Solid phase synthesis of substituted quinolin-2(1H)-one-3-carboxylic acids via an intramolecular knoevenagel condensation

Tetrahedron Letters

Volumn 39, Issue 52, 1998, Pages 9839-9840

  Watson, Brett T ^a   Christiansen, Gerda E ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Combinatorial chemistry; Knoevenagel condensation; Quinolinones; Solid phase synthesis

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; MALONIC ACID; QUINOLIN 2(1H) ONE 3 CARBOXYLIC ACID; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; MASS SPECTROMETRY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 0032564544     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02246-1     Document Type: Article

References (8)

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4. (b) MacDonald, A.A. Dewitt, S.H.; Hogan E.M.; Ramage, R. Tetrahedron Lett. 1996, 37, 4815-4818.
5. 4. Ruhland, T.; Küzner, H. Tetrahedron Lett. 1996, 37, 2757.
6. 5. Kulkarni, B.A.; Ganesan, A. Chem. Comm. 1998, 785.
7. 6. Hamper, B.C.; Kolodziej, S.A.; Scates, A.M. Tetrahedron Lett. 1998, 39, 2047-2050.
8. 2 (2x) and the filtrate was evaporated to give the product.