Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin

Tetrahedron Letters

Volumn 39, Issue 16, 1998, Pages 2247-2248

  Jayasuriya, Hiranthi ^a   Salituro, Gino M ^a   Smith, Scott K ^a   Heck, James V ^a   Gould, Steven J ^a   Singh, Sheo B ^a   Homnick, Carl F ^a   Holloway, M Katharine ^a   Pitzenberger, Steven M ^a   Patane, Michael A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CHLOROPEPTIN I; COMPLESTATIN; INTEGRASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG ISOLATION; HUMAN IMMUNODEFICIENCY VIRUS; STEREOCHEMISTRY; STREPTOMYCES; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION;

EID: 0032537210     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00270-6     Document Type: Article

References (9)

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2. (b) Kaneko, I.; Kamoshida, K.; Takahashi, S. J. Antibiot. 1989, 42, 236.
3. (c) Seto, H. Pure Appl. Chem. 1989, 61, 365.
4. (d) Seto, H.; Fujioka, T.; Furihata, K.; Kaneko, I.; Takahashi, S. Tetrahedron Lett. 1989, 30, 4987.
5. 2. (a) Matsuzaki, K.; Ogino, T.; Sunazuka, T.; Tanaka, H.; Omura, S. J. Antibiot. 1997, 50, 66.
6. (b) Matsuzaki, K.; Ikeda, H.; Ogino, T.; Matsumoto, A.; Woodruff, H. B.; Tanaka, H.; Omura , S. J. Antibiot. 1994, 47, 1173.
7. 3. Gouda, H.; Matsuzaki, K.; Tanaka, H.; Hirono, S.; Omura, S.; McCauley, J. A.; Sprengeler, P. A.; Furst, G. T.; Smith, A. B. III J. Am. Chem. Soc. 1996, 118, 13087.
8. 1H NMR spectrum of the reaction product showed the exclusive presence of chloropeptin I.
9. 5. Authentic samples of complestatin and chloropeptin I were unavailable to us.