Role of transforming growth factor-β1 in the suppressed allostimulatory function of AIDS patients

AIDS

Volumn 12, Issue 5, 1998, Pages 481-487

  Brooks, Stephen P ^a   Bernstein, Zale P ^a   Schneider, Sara L ^c   Gollnick, Sandra O ^c   Tomasi, Thomas B ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c NONE

Author keywords

glycan; Accessory cell function; AIDS; Antigen presentation; Dendritic cells; HIV 1; Immunosuppression; T cells; Transforming growth factor 1

Indexed keywords

CYTOKINE ANTIBODY; DIDANOSINE; FLUORESCENT DYE; GLYCAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; ZALCITABINE; ZIDOVUDINE;

ACCESSORY CELL; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLOIMMUNITY; ANTIGEN PRESENTATION; ARTICLE; BLOOD LEVEL; CELL MEMBRANE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MIXED LYMPHOCYTE REACTION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTIBODIES; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; NEUTRALIZATION TESTS; PROTEOGLYCANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA; TRYPSIN;

EID: 0032568287     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199805000-00009     Document Type: Article

References (24)

1. Helbert MR, L'age-Stehr J, Mitchison MA: Antigen presentation, loss of immunological memory and AIDS. Immunol Today 1993, 14:340-344.
2. Knight SC: A problem of antigen presentation? Curr Biol 1994, 4:1131-1134.
3. Allen JB, Wong HL, Guyre PM, Simon GL, Wahl SM: Association of circulating receptor FcγRIII-positive monocytes in AIDS patients with elevated levels of transforming growth factor-β. J Clin Invest 1991, 87:1773-1779.
4. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M: Transforming growth factor β and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 1990, 87:8321-8325.
5. Cupp C, Taylor JP, Khalili K, Amini S: Evidence for stimulation of the transforming growth factor beta 1 promoter by HIV-1 Tat in cells derived from CNS. Oncogene 1993, 8:2231-2236.
6. Lotz M, Clark-Lewis I, Ganu V: HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes. J Cell Biol 1994, 124:365-371.
7. Zauli G, Vitale M, Gibellini D, Capitani S: Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor β1. J Exp Med 1996, 183:99-108.
8. Derynck R: TGF-β-receptor-mediated signaling. Trends Biochem Sci 1994, 19:548-553.
9. Massague J, Like B: Cellular receptor for type β transforming growth factor. J Biol Chem 1985, 260:2636-2645.
10. Lopez-Casillas F, Wrana JL, Massague J: Betaglycan presents ligand to the TGF-β signaling receptor. Cell 1993, 73:1435-1444.
11. Takahama Y, Letterio JJ, Suzuki H, Farr AC, Singer A: Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor β. J Exp Med 1994, 179:1495-1506.
12. Tomasi TB, Gollnick SO, Schneider SL, Brooks SP: A mechanism for inhibition of the MLR by TGF-β. FASEB J 1995 9 (suppl 4):A822.
13. O'Connor-McCourt MD, Wakefield LM: Latent transforming growth factor-β in serum. J Biol Chem 1987, 262:14090-14099.
14. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991, 9:271-296.
15. Macatonia SE, Lau R, Patterson S, Pinching AJ, Knight SC: Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 1990, 71:38-45.
16. Clerici M, Landay AL, Kessler HA, et al.: Multiple patterns of alloantigen presenting/stimulating cell dysfunction in patients with AIDS. J Immunol 1991, 146:2207-2213.
17. Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J: Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system. Cell 1991, 67:785-795.
18. Cheifetz S, Andres JL, Massague J: The transforming growth factor-β receptor type III is a membrane proteoglycan. J Biol Chem 1988, 263:16984-16991.
19. Blauvelt A, Clerici M, Lucey DR, et al.: Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. J Immunol 1994, 154:3506-3515.
20. Cameron PU, Forsum U, Teppler H, Granelli-Piperno A, Steinman RM: During HIV-1 infection most blood dendritic cells are not productively infected and can induce allogeneic CD4 + T cells clonal expansion. Clin Exp Immunol 1992, 88:226-236.
21. h and B cells. Lymphokine Cytokine Res 1991, 10:177-183.
22. Weissman DY, Li Y, Ananworanich J, et al.: Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infected with human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1995, 92:826-830.
23. Chopra RK, Raj NB, Scally JP, et al.: Lack of role of TGF-β1 in decreased lymphoproliferative response in HIV-1 infection. Clin Immunol Immunopathol 1993, 69:77-82.
24. Dustin M, Springer TA: T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989, 341:619-630.