Murine DNA (cytosine-5-)-methyltransferase: Steady-state and substrate trapping analyses of the kinetic mechanism

Biochemistry

Volumn 37, Issue 43, 1998, Pages 15162-15169

  Flynn, James ^a   Reich, Norbert ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA (CYTOSINE 5) METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ANIMAL CELL; ARTICLE; BASE PAIRING; COMPETITIVE INHIBITION; COMPLEX FORMATION; DNA METHYLATION; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; BINDING, COMPETITIVE; CATALYSIS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ISOTOPE LABELING; KINETICS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; POLYDEOXYRIBONUCLEOTIDES; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0032573129     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9810609     Document Type: Article

References (40)

1. Boyes, J., and Bird, A. P. (1991) Cell 64, 1123-1134.
2. Razin, A., and Riggs, A. D. (1980) Science 210, 604-609.
3. Kafri, T., Ariel, M., Brandeis, M., Shemer, R., Urven, L., McCarrey, J., Cedar, H., and Razin, A. (1992) Genes Dev. 6, 705-714.
4. Jost, J. P., and Saluz, H. P. (1993) DNA Methylation: Molecular Biology and Biological Significance, Birkhauser Verlag, Basel, Switzerland.
5. Li, E., Bestor, T. H., and Jaenisch, R. (1992) Cell 69, 915-926.
6. Szyf, M. (1996) Pharmacol. Ther. 70, 1-37.
7. Jones, P. A. (1996) Cancer Res. 56, 2463-2467.
8. Bestor, T., Laudano, A., Mattaliano, R., and Ingram, V. (1988) J. Mol. Biol. 203, 971-983.
9. Yen, R. C., Vertino, P. M., Nelkin, B. D., Yu, J. J., El-Deiry, W., Cumaraswamy, A., Lennon, G. G., Trask, B. J., Celano, P., and Baylin, S. B. (1992) Nucleic Acids Res. 20, 2287-2291.
10. Tajima, S., Tsuda, H., Wakabayashi, N., Asano, A., Mizuno, S., and Nishimori, K. (1995) J. Biochem. (Tokyo) 117, 1050-1057.
11. Kimura, H., Ishihara, G., and Tajima, S. (1996) J. Biochem. (Tokyo) 120, 1182-1189.
12. Aniello, F., Locascio, A., Fucci, L., Geraci, G., and Branno, M. (1996) Gene 178, 57-61.
13. Posfai, J., Bhagwat, A. S., Posfai, G., and Roberts, R. J. (1989) Nucleic Acids Res. 17, 2421-2435.
14. Leonhardt, H., Page, A. W., Weier, H., and Bestor, T. H. (1992) Cell 71, 865-873.
15. Bestor, T. H. (1992) EMBO J. 11, 2611-2617.
16. Chuang, L. S., Ng, H., Chia, J., and Li, B. F. L. (1996) J. Mol. Biol. 257, 935-948.
17. Glickman, J. F., Pavlovich, J. G., and Reich, N. O. (1997) J. Biol. Chem. 272, 17851-17857.
18. Ivanetich, K. M., and Santi, D. V. (1992) Prog. Nucleic Acid Res. Mol. Biol. 42, 127-156.
19. Wu, J. C., and Santi, D. V. (1987) J. Biol. Chem. 262, 4778-4786.
20. Klimasauskas, S., Kumar, S., Roberts, R. J., and Cheng, X. (1994) Cell 76, 357-369.
21. Osterman, D. G., DePhillis, G. D., Wu, J. C., Matsuda, A., and Santi, D. V. (1988) Biochemistry 27, 5204-5210.
22. Laird, P. W., Jackson-Grusby, L., Fazell, A., Dickinson, S. L., Jung, W. E., Li, E., Weinberg, R. A., and Jaenisch, R. (1995) Cell 81, 197-205.
23. Belinsky, S. A., Nikula, K. J., Baylin, S. B., and Issa, J. J. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 4045-4050.
24. Chuang, L. S., Ian, H. I., Koh, T. W., Ng, H. H., Xu, G., and Li, B. F. (1997) Science 277, 1996-2000.
25. Zhang, X. Y., and Verdine, G. L. (1996) FEBS Lett. 392, 179-183.
26. Lei, H., Oh, S. P., Okano, M., Juttermann, R., Goss, K. A., Jaenisch, R., and Li, E. (1996) Development 122, 3195-3205.
27. Pradhan, S., Talbot, D., Sha, M., Benner, J., Homstra, L., Li, E., Jaenisch, R., and Roberts, R. J. (1997) Nucleic Acids Res. 25, 4666-4673.
28. Xu, G., Flynn, J., Glickman, J. F., and Reich, N. O. (1995) Biochem. Biophys. Res. Commun. 207, 544-551.
29. Flynn, J., Glickman, J. F., and Reich, N. O. (1996) Biochemistry 35, 7308-7315.
30. Flynn, J., Azzam, R., and Reich, N. O. (1998) J. Mol. Biol. 279, 101-116.
31. Pedrali-Noy, G., and Weissbach, A., (1986) J. Biol. Chem. 261, 1, 7600-77602.
32. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 104-137.
33. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 173-187.
34. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
35. Surby, M., and Reich, N. O. (1996) Biochemistry 35, 2201-2008.
36. Surby, M., and Reich, N. O. (1996) Biochemistry 35, 2209-2217.
37. Alberty, R. A. (1958) J. Am. Chem. Soc. 80, 1777.
38. Rudolph, F. B. (1979) Methods Enzymol. 63, 411-436.
39. Rose, I. A. (1980) Methods Enzymol. 64, 47-59.
40. Reich, N. O., and Mashhoon, N. (1991) Biochemistry 30, 2933-2939.