Purified truncated recombinant HLA-B7 molecules abrogate cell function in alloreactive cytotoxic T lymphocytes by apoptosis induction

Transplantation

Volumn 66, Issue 12, 1998, Pages 1818-1822

  Hansen, Birgit ^a   Janssen, Edelgard ^a   Machleidt, Thomas ^a   Krönke, Martin ^a   Zavazava, Nicholas ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B7 ANTIGEN;

AFFINITY CHROMATOGRAPHY; APOPTOSIS; ARTICLE; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TARGET CELL DESTRUCTION;

ANIMALS; APOPTOSIS; HLA-B7 ANTIGEN; HUMANS; MICE; PROTEIN FOLDING; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032573726     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199812270-00041     Document Type: Article

References (25)

1. van Rood J, van Leeuwen A, van Santen M. Anti HL-A2 inhibitor in normal human serum. Nature 1970; 226: 366.
2. Emerson S, Murphy D, Cone R. Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. J Exp Med 1980; 152: 783.
3. Singh P, Brown R, Roser B. Class I transplantation antigens in solution in body fluids and in the urine. Individuality signals to the environment. J Exp Med 1988; 168: 195.
4. Clayberger C, Parham P, Rothbard J, Ludwig D, Schoolnik G, Krensky A. HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes. Nature 1987; 330: 763.
5. Parham P, Clayberger C, Zorn S, Ludwig D, Schoolnik G, Krensky A. Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the a2 domain of HLA-A2. Nature 1987; 325: 625.
6. Schneck J, Maloy W, Coligan J, Margulies D. Inhibition of an allospecific T cell hybridoma by soluble class I proteins and peptides: estimation of the affinity of a T cell receptor for MHC. Cell 1989; 56: 47.
7. Schneck J, Munitz T, Coligan J, Maloy W, Margulies D, Singer A. Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule. Proc Natl Acad Sci USA 1989; 86: 8516.
8. Elliott T, Eisen H. Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lymphocytes. Proc Natl Acad Sci USA 1988; 85: 2728.
9. Elliott T, Eisen H. Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc Natl Acad Sci USA 1990; 87: 5213.
10. Zavazava N, Hausmann R, Mueller-Ruchholtz W. Inhibition of anti-HLAB7 alloreactive CTL by affinity purified soluble HLA. Transplantation 1991; 51: 838.
11. Zavazava N, Krönke M. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat Med 1996; 2(9): 1005.
12. Rhode PR, Burkhardt M, Jiao J, Siddiqui AH, Huang GP, Wong HC. Single-chain MHC class II molecules induce T cell activation and apoptosis. J Immunol. 1996; 157: 4885.
13. Arimilli S, Mumm JB, Nag B. Antigen-specific apoptosis in immortalized T cells by soluble MHC class-II peptide complexes. Immunol Cell Biol 1996; 74(1): 96.
14. Stam N, Spits H, Ploegh H. Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol. 1986; 137: 2299.
15. Zavazava N, Westphal E, Mueller-Ruchholtz W. Characterization of soluble HLA molecules in sweat and quantitative HLA differences in serum of healthy individuals. J Immunogenet 1990; 17: 387.
16. Brodsky F, Parham P. Monomorphic anti-HLA-A,B,C monoclonal antibodies detecting molecular subunits and combinatorial determinants. J Immunol 1982; 128: 129.
17. Kroemer G, Petit P, Zamzami N, Vayssiere J, Mignotte B. The biochemistry of programmed cell death. FASEB J 1995; 9: 1277.
18. Podack E. Functional significance of two cytolytic pathways of cytotoxic T lymphocytes. J Leukoc Biol 1995; 57: 548.
19. Zavazava N. Soluble HLA class I molecules: biological significance and clinical implications. Mol Med Today 1998; 4: 161.
20. Abastado J, Lone Y, Casrouge A, Boulot G, Kourilsky P. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J Exp Med 1995; 182: 439.
21. Abastado J, Ojcius D, Casrouge A, et al. A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd. Eur J Immunol 1993; 23: 1776.
22. Hiraki D, See-Tho K, Filvaroff E, et al. Bioengineered soluble HLA-B7: genesis, characterization, and occurrence of dimerization. Human Immunol 1994; 40: 235.
23. Porto J, Johansen T, Catipovic B, et al. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc Natl Acad Sci USA 1993; 90: 6671.
24. Schneck JP, Sechler J, O'Herrin SM, Bieler JG, Barnes N, Rosenberg A. Specific inhibition of graft rejection by soluble MHC superdimers. Human Immunol 1996; 47: 149.
25. Nag B, Mukku PV, Astafieva I. Functionally active recombinant alpha and beta chain-peptide complexes of human major histocompatibility class II molecules. J Biol Chem 1996; 271(17): 10413.