The integrin β subunit

International Journal of Biochemistry and Cell Biology

Volumn 30, Issue 2, 1998, Pages 179-184

  Green, Linda J ^a   Mould, A Paul ^a   Humphries, Martin J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cytoplasmic domains; Ligand binding

Indexed keywords

INTEGRIN; PROTEIN SUBUNIT;

BETA CHAIN; CELL ADHESION; CELL CONTACT; CELL DIFFERENTIATION; CELL DIVISION; CELL MOTION; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMAN; INFECTION; INFLAMMATION; INJURY; LIGAND BINDING; NEOPLASM; NONHUMAN; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032571162     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(97)00107-6     Document Type: Article

References (16)

1. Tuckwell D., Humphries M.J. A structure prediction for the ligand-binding region of the integrin β subunit: Evidence for the presence of a von Willebrand factor A domain. FEBS Lett. 400:1997;297-303.
2. Bajt M.L., Loftus J.C. Mutation of a ligand binding domain of β3 integrin. J. Biol. Chem. 269:1994;20913-20919.
3. Bajt M.L., Goodman T., McGuire S.L. β2 (CD18) Mutations abolish ligand recognition by I domain integrins LFA-1 (αLβ2, CD11a/CD18) and MAC-1 (αMβ2, CD11b/CD18). J. Biol. Chem. 270:1995;94-98.
4. Michishita M., Videm V., Arnaout M.A. A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell. 72:1993;857-867.
5. Lee J.-O., Rieu P., Arnaout M.A., Liddington R. Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18). Cell. 80:1995;631-638.
6. Goodman T.G., Bajt M.L. Identifying the putative metal ion-dependent adhesion site in the β2 (CD18) subunit required for αLβ2 and αMβ2 ligand interactions. J. Biol. Chem. 271:1996;23729-23736.
7. Tozer E.C., Liddington R.C., Sutcliffe M.J., Smeeton A.H., Loftus J.C. Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit. J. Biol. Chem. 271:1996;21978-21984.
8. Puzon-McLaughlin W., Takada Y. Critical residues for ligand binding in an I domain-like structure of the integrin β1 subunit. J. Biol. Chem. 271:1996;20438-20443.
9. Diamond M.S., Springer T.A. The dynamic regulation of integrin adhesiveness. Curr. Biol. 4:1994;506-517.
10. Mould A.P. Getting integrins into shape: Recent insights into how integrin activity is regulated by conformational changes. J. Cell Sci. 109:1996;2613-2618.
11. Takada Y., Puzon W. Identification of a regulatory region of integrin β1 subunit using activating and inhibiting antibodies. J. Biol. Chem. 268:1993;17597-17601.
12. Mould A.P., Akiyama S.K., Humphries M.J. The inhibitory anti-β1 integrin monoclonal antibody 13 recognises an epitope that is attenuated by ligand occupancy: Evidence for allosteric inhibition of integrin function. J. Biol. Chem. 271:1996;20365-20374.
13. 2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 377:1995;75-79.
14. Dedhar S., Hannigan G.E. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr. Opinion Cell. Biol. 8:1996;657-669.
15. O'Toole T.E., Ylanne J., Culley B.M. Regulation of integrin affinity states through an NPXY motif in the β subunit cytoplasmic domain. J. Biol. Chem. 270:1995;8553-8558.
16. Hughes P.E., Diaz-Gonzalez F., Leong L., Wu C., McDonald J.A., Shattil S.J., Ginsberg M.H. Breaking the integrin hinge. J. Biol. Chem. 271:1996;6571-6574.