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Volumn 353, Issue 1370, 1998, Pages 839-845

Epithelial carcinogenesis in the mouse: Correlating the genetics and the biology

Author keywords

Carcinogenesis; Invasion; Mouse; Skin; Stem cells; TGF

Indexed keywords

ANIMALIA;

EID: 0032578039     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1998.0248     Document Type: Article
Times cited : (30)

References (72)
  • 1
    • 0025041030 scopus 로고
    • Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter
    • Bailleul, B., Surani, M. A.,White, S., Barton, S. C., Brown, K., Blessing, M., Jorcano, J. & Balmain, A. 1990 Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell 62, 697-708.
    • (1990) Cell , vol.62 , pp. 697-708
    • Bailleul, B.1    Surani, M.A.2    White, S.3    Barton, S.C.4    Brown, K.5    Blessing, M.6    Jorcano, J.7    Balmain, A.8
  • 2
    • 0024383791 scopus 로고
    • Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
    • Behrens, J., Marcel, M. M., Van Roy, F. M. & Birchmeier, W. 1989 Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol. 108, 2435-2447.
    • (1989) J. Cell Biol. , vol.108 , pp. 2435-2447
    • Behrens, J.1    Marcel, M.M.2    Van Roy, F.M.3    Birchmeier, W.4
  • 3
    • 0025052266 scopus 로고
    • Non-random duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumours
    • Bianchi, A. B., Aldaz, C. M. & Conti, G. J. 1990 Non-random duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumours. Proc. Natn. Acad. Sci. USA 87, 6902-6906.
    • (1990) Proc. Natn. Acad. Sci. USA , vol.87 , pp. 6902-6906
    • Bianchi, A.B.1    Aldaz, C.M.2    Conti, G.J.3
  • 5
    • 0011493380 scopus 로고
    • Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons
    • Bizub, D., Wood, A. W. & Skalka, A. M. 1986 Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc. Natn. Acad. Sci. USA 83, 6048-6052.
    • (1986) Proc. Natn. Acad. Sci. USA , vol.83 , pp. 6048-6052
    • Bizub, D.1    Wood, A.W.2    Skalka, A.M.3
  • 6
    • 0025365140 scopus 로고
    • Genetic changes in skin tumour progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    • Bremner, R. & Balmain, A. 1990 Genetic changes in skin tumour progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407-417.
    • (1990) Cell , vol.61 , pp. 407-417
    • Bremner, R.1    Balmain, A.2
  • 7
    • 0028138796 scopus 로고
    • Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumours
    • Bremner, R., Kemp, C. J. & Balmain, A. 1994 Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumours, Molec. Carcinog. 11, 90-97.
    • (1994) Molec. Carcinog. , vol.11 , pp. 90-97
    • Bremner, R.1    Kemp, C.J.2    Balmain, A.3
  • 8
    • 0025038030 scopus 로고
    • Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumour progression
    • Brown, K., Buchmann, A. & Balmain, A. 1990 Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumour progression. Proc. Natn. Acad. Sci USA 87, 538-542.
    • (1990) Proc. Natn. Acad. Sci USA , vol.87 , pp. 538-542
    • Brown, K.1    Buchmann, A.2    Balmain, A.3
  • 10
    • 0026385870 scopus 로고
    • Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7
    • Buchmann, A., Ruggeri, B., Klein-Szanto, A. J. P. & Balmain, A. 1991 Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res. 51, 4097-4101.
    • (1991) Cancer Res. , vol.51 , pp. 4097-4101
    • Buchmann, A.1    Ruggeri, B.2    Klein-Szanto, A.J.P.3    Balmain, A.4
  • 11
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelics, C., Helmberg, A. & Karin, M. 1994 p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelics, C.1    Helmberg, A.2    Karin, M.3
  • 12
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns, J. 1975 Mutation selection and the natural history of cancer. Nature 255, 197-200.
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 13
    • 0029101527 scopus 로고
    • Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-βl induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype
    • Caulin, C., Scholl, F. G., Frontelo, P., Gamallo, C. & Quintanilla, M. 1995 Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-βl induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ. 6, 1027-1035.
    • (1995) Cell Growth Differ. , vol.6 , pp. 1027-1035
    • Caulin, C.1    Scholl, F.G.2    Frontelo, P.3    Gamallo, C.4    Quintanilla, M.5
  • 15
    • 0028301094 scopus 로고
    • p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
    • Clarke, A. R., Gledhill, S., Hooper, M. L., Bird, C. C. & Wyllie, A. H. 1994 p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 9, 1767-1773.
    • (1994) Oncogene , vol.9 , pp. 1767-1773
    • Clarke, A.R.1    Gledhill, S.2    Hooper, M.L.3    Bird, C.C.4    Wyllie, A.H.5
  • 16
    • 0030598681 scopus 로고    scopus 로고
    • TGFbeta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui, W, Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A. & Akhurst, R. J. 1996 TGFbeta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86, 531-542.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6    Akhurst, R.J.7
  • 17
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron, K. M., Volpert, O. V.,Tainsky, M. A. & Bouck, N. 1994 Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265, 1582-1584.
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 19
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W. & Giaccia, A. J. 1996 Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 20
    • 0029782220 scopus 로고    scopus 로고
    • Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha
    • Greenhalgh, D. A., Wang, X. J., Donehower, L. A. & Roop, D. R. 1996 Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res. 56, 4413-1423.
    • (1996) Cancer Res. , vol.56 , pp. 4413-11423
    • Greenhalgh, D.A.1    Wang, X.J.2    Donehower, L.A.3    Roop, D.R.4
  • 21
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclindependent kinases, and Cdk inhibitors in human cancer
    • Hall, M. & Peters, G. 1996 Genetic alterations of cyclins, cyclindependent kinases, and Cdk inhibitors in human cancer. Adv. Cancer Res. 68, 67-108.
    • (1996) Adv. Cancer Res. , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 22
    • 0024425529 scopus 로고
    • Stem cells: The generation and maintenance of cellular diversity
    • Hall, P. A. & Watt, F. M. 1989 Stem cells: the generation and maintenance of cellular diversity. Development 106, 619-633.
    • (1989) Development , vol.106 , pp. 619-633
    • Hall, P.A.1    Watt, F.M.2
  • 23
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon, G. J. & Beach, D. 1994 p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371, 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 24
    • 0001520752 scopus 로고
    • Epithelial-mesenchymal transitions
    • Hay, E. D. 1990 Epithelial-mesenchymal transitions. Devl Biol. 1, 347-356.
    • (1990) Devl Biol. , vol.1 , pp. 347-356
    • Hay, E.D.1
  • 25
    • 0040433650 scopus 로고
    • Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene
    • Hirakawa.T. & Ruley, H. E. 1988 Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proc. Natn. Acad. Sci. USA 85, 1519-1523.
    • (1988) Proc. Natn. Acad. Sci. USA , vol.85 , pp. 1519-1523
    • Hirakawa, T.1    Ruley, H.E.2
  • 29
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp, C. J., Donehower, L. A., Bradley, A. & Balmain, A. 1993a Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822.
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.J.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 30
    • 0027145128 scopus 로고
    • Allelotype analysis of mouse skin tumours using polymorphic microsatellites: Sequential genetic alterations on chromosomes 6, 7 and 11
    • Kemp, C. J., Fee, F. & Balmain, A. 1993b Allelotype analysis of mouse skin tumours using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7 and 11. Cancer Res. 53, 6022-6027.
    • (1993) Cancer Res. , vol.53 , pp. 6022-6027
    • Kemp, C.J.1    Fee, F.2    Balmain, A.3
  • 31
    • 0027504088 scopus 로고
    • Antioncogenes and human cancer
    • Knudson, A. G. 1993 Antioncogenes and human cancer. Proc. Natn. Acad. Sci. USA 90, 10 914-10 921.
    • (1993) Proc. Natn. Acad. Sci. USA , vol.90 , pp. 10914-10921
    • Knudson, A.G.1
  • 32
    • 0025970229 scopus 로고
    • D11S287, a putative oncogene on chromosome 11q1S, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1
    • Lammie, G. A., Fantl, V, Smith, R., Schuuring, E., Brookes, S., Michalides, R., Dickson, C., Arnold, A. & Peters, G. 1991 D11S287, a putative oncogene on chromosome 11q1S, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1. Oncogene 6, 439-444.
    • (1991) Oncogene , vol.6 , pp. 439-444
    • Lammie, G.A.1    Fantl, V.2    Smith, R.3    Schuuring, E.4    Brookes, S.5    Michalides, R.6    Dickson, C.7    Arnold, A.8    Peters, G.9
  • 33
    • 0029814061 scopus 로고    scopus 로고
    • Anti-apoptotic activity oflow levels of wild-type p53
    • Lassus, P., Ferlin, M., Piette, J. & Hibner, U. 1996 Anti-apoptotic activity oflow levels of wild-type p53. EMBO J. 15,4566-4573.
    • (1996) EMBO J. , vol.15 , pp. 4566-4573
    • Lassus, P.1    Ferlin, M.2    Piette, J.3    Hibner, U.4
  • 34
    • 0024281617 scopus 로고
    • Inactivation of the retinoblastoma susceptibility gene in human breast cancers
    • Lee, E.-Y, To, H., Shew, J.-Y., Bookstein, R., Scully, P. & Lee, W.-H. 1988 Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 241, 218-221.
    • (1988) Science , vol.241 , pp. 218-221
    • Lee, E.-Y.1    To, H.2    Shew, J.-Y.3    Bookstein, R.4    Scully, P.5    Lee, W.-H.6
  • 35
    • 0023845345 scopus 로고
    • H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system
    • Leon, J., Kamino, H., Steinberg, J. J. & Pellicer, A. 1988 H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system. Molec. Cell. Biol. 8, 786-793.
    • (1988) Molec. Cell. Biol. , vol.8 , pp. 786-793
    • Leon, J.1    Kamino, H.2    Steinberg, J.J.3    Pellicer, A.4
  • 37
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta, L. A., Steeg, P. S. & Stetler-Stevenson, W. G. 1991 Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64, 327-336.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 38
    • 0028051642 scopus 로고
    • Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes
    • Loughran, O., Edington, K. G., Berry, I. J., Clark, L. J. & Parkinson, E. K. 1994 Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes. Cancer Res. 54, 5045-5049.
    • (1994) Cancer Res. , vol.54 , pp. 5045-5049
    • Loughran, O.1    Edington, K.G.2    Berry, I.J.3    Clark, L.J.4    Parkinson, E.K.5
  • 39
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S. W, Schmitt, E. M., Smith, S. W, Osborne, B. A. & Jacks, T. 1993 p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 40
    • 0030460978 scopus 로고    scopus 로고
    • The p53 response to ionising radiation in adult and developing murine tissues
    • MacCallum, D. E. (and 10 others) 1996 The p53 response to ionising radiation in adult and developing murine tissues. Oncogene 13, 2575-2587.
    • (1996) Oncogene , vol.13 , pp. 2575-2587
    • MacCallum, D.E.1
  • 41
    • 0027138356 scopus 로고
    • The role of p21 ras in receptor tyrosine kinase signalling
    • Medema, R. H. & Bos, J. L. 1993 The role of p21 ras in receptor tyrosine kinase signalling. Crit. Rev. Oncogen. 4, 615-661.
    • (1993) Crit. Rev. Oncogen. , vol.4 , pp. 615-661
    • Medema, R.H.1    Bos, J.L.2
  • 42
    • 0029011539 scopus 로고
    • 5'CpG island methylation is associated with transcriptional silencing of the tumour suppressor CDKN2/p16 in human cancers
    • Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B. & Sidransky, D. 1995 5'CpG island methylation is associated with transcriptional silencing of the tumour suppressor CDKN2/p16 in human cancers. Nature Med. 7, 686-692.
    • (1995) Nature Med. , vol.7 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 43
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Balmain, A., Lane, D. P. & Hall, P. A. 1994 The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614-617.
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 45
    • 0029086835 scopus 로고
    • Distinct genetic loci control development of benign and malignant skin tumours in mice
    • Nagase, H., Bryson, S., Cordell, H., Kemp, C. J., Fee, F. & Balmain, A. 1995 Distinct genetic loci control development of benign and malignant skin tumours in mice. Nature Genet. 10, 424-429.
    • (1995) Nature Genet. , vol.10 , pp. 424-429
    • Nagase, H.1    Bryson, S.2    Cordell, H.3    Kemp, C.J.4    Fee, F.5    Balmain, A.6
  • 46
    • 0025932528 scopus 로고
    • A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogencsis
    • Navarro, P., Gomez, M., Pizarro, A., Gamallo, C., Quintanilla, M. & Cano, A. 1991 A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogencsis. J. Cell Biol. 115, 517-533.
    • (1991) J. Cell Biol. , vol.115 , pp. 517-533
    • Navarro, P.1    Gomez, M.2    Pizarro, A.3    Gamallo, C.4    Quintanilla, M.5    Cano, A.6
  • 49
    • 0029662049 scopus 로고    scopus 로고
    • TGFβ1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H. & Reichmann, E. 1996 TGFβ1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10, 2462-2477.
    • (1996) Genes Dev. , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 50
    • 0028785603 scopus 로고
    • Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
    • Parsons, R., MyerofT, L. L., Liu, B., Willson, J. K., Markowitz, S. D., Kinzler, K. W. & Vogelstein, B. 1995 Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res. 55, 5548-5550.
    • (1995) Cancer Res. , vol.55 , pp. 5548-5550
    • Parsons, R.1    Myeroft, L.L.2    Liu, B.3    Willson, J.K.4    Markowitz, S.D.5    Kinzler, K.W.6    Vogelstein, B.7
  • 52
    • 0025281090 scopus 로고
    • Inherited predisposition to cancer
    • Ponder, B. A. 1990 Inherited predisposition to cancer. Trends Genet. 6, 213-218.
    • (1990) Trends Genet. , vol.6 , pp. 213-218
    • Ponder, B.A.1
  • 53
    • 0027056098 scopus 로고
    • A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel
    • Potten, C. S., Li, Y. Q, O'Connor, P. J. & Winton, D. J. 1992 A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis 13, 2305-2312.
    • (1992) Carcinogenesis , vol.13 , pp. 2305-2312
    • Potten, C.S.1    Li, Y.Q.2    O'Connor, P.J.3    Winton, D.J.4
  • 54
    • 0030895235 scopus 로고    scopus 로고
    • Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium
    • Potten, C. S., Wilson, J. W. & Booth, G. 1997 Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells 15, 82-93.
    • (1997) Stem Cells , vol.15 , pp. 82-93
    • Potten, C.S.1    Wilson, J.W.2    Booth, G.3
  • 55
    • 0029587551 scopus 로고
    • Alternative reading frames of the INKA4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle, D. E., Zindy, F., Ashmun, R. A. & Sherr, C. J. 1995 Alternative reading frames of the INKA4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 56
    • 0022527161 scopus 로고
    • Carcinogen-specific mutation and amplification of Ha-ras during mouse skin Carcinogenesis
    • Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. 1986 Carcinogen-specific mutation and amplification of Ha-ras during mouse skin Carcinogenesis. Nature 322, 78-80.
    • (1986) Nature , vol.322 , pp. 78-80
    • Quintanilla, M.1    Brown, K.2    Ramsden, M.3    Balmain, A.4
  • 57
    • 0025986954 scopus 로고
    • Comparison of ras activation duringepidermal carcinogcnesis in vitro and in vivo
    • Quintanilla, M., Haddow, S., Jonas, D., Jaffe, D., Bowden, G. T. & Balmain, A. 1991 Comparison of ras activation duringepidermal carcinogcnesis in vitro and in vivo. Carcinogenesis 12, 1875-1881.
    • (1991) Carcinogenesis , vol.12 , pp. 1875-1881
    • Quintanilla, M.1    Haddow, S.2    Jonas, D.3    Jaffe, D.4    Bowden, G.T.5    Balmain, A.6
  • 58
    • 0028981085 scopus 로고
    • Loss of expression of the p16/ cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression
    • Reed, J. A. (and 10 others) 1995 Loss of expression of the p16/ cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res. 55, 2713-2718.
    • (1995) Cancer Res. , vol.55 , pp. 2713-2718
    • Reed, J.A.1
  • 59
    • 0029153609 scopus 로고
    • Kip/Cip and Ink-4 CDK inhibitors cooperate to induce cell cycle arrest in response to TGF-β
    • Reynisdottir, I., Polyak, K., lavarone, A. & Massague, J. 1995 Kip/Cip and Ink-4 CDK inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9, 1831-1845.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Lavarone, A.3    Massague, J.4
  • 60
    • 33646315166 scopus 로고
    • Cyclin D1 expression is a new marker of malignant progression in SENCAR mice
    • Robles, A. I., Stockman, S. L. & Conti, C. J. 1994 Cyclin D1 expression is a new marker of malignant progression in SENCAR mice. Proc. Am. Assoc. Cancer Res. 35,166.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 166
    • Robles, A.I.1    Stockman, S.L.2    Conti, C.J.3
  • 61
    • 0028104067 scopus 로고
    • Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H- Ras and cyl 1/cyclin D1 abnormalities
    • Ruggeri, B. A., Bauer, B., Zhang, S. Y. & Klein-Szanto, A. J. 1994 Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H- ras and cyl 1/cyclin D1 abnormalities. Carcinogenesis 15, 1613-1619.
    • (1994) Carcinogenesis , vol.15 , pp. 1613-1619
    • Ruggeri, B.A.1    Bauer, B.2    Zhang, S.Y.3    Klein-Szanto, A.J.4
  • 62
    • 0030034110 scopus 로고
    • Withdrawal of differentiation inhibitory activity/leukemia inhibitory activity factor upregulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells
    • Savatier, P., Lapillone, H., van Grunsven, L. A., Rudkin, B. B. & Samarut, J. 1995 Withdrawal of differentiation inhibitory activity/leukemia inhibitory activity factor upregulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 12, 309-322.
    • (1995) Oncogene , vol.12 , pp. 309-322
    • Savatier, P.1    Lapillone, H.2    Van Grunsven, L.A.3    Rudkin, B.B.4    Samarut, J.5
  • 64
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A. W, McCurrach, M. E., Beach, D. & Lowe, S. W. 1997 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 65
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr, C. J. & Roberts, J. M. 1995 Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
    • (1995) Genes Dev. , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 66
    • 0027200650 scopus 로고
    • The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event
    • Stoler, A. B., Stenback, F. & Balmain, A. 1993 The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J. Cell Biol. 122, 1103-1117.
    • (1993) J. Cell Biol. , vol.122 , pp. 1103-1117
    • Stoler, A.B.1    Stenback, F.2    Balmain, A.3
  • 67
    • 0025755955 scopus 로고
    • Hair follicular stem cells: The bulge-activation hypothesis
    • Sun, T. T., Cotsarelis, G. & Lavker, R. M. 1991 Hair follicular stem cells: the bulge-activation hypothesis. J. Invest. Dermatol. 96, 775-785.
    • (1991) J. Invest. Dermatol. , vol.96 , pp. 775-785
    • Sun, T.T.1    Cotsarelis, G.2    Lavker, R.M.3
  • 68
    • 0028129836 scopus 로고
    • Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
    • Van Meir, E. G., Polverini, P. J., Chazin,V. R., Su Huang, H. J., deTribolet, N. & Cavenee, W. K. 1994 Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genet. 8, 171-176.
    • (1994) Nature Genet. , vol.8 , pp. 171-176
    • Van Meir, E.G.1    Polverini, P.J.2    Chazin, V.R.3    Su Huang, H.J.4    DeTribolet, N.5    Cavenee, W.K.6
  • 69
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx, K.,Vakaer, L. Jr, Marcel, M., Fiers, W. & Van Roy, F. 1991 Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66, 107-119.
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaer Jr., L.2    Marcel, M.3    Fiers, W.4    Van Roy, F.5
  • 71
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. 1995 The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 72
    • 0028017632 scopus 로고
    • Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma
    • Yoo, G. H., Xu, H. J., Brennan, J. A., Westra, W, Hruban, R. H., Koch, W, Benedict, W. F. & Sidransky, D. 1994 Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res. 54, 4603-4606.
    • (1994) Cancer Res. , vol.54 , pp. 4603-4606
    • Yoo, G.H.1    Xu, H.J.2    Brennan, J.A.3    Westra, W.4    Hruban, R.H.5    Koch, W.6    Benedict, W.F.7    Sidransky, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.