Antiphospholipid antibodies bind to rat cerebellar granule cells: The role of N-methyl-D-aspartate receptors

Neuroscience Letters

Volumn 257, Issue 2, 1998, Pages 116-118

  Riccio, Antonella ^a   Andreassi, Catia ^a   Eboli, Maria Luisa ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Antiphospholipid antibodies; Excitotoxicity; Glutamate; N methyl D aspartate receptor; Rat cerebellar granules

Indexed keywords

DIZOCILPINE; EXCITATORY AMINO ACID; GLUTAMIC ACID; IMMUNOGLOBULIN G; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHOLIPID ANTIBODY;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CEREBELLUM; CONTROLLED STUDY; GRANULE CELL; IMMUNOFLUORESCENCE TEST; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SEIZURE;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; CEREBELLUM; COLORING AGENTS; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; IMMUNOGLOBULIN G; MITOCHONDRIA; NEURONS; NEUROTOXINS; OXIDATION-REDUCTION; OXIDOREDUCTASES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0032573437     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00793-9     Document Type: Article

References (15)

1. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
2. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insult with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA. 92:1995;7162-7166.
3. Brey R.L., Gharavi A.E., Lockshin M.D. Neurological complications of antiphospholipid antibodies. Rheumatol. Dis. Clin. North Am. 19:1993;833-850.
4. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
5. De Groot P.G., Oosting J.D., Derksen R.H.W.M. Antiphospholipid antibodies: specificity and pathophysiology. Baillieres Clin. Haematol. 6:1993;691-709.
6. Favaron M., Manev H., Alho H., Bertolino M., Ferret B., Guidotti A., Costa E. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc. Natl. Acad. Sci. USA. 85:1988;7351-7355.
7. Kent M., Vogt E., Rote N.S. Monoclonal antiphospholipid antibodies react directly with cat brain. Lupus. 3:1994;315.
8. Levi G., Aloisi F., Ciotti M.T., Gallo V. Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures. Brain Res. 290:1984;77-86.
9. Levine S.R., Brey R.L. Neurological aspects of antiphospholipid antibody syndrome. Lupus. 5:1996;347-353.
10. Liou H.H., Wang C.R., Chou H.C., Arvanov V.L., Chen R.C., Chan Y.C., Chuang C.Y., Chen C.Y., Tsai M.C. Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons. Life Sci. 54:1994;1119-1125.
11. 2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA. 87:1990;4120-4124.
12. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
13. Schultz D.R. Antiphospholipid antibodies: basic immunology and assays. Semin. Arthritis Rheumatol. 26:1997;724-739.
14. Vasquez-Mellado J., Llorente L., Richaud-Patin Y., Alarcon-Segovia D. Exposure of anionic phospholipids upon platelet activation permits binding of β2 glycoprotein I and through it that of IgG antiphospholipid antibodies. Studies in platelets from patients with antiphospholipid syndrome and normal subjects. J. Autoimmun. 7:1994;335-348.
15. Wong E.H.F., Kemp J.A., Priestly T., Knight A.R., Woodruff G.N. The anti-convulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Natl. Acad. Sci. USA. 83:1986;7104-7108.