. Oxidant stress and carcinogenesis. Eur. J. Clin. Invest. 21:1991;1-5.
13. Statland B.E. Nutrition and cancer. Clin. Chem. 38:1992;1587-1594.
14. Gordon L.I., Weitzman S.A. Inflammation and cancer. Cancer J. 6:1993;257-261.
15. Lane D.P. p53, guardian of the genome. Nature. 358:1992;15-16.
16. Hirose Y., Yoshimi N., Makita H., Hara A., Tanaka T., Mori H. Early alterations of apoptosis and cell proliferation in azoxymethane-initiated rat colonic epithelium. Jpn. J. Cancer Res. 87:1996;575-582.
17. Wargovich M.J., Goldberg M.T., Newmark H.L., Bruce W.R. Nuclear aberrations as a short-term test for genotoxicity to the colon: evaluation of nineteen agents in mice. J. Natl. Cancer Inst. 71:1983;133-137.
18. Sumiyoshi H., Wargovich M.J. Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res. 50:1990;5084-5087.
19. Lee H., Wang H.W., Su H.Y., Hao N.J. The structure-activity relationships of flavonoids as inhibitors of cytochrome P-450 enzymes in rat liver microsomes and the mutagenicity of 2-amino-3-methyl-imidazo[4,5-f]quinoline. Mutagenesis. 9:1994;101-106.
20. Ino N., Sugie S., Ohnishi M., Mori H. Lack of inhibitory effect of benzyl isothiocyanate on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats. J. Toxicol. Sci. 21:1996;189-194.
21. Potten C.S., Li Y.Q., O'Connor P.J., Winton D.J. A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis. 13:1992;2305-2312.
22. Hirose Y., Tanaka T., Makita H., Yang M., Satoh K., Hara A., Maeda M., Baba-Toriyama H., Mori H., Tsuda H. Suppressing effects of 6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine and related synthetic compounds on azoxymethane-induced aberrant crypt foci in rat colon. Jpn. J. Cancer Res. 87:1996;549-554.
23. Ward J.M. Dose response to a single injection of azoxymethane in rats. Vet. Pathol. 12:1975;165-177.
24. Isaacs J.T. Role of programmed cell death in carcinogenesis. Environ. Health Perspect. 101(Suppl. 5):1993;27-34.
25. Samaha H.S., Kelloff G.J., Steele V., Rao C.V., Reddy B.S. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 57:1997;1301-1305.
26. Madle S., Dean S.W., Andrae U., Brambilla G., Burlinson B., Doolittle D.J., Furihata C., Hertner T., McQueen C.A., Mori H. Recommendations for the performance of UDS tests in vitro and in vivo. Mutat. Res. 312:1994;263-285.
27. Josephy P.D., Gruz P., Nohmi T. Recent advances in the construction of bacterial genotoxicity assays. Mutat. Res. 386:1997;1-23.