Identification of tryptophan hydroxylase as an intestinal autoantigen

Lancet

Volumn 352, Issue 9124, 1998, Pages 279-283

  Ekwall, Olov ^a   Hedstrand, Håkan ^a   Grimelius, Lars ^a   Haavik, Jan ^b   Perheentupa, Jaakko ^c   Gustafsson, Jan ^a   Husebye, Eystein ^b   Kämpe, Olle ^a   Rorsman, Fredrik ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DUODENUM MUCOSA; ENTEROCHROMAFFIN CELL; FINLAND; GENETIC TRANSCRIPTION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; MULTIPLE ENDOCRINE ADENOMATOSIS; NORWAY; PRIORITY JOURNAL; RNA TRANSLATION; SMALL INTESTINE; SWEDEN;

EID: 0032566209     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)11050-9     Document Type: Article

References (30)

1. 1 The Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997; 17: 399-403.
2. 2 Nagamine K, Peterson P, Scott HS, et al. Positional cloning of the APECED gene. Nat Genet 1997; 17: 393-98.
3. 3 Neufeld M, Maclaren N, Blizzard R. Autoimmune polyglandular syndromes. Pediatr Ann 1980; 9: 154-62.
4. 4 Ahonen P, Myllarniemi S, Sipila I, Perheentupa J. Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 1990; 322: 1829-36.
5. 5 Chen S, Sawicka J, Betterle C, et al. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. J Clin Endocrinol Metab 1996; 81: 1871-76.
6. 6 Peterson P, Uibo R, Peranen J, Krohn K. Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21. Clin Exp Immunol 1997; 107: 335-40.
7. 7 Winqvist O, Karlsson FA, Kämpe O. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 1992; 339: 1559-62.
8. 8 Rorsman F, Husebye ES, Winqvist O, Björk E, Karlsson FA, Kämpe O. Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc Natl Acad Sci USA 1995; 92: 8626-29.
9. 9 Tuomi T, Björses P, Falorni A, et al. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 1996; 81: 1488-94.
10. 10 Gebre-Medhin G, Husebye ES, Gustafsson J, et al. Cytochrome P450IA2 and aromatic L-amino acid decarboxylase are hepatic autoantigens in autoimmune polyendocrine syndrome type I. FEBS Lett 1997; 412: 439-45.
11. 11 Heubi JE, Partin JC, Schubert WK. Hypocalcemia and steatorrhea -clues to etiology. Dig Dis Sci 1983; 28: 124-28.
12. 12 Scire G, Magliocca FM, Cianfarani S, Scalamandre A, Petrozza V, Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency. J Pediatr Gastroenterol Nutr 1991; 13: 224-27.
13. 13 Bereket A, Lowenheim M, Blethen SL, Kane P, Wilson TA. Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. J Clin Endocrinol Metab 1995; 80: 933-35.
14. 14 Husebye ES, Gebre-Medhin G, Tuomi T, et al. Autoantibodies against aromatic L-amino acid decarboxylase in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 1997; 82: 147-50.
15. 15 Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L. Complex co-localization of chromogranins and neurohormones in the human gastrointestinal tract. J Histochem Cytochem 1997; 45: 815-22.
16. 5O release assessed by charcoal adsorption. J Neurosci Methods 1993; 48: 123-29.
17. 17 Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J. Complete coding sequence of human tryptophan hydroxylase. Nucleic Acids Res 1990; 18: 4257.
18. 18 Boadle-Biber MC. Regulation of serotonin synthesis. Prog Biophys Mol Biol 1993; 60: 1-15.
19. 19 Hufton SE, Jennings IG, Cotton RG. Structure and function of the aromatic amino acid hydroxylases. Biochem J 1995; 311: 353-66.
20. 20 Friedman PA, Lloyd T, Kaufman S. Production of antibodies to rat liver phenylalanine hydroxylase: cross-reactivity with other pterindependent hydroxylases. Mol Pharmacol 1972; 8: 501-10.
21. 21 Haan EA, Jennings IG, Cuello AC, et al. Identification of serotonergic neurons in human brain by a monoclonal antibody binding to all three aromatic amino acid hydroxylases. Brain Res 1987; 426: 19-27.
22. 22 Manns MP, Zanger U, Gerken G, et al. Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo. Hepatology 1990; 12: 127-32.
23. 23 Kobayashi T, Hasegawa H, Kaneko E, Ichiyama A. Gastrointestinal serotonin: depletion due to tetrahydrobiopterin deficiency induced by 2,4-diamino-6-hydroxypyrimidine administration. J Pharmacol Exp Ther 1991; 256: 773-79.
24. 24 Winqvist O, Gebre-Medhin G, Gustafsson J, et al. Identification of the main gonadal autoantigens in patients with adrenal insufficiency and associated ovarian failure. J Clin Endocrinol Metab 1995; 80: 1717-23.
25. 25 Mirakian R, Richardson A, Milla PJ, et al. Protracted diarrhoea of infancy: evidence in support of an autoimmune variant. BMJ 1986; 293: 1132-36.
26. 26 Corazza GR, Biagi F, Volta U, Andreani ML, De Franceschi L, Gasbarrini G. Autoimmune enteropathy and villous atrophy in adults. Lancet 1997; 350: 106-09.
27. 27 Lennon VA, Sas DF, Busk MF, et al. Enteric neuronal autoantibodies in pseudo-obstruction with small-cell lung carcinoma. Gastroenterology 1991; 100: 137-42.
28. 28 Yee C, Gilbert MJ, Riddell SR, et al. Isolation of tyrosinase-specific CD8+ and CD4+T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus. J Immunol 1996; 157: 4079-86.
29. 29 Song YH, Connor E, Li Y, Zorovich B, Balducci P, Maclaren N. The role of tyrosinase in autoimmune vitiligo. Lancet 1994; 344: 1049-52.
30. 30 Rahman MK, Nagatsu T, Kato T Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with L-DOPA and L-5-hydroxytryptophan as substrates. Biochem Pharmacol 1981; 30: 645-49.