Mode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen: A crystallographic and molecular modeling study

Journal of Biological Chemistry

Volumn 273, Issue 39, 1998, Pages 25413-25419

  Vasudevan, Sona ^a,c   Tsuruo, Takashi ^b   Rose, David R ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TOKYO   (Japan)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN P; MONOCLONAL ANTIBODY;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; GENE MAPPING; HUMAN; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; PROTEIN CONFORMATION;

EID: 0032566515     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.39.25413     Document Type: Article

References (59)

1. Juliano, R. L., and Ling, V. (1976) Biochim. Biophys. Acta 455, 152-162
2. Bradley, G., and Ling, V. (1994) Cancer Metastasis Rev. 13, 223-233
3. Shapiro, A. B., and Ling, V. (1995) J. Biol. Chem. 270, 16167-16175
4. Gerlach, J. H., Endicott, J. A., Juranka, P. F., Henderson, G., Sarangi, F., Deuchars, K. L., and Ling, V. (1986) Nature 324, 485-489
5. Chan, H. S., Grogan, T. M., DeBoer, G., Haddad, G., Gallie, B. L., and Ling, V. (1996) Eur. J. Cancer 6, 1051-1061
6. Chan, H. S., Haddad, G., Thorner, P. S., DeBoer, G., Lin, Y. P., Ondrusek, N., Yeger, H., and Ling, V. (1991) N. Engl. J. Med. 325, 1608-1614
7. Germann, U. A. (1996) Eur. J. Cancer 6, 927-944
8. Higgins, C. F. (1992) Annu. Rev. Cell Biol. 8, 67-113
9. Juranka, P. F. Zastawny, R. L., and Ling, V. (1989) FASEB J. 3, 2583-2592
10. Zhang, J. T. (1996) Mol. Biol. Cell 7, 1709-1721
11. Bosch, I., and Croop, J. (1996) Biochim. Biophys. Acta 1288, 37-54
12. Georges, E., Tsuruo, T., and Ling, V. (1993) J. Biol. Chem. 268, 1792-1798
13. Georges, E., Bradley, G., Gariepy, J., and Ling, V. (1989) Proc. Natl. Acad. Sci. U. S. A. 87, 152-156
14. Hamada, H., and Tsuruo, T. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 7785-7789
15. Watanabe, T., Naito, M., Kokubu, N., and Tsuruo, T. (1997) J. Natl. Cancer Inst. 89, 512-518
16. Tsuruo, T., Hamada, H., Sato, S., and Heike, Y. (1989) Jpn. J. Cancer Res. 80, 627-631
17. Vasudevan, S., Johns, K. L., and Rose, D. R. (1994) J. Mol. Biol. 241, 736-738
18. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119
19. Brunger, A. T., Krukowski, A., and Erickson, J. W. (1990) Acta Crystallogr. A 46, 585-593
20. Brunger, A. T. (1992) X-PLOR, Version 3.1, Yale University Press, New Haven
21. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. A 47, 392-400
22. Bernstein, F. C., Koetzle, T. F., Williams, G. J., Meyer, E. E., Jr., Brice, M. D., Rodgers, J. R., Kennard, O., Shimanouchi, T., and Tasumi, M. (1977) J. Mol. Biol. 112, 535-542
23. Satow, Y., Cohen, G. H., Padlan, E. A., and Davies, D. R. (1986) J. Mol. Biol. 190, 593-604
24. Brunger, A. T. (1992) Nature 355, 472-474
25. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Cryst. 26, 283-291
26. Connolly, M. L. (1983) J. Appl. Cryst. 16, 548-558
27. Li, H., and Poulos, T. L. (1995) Acta Crystallogr. D 51, 21-32
28. Evans, S. V. (1993) J. Mol. Graphics 11, 134-138
29. Ramachandran, G. N., and Sasisekharan, V. (1968) Adv. Protein Chem. 23, 283-438
30. Kabat, E. A., Wu, T. T., and Bilofsky, H. (1979) Sequences of Immunoglobulin Chains, NIH Publication 80-2008, National Institutes of Health
31. Chothia, C., and Lesk, A. M. (1987) J. Mol. Biol. 196, 901-917
32. Al-Lazikani, B., Lesk, A. M., and Chothia, C. (1997) J. Mol. Biol. 273, 927-948
33. Shirai, H., Kidera, A., and Nakamura, H. (1996) FEBS Lett. 399, 1-8
34. Morea, V., Tramontano, A., Rustici, M., Chothia, C., and Lesk, A. M. (1998) J. Mol. Biol. 275, 269-294
35. Herron, J. N., He, X. M., Ballard, D. W., Blier, P. R., Pace, P. E., Bothwell, A. L., Voss, E. W., Jr., and Edmundson, A. B. (1991) Proteins 11, 159-175
36. Rodier, F., and Janin, J. (1995) Proteins 23, 580-587
37. Vasudevan, S., and Rose, D. R. (1996) in Conformational Flexibility in Antibodies and Their Fragments in Protein Motions (Subbiah, S., ed) pp. 109-134., R. G. Landes Co., Austin, TX
38. Schneider, W. P., Wensel, T. G., Stryer, L., and Oi, V. T. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 2509-2513
39. Oh, B. H., Pandit, J., Kang, C. H., Nikaido, K., Gokcen, S., Ames, G. F., and Kim, S. H. (1993) J. Biol. Chem. 268, 11348-11355
40. Wilmot, C. M., and Thornton, J. M. (1990) Protein Eng. 3, 479-493
41. Wilmot, C. M., and Thornton, J. M. (1988) J. Mol Biol. 203, 221-232
42. Colman, P. M. (1988) Adv. Immunol. 43, 99-132
43. Davies, D. R., Padlan, E. A., and Sheriff, S. (1990) Annu. Rev. Biochem. 59, 439-473
44. Padlan, E. A. (1990) Proteins 7, 112-124
45. Rini, J. M., Schulze-Gahmen, U., and Wilson, I. A. (1992) Science 255, 959-965
46. Stanfield, R. L., Fieser, T. M., Lerner, R. A., and Wilson, I. A. (1990) Science 248, 712-719
47. Rini, J. M., Stanfield, R. L., Stura, E, A., Salinas, P. A., Profy, A. T., and Wilson, I. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6325-6329
48. Churchill, M. E., Stura, E. A., Pinilla, C., Appel, J. R., Houghten, R. A., Kono, D. H., Balderas, R. S., Fieser, G. G., Schulze-Gahmen, U., and Wilson, I. A. (1994) J. Mol. Biol. 241, 534-556
49. Ghiara, J. B., Stura, E. A., Stanfield, R. L., Profy, A. T., and Wilson, I. A. (1994) Science 264, 82-85
50. van den Elsen, J. M., Herron, J. N., Hoogerhout, P., Poolman, J. T., Boel, E., Logtenberg, T., Wilting, J., Crommelin, D. J., Kroon, J., and Gros, P. (1997) Proteins 29, 113-125
51. Shoham, M. (1993) J. Mol. Biol. 232, 1169-1175
52. Iwata, S., Ostermeier, C., Ludwig, B., and Michel, H. (1995) Nature 376, 660-669
53. Ostermeier, C., Iwata, S., Ludwig, B., and Michel, H. (1995) Nat. Struct. Biol. 2, 842-846
54. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296
55. Ravichandran, K. G., Boddupalli, S. S., Hasermann, C. A., Peterson, J. A., and Deisenhofer, J. (1993) Science 261, 731-736
56. Swain, A. L., Kretsinger, R. H., and Amma, E. L. (1989) J. Biol. Chem. 264, 16620-16628
57. Roquet, F., Declercq, J. P., Tinant, B., Rambaud, J., and Parello, J. (1992) J. Mol. Biol. 223, 705-720
58. Dewan, J. C., Mikami, B., Hirose, M., and Sacchettini, J. C. (1993) Biochemistry 32, 11963-11968
59. Stehle, T., Claiborne, A., and Schulz, G. E. (1993) Eur. J. Biochem. 211, 221-226