Effects of tachykinin receptor antagonists on the rat jejunal distension pain response

European Journal of Pharmacology

Volumn 345, Issue 3, 1998, Pages 247-252

  McLean, Peter G ^a   Garcia Villar, Raphael ^a   Fioramonti, Jean ^a   Buéno, Lionel ^a  

^a CEMAGREF   (France)

Author keywords

Intestinal distension pain response; Tachykinin; Tachykinin receptor; Visceral nociception; Visceral sensation mechanism

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; OSANETANT; SAREDUTANT; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; INTESTINE DISTENSION; INTESTINE PRESSURE; JEJUNUM; MALE; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANALGESICS, NON-NARCOTIC; ANIMALS; BENZAMIDES; BLOOD PRESSURE; JEJUNUM; MALE; PAIN; PIPERIDINES; PRESSURE; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; RECEPTORS, TACHYKININ; REGRESSION ANALYSIS;

EID: 0032568303     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00040-5     Document Type: Article

References (32)

1. 2 receptor antagonist. Eur. J. Pharmacol. 250, 169-171.
2. Bentley, F.H., Smithwick, R.H., 1940. Visceral pain produced by balloon distension of the jejunum. Lancet i-ii, 389-391.
3. 1 receptors by use of the nonpeptide antagonist CP-96345. Br. J. Pharmacol. 104, 292-293.
4. Desai, M.C., Lefkowitz, S.L., Thadeio, P.F., Longo, K.P., Snider, R.M., 1992. Discovery of a potent substance P antagonist: recognition of the key molecular determinant. J. Med. Chem. 35, 4911-4913.
5. Diop, L., Riviere, P.J., Pascaud, X., Junien, J.L., 1994. Peripheral kappaopioid receptors mediate the antinociceptive effect of fedotozine on the duodenal pain reflex in rat. Eur. J. Pharmacol. 271, 65-71.
6. 2) receptor. Life Sci. 50, PL101-106.
7. 3 receptor. Life Sci. 56, PL27-32.
8. 2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs. Am. Rev. Respir. Dis. 148, 915-921.
9. Furness, J.B., Papka, R.E., Della, N.G., Costa, M., Eskay, R.L., 1982. Substance P-like immunoreactivity in nerves associated with the vascular system of guinea pigs. Neuroscience 7, 447-459.
10. Gamse, R., Holzer, P., Lembeck, F., 1980. Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin. Br. J. Pharmacol. 68, 207-213.
11. Gregersen, H., Kassab, G., 1996. Biomechanics of the gastrointestinal tract. Neurogastroenterol. Motil. 8, 277-297.
12. 3 receptors mediated antinociception and nociception respectively in response to rectal distension in rats. Neurogastroenterol. Mot. 7, 133-133.
13. Julia, V., Morteau, O., Bueno, L., 1994. Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats. Gastroenterology 107, 94-102.
14. Kellow, J.E., Eckersley, C.M., Jones, M.P., 1991. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 101, 1621-1627.
15. Lembeck, F., Skofitsch, G., 1982. Visceral pain reflex after pretreatment with capsaicin and morphine. Naunyn Schmied. Arch. Pharmacol. 321, 116-122.
16. Lipkin, M., Sleisenger, M.H., 1958. Studies of visceral pain: measurements of stimulus intensity and duration associated with the onset of pain in oesophagus, ileum and colon. J. Clin. Invest. 37, 28-34.
17. Mayer, E.A., Raybould, H.E., 1990. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 99, 1688-1704.
18. McLean, S., Ganong, A., Seymour, P.A., Snider, R.M., Desai, M.C., Rosen, T., Bryce, D.K., Longo, K.P., Reynolds, L.S., Robinson, G., 1993. Pharmacology of CP 99,994; a nonpeptide antagonist of the tachykinin neurokinin 1 receptor. J. Pharmacol. Exp. Ther. 267, 472-479.
19. 2 receptors. Eur. J. Pharmacol. 337, 279-282.
20. Moss, H.E., Sanger, G.J., 1990. The effects of granisetron. ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. Br. J. Pharmacol. 100, 497-501.
21. Ness, T.J., Gebhart, G.F., 1988. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudoaffective reflexes in the rat. Brain Res. 450, 153-169.
22. Ness, T.J., Gebhart, G.F., 1990. Visceral pain: a review of experimental studies. Pain 41, 167-234.
23. Patacchini, R., Bartho, L., Holzer, P., Maggi, C.A., 1995. Activity of SR 142801 at peripheral tachykinin receptors. Eur. J. Pharmacol. 278, 17-25.
24. Poncelet, M., Gucudet, C., Emonds-Alt, X., Breliere, J.C., Le Fur, G., Soubrie, P., 1993. Turning behavior induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a nonpeptide receptor antagonist. Neurosci. Lett. 149, 40-42.
25. Prochacci, P., Zoppi, M., Maresca, M., 1979. Experimental pain in man. Pain 6, 123-140.
26. 1 receptor antagonist CP 99,994 in guinea pigs. Eur. J. Pharmacol. 262, 171-175.
27. 2 receptor antagonist SR 48968 inhibits thalamic responses evoked by thermal but not mechanical nociception. Eur. J. Pharmacol. 237, 143-146.
28. Scott, C.M., Smith, G., Bountra, C., 1997. The differential effects of fentanyl on dorsal horn neurones responsive to colorectal distension within the lumbosacral cord of the anaesthetised rat. Br. J. Pharmacol. 120, 221P.
29. Seguin, L., Le Marouille-Girardon, S., Millan, M.J., 1995. Antinociceptive profiles of nonpeptidergic neurokinin 1 and neurokinin 2 receptor antagonists: a comparison to other classes of antinociceptive agent. Pain 61, 325-343.
30. Swarbrick, E.T., Bat, L., Hegarty, J.E., Williams, C.B., Dawson, A.M., 1980. Site of pain from the irritable bowel. Lancet ii, 443-446.
31. 1 receptor antagonist CP 99,994 attenuates cisplatin induced emesis in the ferret. Eur. J. Pharmacol. 250, R5-R6.
32. Tattersall, F.D., Rycroft, W., Hill, R.G., Hargreaves, R.J., 1994. Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin 1 receptor antagonist CP 99,994. Neuropharmacology 33, 259-260.