Positively charged residues at positions 12, 17, and 18 of glucagon ensure maximum biological potency

Journal of Biological Chemistry

Volumn 273, Issue 17, 1998, Pages 10308-10312

  Unson, Cecilia G ^a   Wu, Cui Rong ^a   Cheung, Connie P ^a   Merrifield, R B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ARGININE; ASPARTIC ACID; GLUCAGON; GLUCAGON DERIVATIVE; GLUCAGON RECEPTOR; HISTIDINE; LYSINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; ELECTRICITY; GLUCAGON RELEASE; HORMONE ACTION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HYDROPHOBICITY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ELECTROSTATICS; GLUCAGON; LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCAGON; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032562580     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.17.10308     Document Type: Article

References (39)

1. Jelinek, L. J., Lok, S., Rosenberg, G. B., Smith, R. A., Grant, F. J., Biggs, S., Bensch, P. A., Kuifper, J. L., Sheppard, P. O., Sprecher, C. A., O'Hara, P. J., Foster, D., Walker, K. M., Chen, L. H. J., Mckernan, P. A. & Kindsvogel, W. (1993) Science 259, 1614-1616
2. Segre, G. V. & Goldring, S. R. (1993) Trends Endocrinol. Metab. 4, 309-314
3. Thorens, B. M. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8641-8646
4. Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T. Takahashi, K. & Nagata, S. (1991) EMBO J. 10, 1635-1641
5. Usdin, T. B., Mesey, E., Button, D. C., Brownstein, M. J. & Bonner, T. J. (1993) Endocrinology 133, 2861-2870
6. Ishihara, T., Shigemoto, R., Mori, K. & Nagata, S. (1992) Neuron 8, 811-819
7. Unson, C. G., Macdonald, D., Ray, K., Durrah, T. L. & Merrifield, R. B. (1991) J. Biol. Chem. 266, 2763-2766
8. Unson, C. G., Wu, C.-R. & Merrifield, R. B. (1994) Biochemistry 33, 6884-6887
9. Lin, M. C., Wright, D. E., Hruby, V. J. & Rodbell, M. R. (1975) Biochemistry 14, 1559-1563
10. Hruby, V. J. (1982) Mol. Cell. Biochem. 44, 49-64
11. Hruby, V. J., Krstenansky, J. L., McKee, R. & Pelton, J. T. (1986) in Hormonal Control of Gluconeogenesis (Kraus-Friedman, N., ed) Vol. 2, pp. 3-20, CRC Press, Inc., Boca Raton, FL
12. Unson, C. G., Macdonald, D. & Merrifield, R. B. (1993) Arch. Biochem. Biophys. 300, 747-750
13. Unson, C. G. & Merrifield, R. B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 454-458
14. Unson, C. G., Cypess, A. M., Kim, H. N., Goldsmith, P. K., Carruthers, C. J. L., Merrifield, R. B. & Sakmar, T. P. (1995) J. Biol. Chem. 270, 27720-27727
15. Carruthers, C. J. L., Unson, C. G., Kim, H. N. & Sakmar, T. P. (1994) J. Biol. Chem. 269, 29321-29328
16. Carruthers, C. J. L. & Sakmar, T. P. (1995) Methods Neurosci. 25, 322-344
17. Buggy, J. J., Livingston, J. N., Rabin, D. U. & Yoo-Warren, H. (1995) J. Biol. Chem. 270, 7474-7478
18. Unson, C. G., Cypess, A. M., Wu, C.-R., Goldsmith, P., Merrifield, R. B. & Sakmar, T. P. (1996) Proc. Natl. Acad. Sci. U. S. A. 93 310-315
19. Krstenansky, J. L., Trivedi, D., Johnson, D. & Hruby, V. J. (1986) J. Am. Chem. Soc. 108, 1696-1698
20. Krstenansky, J. L., Zechel, C., Trivedi, D. & Hruby, V. J. (1988) Int. J. Pept. Protein Res. 32, 468-475
21. Trivedi, D., Ahn, J.-M., Lin, Y., Krstenansky, J. L., Burley, S. K., & Hruby, V. J. (1998) in Peptides: Chemistry, Structure, and Biology (Tam, J. P. & Kaumaya, P. T. P., eds) Kluwer Academic Publishers, Dordrecht, Netherlands, in press
22. Barany, G. & Merrifield, R. B. (1979) in The Peptides (Gross, E. & Meinhofer, J., eds) Vol. 2, pp. 1-284, Academic Press, New York
23. Merrifield, B. (1995) in Peptides: Synthesis, Structure, and Applications (Gutte, B., ed), pp. 93-169, Academic Press, New York
24. Unson, C. G., Andreu, D., Gurzenda, E. M. & Merrifield, R. B. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 4083-4087
25. Merrifield, R. B., Vizioli, L. D. & Boman, H. G. (1982) Biochemistry 21, 5020-5031
26. Pohl, S. L. (1976) in Methods in Receptor Research (Blecher M., ed) pp. 160-164, Marcel Dekker, Inc., New York
27. Wright, D. E. & Rodbell, M. (1979) J. Biol. Chem. 254, 268-269
28. Salomon, Y., Londos, C. & Rodbell, M. (1974) Anal. Biochem. 58, 541-548
29. Arunlakshana, O. & Schild, H. O. (1959) Br. J. Pharmacol. 14, 48-58
30. Carrey, E. A. & Epand, R. M. (1982) J. Biol. Chem. 257, 10624-10630
31. Van Tine, B. A., Azizeh, B. Y., Trivedi, D., Phelps, J. R., Houslay, M. D., Johnson, D. G. & Hruby, V. J. (1996) Endocrinology 137, 3316-3322
32. Unger, R. H. (1976) Diabetes 25, 136-151
33. Unger, R. H. & Orci, L. (1994) in Joslin's Diabetes Mellitus (Kahmad, R. R. & Weir, G. C., eds) 13th Ed., pp. 163-176, Lea and Febiger, Philadelphia
34. Cote, T. E. & Epand, R. M. (1979) Biochim. Biophys. Acta 582, 295-306
35. Bregman, M. D., Trivedi, D. & Hruby, V. J. (1980) J. Biol. Chem. 255, 11725-11731
36. Unson, C. G., Wu, C. R., Fitzpatrick, K. J. & Merrifield, R. B. (1994) J. Biol. Chem. 269, 12548-12551
37. Johnson, D. G., Goebel, C. U., Hruby, V. J., Bregman, M. D. & Trivedi, D. (1982) Science 215, 1115-1116
38. Unson, C. G., Gurzenda, E. M. & Merrifield, R. B. (1989) Peptides (Elmsford) 10, 1171-1177
39. Hjorth, S. A., Schambye, H. T., Greenlee, W. J. & Schwartz, T. W. (1994) J. Biol. Chem. 269, 30953-30959